Navigation Links
Drug resistance-associated genes: A cornerstone for the control and protection against tuberculosis
Date:9/5/2013

September 5, 2013, Shenzhen, China BGI in collaboration with Institute of Biophysics, Chinese Academy of Sciences, and other Chinese institutes, have completed the genome sequencing of 161 Mycobacterium tuberculosis that can cause an infectious disease tuberculosis (TB). The study published online in Nature Genetics provides an invaluable resource for researchers to better understand the genetic basis underlying drug resistance TB.

TB is one of the deadliest infectious diseases. The World Health Organization estimates that one-third of the world's population is infected with M. tuberculosis. Although TB control efforts have made an encouraging 1.3% decline in TB incidence worldwide each year since 2002, drug-resistant TB is still a serious and growing global challenge for treatment. The drug resistance is particularly acute in China, where 5.7% of new TB cases are multidrug-resistant (MDR), and 8% of MDR cases are extensively drug-resistant (XDR).

To understand the drug resistance mechanism from DNA level, Chinese researchers conducted a comprehensive genome-wide study of 161 M. tuberculosis strains with a broad range of resistance profiles (44 drug-sensitive, 94 MDR and 23 XDR isolates). In total, they discovered 72 novel genes, 28 intergenic regions (IGRs), 11 nonsynonymous SNPs and 10 IGR SNPs with strong, consistent associations with drug resistance.

Researchers found that the genetic basis of drug resistance is more complex than previously expected. The identification of new drug resistanceassociated genes, IGRs and SNPs provides a nearly complete gene set for studying drug resistance TB. These findings lay a solid foundation for the in-depth investigation of the drug resistance mechanisms in both M. tuberculosis and other bacterial pathogens treated with the same antibiotic regimens.

Dongfang Li, Project manager from BGI, said, "The drug resistance of M. tuberculosis is a very serious problem, especially
'/>"/>

Contact: Jia Liu
liujia@genomics.cn
BGI Shenzhen
Source:Eurekalert

Page: 1 2

Related biology news :

1. Its in the genes: Research pinpoints how plants know when to flower
2. An easier way to control genes
3. Cancer scientists discover novel way gene controls stem cell self-renewal
4. Unprecedented control of genome editing in flies promises insight into human development, disease
5. Target 2 forms of iron to control cystic fibrosis lung infection
6. Journal of Control, Automation and Electrical Systems now published by Springer
7. Natural pest control protein effective against hookworm: A billion could benefit
8. Controlling genes with light
9. Gallo Center scientists identify key brain circuits that control compulsive drinking in rats
10. Circadian rhythms control bodys response to intestinal infections, UCI-led study finds
11. Single-cell transfection tool enables added control for biological studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... In addition to the hippocampus, the marginal division ... and memory. What is the impact degree of ... learning and memory function? Yan Yu and his ... China found, using immunofluorescence staining, that substance P ... hippocampus and striatal marginal division of normal rats. ...
(Date:7/11/2014)... 11, 2014 Research and Markets ... Technology Market - Industry Analysis Size Share Growth Trends ... http://photos.prnewswire.com/prnh/20130307/600769 ... created a need for high level security in both ... authentication such as username and passwords, tokens etc. are ...
(Date:7/10/2014)... cities in New Mexico, nearly every public golf course ... precious potable water supplies. Across the U.S. Southwest as ... receive treated effluent. Reusing the effluent increases the sustainability ... homeowners alike fertilize their lawns during the growing season. ... Mexico State University turfgrass expert has a new vision ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2'Tailored' water -- the latest in lawn care 2
... June 2009 Elsevier, the leading publisher of scientific, ... the highlights of its journal impact factor performance in ... factors (IF) increase from 2007 to 2008. According to ... journals took the #1 position in 51 categories (of ...
... 2008 Olympic Games, world record times of the men,s 100m ... and technological advances. Imagine if this improvement could be achieved ... Research Institute of Wildlife Ecology in Austria have managed to ... high in polyunsaturated fatty acids. Polyunsaturated fatty acids are ...
... a changing climate depends on the nutritional value and yield ... Australia have found an increase in toxic compounds, a decrease ... under high CO 2 and drought conditions. ... 29 June 2009 at the Society for Experimental Biology Annual ...
Cached Biology News:Elsevier announces 2008 journal impact factor highlights 2Elsevier announces 2008 journal impact factor highlights 3Mice run faster on high-grade oil 2
(Date:7/10/2014)... Ind. , July 10, 2014 /PRNewswire/ ... its use of capnography for respiratory monitoring ... group of healthcare leaders in embracing state-of-the-art ... how effectively patients are breathing and can ... occurs. By measuring the amount of carbon ...
(Date:7/10/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/s3bqj2/photonic ... "International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, ... report to their offering. ... photonic integration traces its roots in the latter ... photonic integration went unexplored and unfulfilled for several ...
(Date:7/10/2014)... 2014 Using microscopic polymer light resonators that ... at MIT,s Quantum Photonics Laboratory have developed new ... parts-per-billion range. Optical sensors are ideal for detecting ... ratio, compact, lightweight nature, and immunity to electromagnetic ... been developed before, the MIT team conceived an ...
(Date:7/10/2014)... The lithium-ion batteries that power our laptops and ... on a single charge with the help of a ... material to replace the graphite traditionally used in one ... 10 times the energy storage capacity of graphite. A ... electrode was published today in Nature Communications . ...
Breaking Biology Technology:Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Swell new sensors 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... DIEGO, Sept. 2 NuVasive, Inc. (Nasdaq:,NUVA), a ... disruptive surgical treatments for the spine, announced today,that ... Kevin,O,Boyle, Executive Vice President and Chief Financial Officer, ... Healthcare Unplugged,Conference at the Grand Hyatt New York ...
... Sept. 2 Halozyme Therapeutics,Inc. (Nasdaq: ... products targeting the extracellular matrix, today,announced the ... Michael J. LaBarre, PhD, Vice President, Product ... "Halozyme is committed to attracting, developing, ...
... Mallinckrodt acknowledges validity of Purdue patents; Purdue licenses ... limited sales of some generic oxycodone strengths, STAMFORD, ... and Mallinckrodt Inc. of Hazelwood, Missouri have,agreed to end ... them in the United States District,Court for the Southern ...
Cached Biology Technology:NuVasive to Present at Morgan Stanley Global Healthcare Unplugged Conference 2NuVasive to Present at Morgan Stanley Global Healthcare Unplugged Conference 3Halozyme Therapeutics Strengthens Management Team, Appoints Additional Experienced Executives 2Halozyme Therapeutics Strengthens Management Team, Appoints Additional Experienced Executives 3Halozyme Therapeutics Strengthens Management Team, Appoints Additional Experienced Executives 4Purdue Pharma L.P. Announces Resolution of OxyContin(R) Patent Lawsuit with Mallinckrodt Inc. 2
The imaging screen-K (Kodak), tritium, is a 20 x 25 cm storage phosphor screen that is used for the quantitation and imaging of 32P, 33P, 35S, 14C, and 3H....
... Capillary Electrophoresis System uses revolutionary technology ... (SPE), urine protein electrophoresis and immunofixation/subtraction ... analysis. The system is truly automated, ... no staining to process patient samples. ...
The external laser upgrade for the Molecular Imager FX adds a 635 nm external laser; the 555 nm long pass filter is replaced with a 605 nm band pass filter to distinguish Cy5 from 532 nm excitable dy...
The filter 640DF35 for the Molecular Imager FX is a band pass filter for Texas Red dye....
Biology Products: