Navigation Links
Drug-resistance fears for deadly fungal disease
Date:5/5/2011

Deadly human fungal infections caused by certain strains of Aspergillus fungi appear to be developing resistance to current drug treatments at an alarming rate, say scientists.

University of Manchester researchers, working with colleagues in Newark, USA, have developed a new test that can not only better diagnose Aspergillus infection, but can also spot signs of antifungal resistance to azoles the class of drugs used to treat patients with aspergillosis.

Using the new test, which uses direct molecular detection rather than culturing the fungus in a Petri dish, the team found that 55% of aspergillosis patients had telltale signs known as 'markers' that indicated they had developed resistance to azoles. The findings compare to resistance rates of 28% carried out by the team just two years ago using traditional culturing methods.

Furthermore, the study published in the prestigious US journal Clinical Infectious Diseases discovered azole-resistance markers in three-quarters of the small number of aspergillosis patients (eight) whom had never been treated with an azole, suggesting widespread dissemination of resistance.

"Aspergillus significantly worsens asthma symptoms and causes life-threatening infections in those with long-term lung infections or damaged immune systems, such as chemotherapy and transplant patients or people with HIV," said David Denning, Professor of Medicine and Medical Mycology at The University of Manchester and Director of the National Aspergillosis Centre at the University Hospital of South Manchester NHS Foundation Trust.

"Using an ultrasensitive, real-time test for Aspergillus, similar to the method used to diagnose HIV, MRSA and influenza, we have directly detected azole resistance in people with aspergillosis, without first culturing the fungus in a dish. The presence of Aspergillus was detected in many more samples than using traditional culture m
'/>"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fears of a decline in bee pollination confirmed
2. Disabled and other vulnerable groups more susceptible to terrorism fears
3. Researchers join forces to cure deadly childhood disease
4. Scientists track evolution and spread of deadly fungus, one of the worlds major killers
5. Sugar helping map new ground against deadly bug
6. Hunting for deadly bacteria
7. Personlized dendritic cell vaccine increases survival in patients with deadly brain cancer
8. Using artificial, cell-like honey pots to entrap deadly viruses
9. Chemical compounds in trees can fight deadly staph infections in humans
10. Vaccine made with synthetic gene protects against deadly pneumonia
11. Culling cant control deadly bat disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... Ebola is critical and pertinent for practicing physicians and ... and epidemic. The Journal, Disaster Medicine and Public ... Virus and Public Health, to surround the public, medical ... societal moment. , On October 17, the journal ... The primer was prepared by Dr. Eric Toner, internist ...
(Date:10/16/2014)... war on the human body. Battles are won, ... pancreatic cancer, this stalemate—known as tumor dormancy—can last ... a phenomena that is poorly understood. , ... of Salvatore Torquato, a Professor of Chemistry at ... tumor dormancy and the switch to a malignant ...
(Date:10/16/2014)... they are anything but sustainable: environmental damage to ... becoming increasingly evident. Despite their disadvantages, however, monocultures ... as the sole possibility of achieving higher yields ... Schmid, an ecology professor at the University of ... and forestry. After all, a new study carried ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
... method could enable scientists to generate snapshots of dozens of ... team from the Wyss Institute of Biologically Inspired Engineering at ... Such images could shed light on complex cellular pathways ... its prognosis, or monitor the effectiveness of therapies at a ...
... of East Anglia is launching a project to predict how ... sea ice chamber and using state-of-the-art computer models. The ... ocean, sea ice, snow and the atmosphere in polar regions. ... the European Research Council (ERC). Lead researcher Prof Roland ...
... neurodevelopmental disorders, different parts of the brain don,t talk ... for the first time, a way in which this ... published online today in Nature Neuroscience , scientists ... Italy, and collaborators at the Istituto Italiano di Tecnologia ...
Cached Biology News:Capturing ultrasharp images of multiple cell components at once 2Capturing ultrasharp images of multiple cell components at once 3€2M EU funding for UEA project to understand Arctic ice melt 2Making your brain social 2
(Date:10/18/2014)... The Asia-Pacific Liquid Crystal on Silicon (LCoS) display ... Asia-Pacific with analysis and forecast of revenue. This market ... expected to reach $380.0 million by 2018, at a ... through the TOC of the Asia-Pacific LCoS display market ... provided. This also provides a glimpse of the segmentation ...
(Date:10/18/2014)... (PRWEB) October 18, 2014 According to ... Resource & Well Type - Global Trends & Forecasts ... estimated $31 billion in 2011. This value is expected ... billion by 2017, with 10% CAGR during the same ... hydraulic fracturing production market in terms of hydraulic horse ...
(Date:10/17/2014)... a $451,781 Air Force Office of Scientific Research grant ... nano-scale level that will provide clues for predicting fatigue ... Aerospace Engineering, said the new technology and process would ... an aircraft,s wing., "We,ll be able to determine metal ... it on this scale," Huang said. "Certain patterns of ...
(Date:10/17/2014)... For the seventh consecutive year, ... in today’s print issue of Science magazine. , ... Survey polled employees in the biotechnology, pharmaceutical and ... Rankings were determined based on responses from ... companies on 23 characteristics, including financial strength, leadership ...
Breaking Biology Technology:The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 2Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 4UT Arlington project to detect possible damages in aircraft parts early in process 2DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3
... CITY, Dec. 4 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (NASDAQ: ... company focused on endocrine therapy and oncology, today announced ... take part in a panel discussion titled, "Replacing The ... RBC Capital Markets 2008 Healthcare Conference on Wednesday, December ...
... and secondhand smoke, an estimated ten percent of pregnant women ... baby to harmful cigarette byproducts from mothers who smoke affects ... health care burden. , Now, in the first study of ... assessment of newborns, umbilical cord blood to better understand the ...
... Dec. 3 CeloNova BioSciences, Inc., announced,today that ... is commercializing the,CATANIA(TM) Coronary Stent System with NanoThin ... any stent thrombosis in clinical studies. It is ... now some Middle,Eastern countries with aggressive world-wide expansion ...
Cached Biology Technology:Cutting the cord to determine babies' health risk from toxic exposure 2Cutting the cord to determine babies' health risk from toxic exposure 3Cutting the cord to determine babies' health risk from toxic exposure 4CeloNova BioSciences Commercializes CATANIA(TM) Coronary Stent With NanoThin Polyzene(R)-F in Europe and Middle East 2CeloNova BioSciences Commercializes CATANIA(TM) Coronary Stent With NanoThin Polyzene(R)-F in Europe and Middle East 3
... The EZ DNA Methylation Kit uses ... method for DNA methylation analysis. The kit ... that takes place between cytosine and sodium ... The EZ DNA Methylation Kits innovative in-column ...
... The DIGIVIEW line of digital x-ray ... radiation imaging device complete with 12 to ... area consists of a photodiode array sensor ... All models are available in low x-ray ...
... on rat tissue extracts (liver, kidney, spleen, and ... ) extract. It was also tested with microsomal ... Application: A simple and reliable method for measuring ... detection of the inorganic phosphate released from NDP ...
... BTX, the leader in electroporation products and ... innovative product line for experiment optimization and ... is a breakthrough in Molecular Delivery. The ... procedures that typically limited the number of ...
Biology Products: