Navigation Links
Drug resistance-associated genes: A cornerstone for the control and protection against tuberculosis
Date:9/5/2013

September 5, 2013, Shenzhen, China BGI in collaboration with Institute of Biophysics, Chinese Academy of Sciences, and other Chinese institutes, have completed the genome sequencing of 161 Mycobacterium tuberculosis that can cause an infectious disease tuberculosis (TB). The study published online in Nature Genetics provides an invaluable resource for researchers to better understand the genetic basis underlying drug resistance TB.

TB is one of the deadliest infectious diseases. The World Health Organization estimates that one-third of the world's population is infected with M. tuberculosis. Although TB control efforts have made an encouraging 1.3% decline in TB incidence worldwide each year since 2002, drug-resistant TB is still a serious and growing global challenge for treatment. The drug resistance is particularly acute in China, where 5.7% of new TB cases are multidrug-resistant (MDR), and 8% of MDR cases are extensively drug-resistant (XDR).

To understand the drug resistance mechanism from DNA level, Chinese researchers conducted a comprehensive genome-wide study of 161 M. tuberculosis strains with a broad range of resistance profiles (44 drug-sensitive, 94 MDR and 23 XDR isolates). In total, they discovered 72 novel genes, 28 intergenic regions (IGRs), 11 nonsynonymous SNPs and 10 IGR SNPs with strong, consistent associations with drug resistance.

Researchers found that the genetic basis of drug resistance is more complex than previously expected. The identification of new drug resistanceassociated genes, IGRs and SNPs provides a nearly complete gene set for studying drug resistance TB. These findings lay a solid foundation for the in-depth investigation of the drug resistance mechanisms in both M. tuberculosis and other bacterial pathogens treated with the same antibiotic regimens.

Dongfang Li, Project manager from BGI, said, "The drug resistance of M. tuberculosis is a very serious problem, especially
'/>"/>

Contact: Jia Liu
liujia@genomics.cn
BGI Shenzhen
Source:Eurekalert

Page: 1 2

Related biology news :

1. Its in the genes: Research pinpoints how plants know when to flower
2. An easier way to control genes
3. Cancer scientists discover novel way gene controls stem cell self-renewal
4. Unprecedented control of genome editing in flies promises insight into human development, disease
5. Target 2 forms of iron to control cystic fibrosis lung infection
6. Journal of Control, Automation and Electrical Systems now published by Springer
7. Natural pest control protein effective against hookworm: A billion could benefit
8. Controlling genes with light
9. Gallo Center scientists identify key brain circuits that control compulsive drinking in rats
10. Circadian rhythms control bodys response to intestinal infections, UCI-led study finds
11. Single-cell transfection tool enables added control for biological studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... -- That blood pressure plays a role in human health has ... term for high blood pressure – was first described as ... that,s used in measuring blood pressure was invented in 1896. ... hypertension, its triggers and its effects. In fact, recent findings ... best ways to treat it. For example, a ...
(Date:12/10/2014)... 2014 You,ve been here before: you desperately need ... your password, site key or the answer to your secret ... teacher? Today, Hoyos Labs , a ... will finally put an end to the frustration that comes ... . 1U leverages a user,s smartphone to acquire his or ...
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Wake Forest Baptist ... education building for its School of Medicine. Funding for ... larger capital campaign that will be publicly launched next ... be located in the former 60 series R.J. Reynolds ... Innovation Quarter. Construction will begin immediately with plans to ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... in Panama to use genetic barcoding, scientists at the ... 20 sand fly species from Barro Colorado Island. Two ... causes cutaneous leishmaniasis: persistent, itchy skin lesions. Three species ... that could contribute to a strategy to control the ...
... April 6, 2010 -- Spectacularly increased yields and improved ... researchers at the Robert H. Smith Faculty of Agriculture, ... Cold Spring Harbor Laboratory (CSHL), New York. The ... gene, which controls when plants make flowers and that ...
... scientists from around the world are involved in a ... research on the increasingly fragile relationship between humans and ... research as a priority and has selected MSU to ... on Coupled Human and Natural Systems, or CHANS-Net. The ...
Cached Biology News:Sand fly barcoding in Panama reveals Leishmania strain and its potential control 2Genetic key discovered to dramatically increase yields and improve taste of hybrid tomato plants 2Genetic key discovered to dramatically increase yields and improve taste of hybrid tomato plants 3MSU leads global effort to study link between people, planet 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... , Three-of-Four Patients Surveyed Experience Daily Pain From ... the European League Against Rheumatism Annual Congress of ... Results from the Rheumatoid Arthritis: Insights, Strategies ... rheumatoid arthritis (RA) patients throughout Europe and Canada ...
... SPRINGFIELD, Va., June 9 Methuselah Foundation has identified ... of bio-printing. The US Department of Health and ... be the standard of care for replacing all tissue/organ ... Methuselah Foundation, is applying its breakthrough organ printing technologies ...
... and Patient Reported Outcome Strategies , , PITTSBURGH, ... leader in electronic patient reported outcomes (ePRO) solutions and ... ePROficiency(TM) Web seminar series on Patient Reported Outcomes (PRO). ... a continuation of invivodata,s educational initiative which focuses on ...
Cached Biology Technology:New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 2New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 3New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 4New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 5New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 6Printing New Organs: Foundation Funds Medical Technology That Replicates Human Tissue 2invivodata Announces ePROficiency 2009 Web Seminar Series 2