Navigation Links
Drug resistance-associated genes: A cornerstone for the control and protection against tuberculosis

September 5, 2013, Shenzhen, China BGI in collaboration with Institute of Biophysics, Chinese Academy of Sciences, and other Chinese institutes, have completed the genome sequencing of 161 Mycobacterium tuberculosis that can cause an infectious disease tuberculosis (TB). The study published online in Nature Genetics provides an invaluable resource for researchers to better understand the genetic basis underlying drug resistance TB.

TB is one of the deadliest infectious diseases. The World Health Organization estimates that one-third of the world's population is infected with M. tuberculosis. Although TB control efforts have made an encouraging 1.3% decline in TB incidence worldwide each year since 2002, drug-resistant TB is still a serious and growing global challenge for treatment. The drug resistance is particularly acute in China, where 5.7% of new TB cases are multidrug-resistant (MDR), and 8% of MDR cases are extensively drug-resistant (XDR).

To understand the drug resistance mechanism from DNA level, Chinese researchers conducted a comprehensive genome-wide study of 161 M. tuberculosis strains with a broad range of resistance profiles (44 drug-sensitive, 94 MDR and 23 XDR isolates). In total, they discovered 72 novel genes, 28 intergenic regions (IGRs), 11 nonsynonymous SNPs and 10 IGR SNPs with strong, consistent associations with drug resistance.

Researchers found that the genetic basis of drug resistance is more complex than previously expected. The identification of new drug resistanceassociated genes, IGRs and SNPs provides a nearly complete gene set for studying drug resistance TB. These findings lay a solid foundation for the in-depth investigation of the drug resistance mechanisms in both M. tuberculosis and other bacterial pathogens treated with the same antibiotic regimens.

Dongfang Li, Project manager from BGI, said, "The drug resistance of M. tuberculosis is a very serious problem, especially in China. We expect our breakthrough can shed new insights for exploring the mechanisms of drug resistance, and lay a solid foundation for the control and protection against TB."


Contact: Jia Liu
BGI Shenzhen

Related biology news :

1. Its in the genes: Research pinpoints how plants know when to flower
2. An easier way to control genes
3. Cancer scientists discover novel way gene controls stem cell self-renewal
4. Unprecedented control of genome editing in flies promises insight into human development, disease
5. Target 2 forms of iron to control cystic fibrosis lung infection
6. Journal of Control, Automation and Electrical Systems now published by Springer
7. Natural pest control protein effective against hookworm: A billion could benefit
8. Controlling genes with light
9. Gallo Center scientists identify key brain circuits that control compulsive drinking in rats
10. Circadian rhythms control bodys response to intestinal infections, UCI-led study finds
11. Single-cell transfection tool enables added control for biological studies
Post Your Comments:
(Date:9/29/2015)... excited to be named one of the first 100 IBM ... was recently made at an invite-only IBM Watson: Fueling ... , where iDAvatars presented a demo of its Intelligent ... is both an honor and a privilege to be one ... cognitive power of IBM Watson in our product, which empowers ...
(Date:9/28/2015)... -- According to a new market research ... & Others), Application (Access Control & Others), Industry (Travel ... Global - Forecast to 2020", published by MarketsandMarkets, the Iris ... by 2020, at a CAGR of 23.40% between 2015 ... T ables and 66 Figures spread ...
(Date:9/24/2015)... Publiceringsförbud fram till: ... Kerv ( ), det Londonbaserade ... första kontaktlösa betalningsring på i ett ... för massproduktion via crowdfunding.       ... Kerv-bärare kan göra direkta kontaktlösa betalningar ...
Breaking Biology News(10 mins):
(Date:10/13/2015)... ... October 13, 2015 , ... AxioMx ... that it has received a Phase I Small Business Innovative Research (SBIR) grant ... of General Medical Sciences (NIGMS), will fund the development of a technique to ...
(Date:10/13/2015)... , October 13, 2015 ... and development company, has entered into a strategic relationship ... and Paris, France ... --> --> This collaborative arrangement gives ... respected scientific advisory team as well as long established ...
(Date:10/13/2015)... YORK , Oct. 13, 2015  According ... laboratory services will reach $102 billion by the ... part of the health industry, as it is ... a result of laboratory tests. In addition to ... performed to evaluate disease progression, monitor drug treatment ...
(Date:10/13/2015)... ... October 13, 2015 , ... Exotic Automation ... handling solutions and components, is opening its latest Parker Store retail location in ... is Exotic’s second major expansion in Metropolitan Detroit in less than a year. ...
Breaking Biology Technology: