Navigation Links
Drug resistance-associated genes: A cornerstone for the control and protection against tuberculosis
Date:9/5/2013

September 5, 2013, Shenzhen, China BGI in collaboration with Institute of Biophysics, Chinese Academy of Sciences, and other Chinese institutes, have completed the genome sequencing of 161 Mycobacterium tuberculosis that can cause an infectious disease tuberculosis (TB). The study published online in Nature Genetics provides an invaluable resource for researchers to better understand the genetic basis underlying drug resistance TB.

TB is one of the deadliest infectious diseases. The World Health Organization estimates that one-third of the world's population is infected with M. tuberculosis. Although TB control efforts have made an encouraging 1.3% decline in TB incidence worldwide each year since 2002, drug-resistant TB is still a serious and growing global challenge for treatment. The drug resistance is particularly acute in China, where 5.7% of new TB cases are multidrug-resistant (MDR), and 8% of MDR cases are extensively drug-resistant (XDR).

To understand the drug resistance mechanism from DNA level, Chinese researchers conducted a comprehensive genome-wide study of 161 M. tuberculosis strains with a broad range of resistance profiles (44 drug-sensitive, 94 MDR and 23 XDR isolates). In total, they discovered 72 novel genes, 28 intergenic regions (IGRs), 11 nonsynonymous SNPs and 10 IGR SNPs with strong, consistent associations with drug resistance.

Researchers found that the genetic basis of drug resistance is more complex than previously expected. The identification of new drug resistanceassociated genes, IGRs and SNPs provides a nearly complete gene set for studying drug resistance TB. These findings lay a solid foundation for the in-depth investigation of the drug resistance mechanisms in both M. tuberculosis and other bacterial pathogens treated with the same antibiotic regimens.

Dongfang Li, Project manager from BGI, said, "The drug resistance of M. tuberculosis is a very serious problem, especially in China. We expect our breakthrough can shed new insights for exploring the mechanisms of drug resistance, and lay a solid foundation for the control and protection against TB."


'/>"/>

Contact: Jia Liu
liujia@genomics.cn
BGI Shenzhen
Source:Eurekalert

Related biology news :

1. Its in the genes: Research pinpoints how plants know when to flower
2. An easier way to control genes
3. Cancer scientists discover novel way gene controls stem cell self-renewal
4. Unprecedented control of genome editing in flies promises insight into human development, disease
5. Target 2 forms of iron to control cystic fibrosis lung infection
6. Journal of Control, Automation and Electrical Systems now published by Springer
7. Natural pest control protein effective against hookworm: A billion could benefit
8. Controlling genes with light
9. Gallo Center scientists identify key brain circuits that control compulsive drinking in rats
10. Circadian rhythms control bodys response to intestinal infections, UCI-led study finds
11. Single-cell transfection tool enables added control for biological studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... 2016   Acuant , the leading ... has partnered with RightCrowd ® to ... Management, Self-Service Kiosks and Continuous Workforce Assurance. ... functional enhancements to existing physical access control ... with an automated ID verification and authentication ...
(Date:6/20/2016)... 20, 2016 Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring announced ... it has secured the final acceptance by all ... Managed Access Systems (MAS) installed. Furthermore, Securus will ... be installed by October, 2016. MAS distinguishes between ...
(Date:6/9/2016)... , June 9, 2016  Perkotek an innovation leader in attendance control systems is ... log work hours, for employers to make sure the right employees are actually signing ... http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case ... Denmark detail how a patient who developed lymphedema after being treated for breast cancer ... could change the paradigm for dealing with this debilitating, frequent side effect of cancer ...
(Date:6/23/2016)... Andrew D Zelenetz ... Published recently in Oncology ... touchONCOLOGY, Andrew D Zelenetz , discusses the ... is placing an increasing burden on healthcare systems ... With the patents on many biologics expiring, interest ...
(Date:6/23/2016)... Pleasant Prairie, WI (PRWEB) , ... June 23, ... ... sciences consultancy focused on quality, regulatory and technical consulting, provides a free ... webinar is presented on July 13, 2016 at 12pm CT at no charge. ...
(Date:6/23/2016)... June 23, 2016 ReportsnReports.com ... report to its pharmaceuticals section with historic and ... and much more. Complete report on ... pages, profiling 15 companies and supported with 261 ... http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . The Global Cell ...
Breaking Biology Technology: