Navigation Links
Drug interactions won't exclude HCV transplant or HIV co-infected patients from treatment
Date:4/19/2012

treatment with PegIFN and RBV alone , new data shows TMC435 - an oral, once-daily, investigational HCV NS3/4A protease inhibitor - combined with PegIFN-alfa-2a and RBV achieves significantly higher SVR24 rates compared with placebo.(3) In the hardest to treat group of prior null-responders with cirrhosis, TMC435, PegIFN-alfa-2a and RBV treatment shows 61-80% SVR24 compared to 23% with placebo.

In other exciting data presented at the congress, the authors of a study on PSI-7977, a uridine nucleotide analog, propose that it may signal an end to response guided therapy in HCV GT1 patients.(4) Response-guided therapy is a paradigm for treating chronic HCV infections in which treatment decisions are based on how rapidly HCV responds to treatment.(5) With response-guided therapy, patients who rapidly clear virus from their bloodstream are eligible to receive a shorter duration of therapy, while slower responders receive standard or extended durations of therapy.(5)

In earlier studies, PSI-7977 has been associated with greater than 90% SVR (sustained virological response undetectable HCV RNA level 24 weeks after treatment) in HCV GT1, GT2, or GT3 patients, independent of predictors of poor responsiveness to interferon. In new data presented at the congress, the study authors show HCV GT1, GT4, or GT6 patients treated with PSI-7977 and PEG/RBV achieved 97% RVR (rapid virological response undetectable HCV RNA level after four weeks of treatment), with no viral breakthrough or relapse observed to date in subjects completing at least 10 weeks of PSI-7977.


'/>"/>

Contact: Travis Taylor
easlpressoffice@cohnwolfe.com
44-789-438-6428
European Association for the Study of the Liver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Aiding cancer therapy by mathematically modeling tumor-immune interactions
2. Neutron scattering provides window into surface interactions
3. Interactions between substances determine allergenic potential
4. Do plants perform best with family or strangers? Researchers consider social interactions
5. Molecule serves as a key in some protein interactions
6. University of Arizona to study human-fire-climate interactions
7. Researchers provide means of monitoring cellular interactions
8. Massive Daphnia genome leads to understanding gene-environment interactions
9. Scientists identify the largest network of protein interactions related to Alzheimers disease
10. Sharks and wolves: Predator, prey interactions similar on land and in oceans
11. Gene-environmental interactions and MS progression is focus of new study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Reportlinker.com announces that a new market ... Law Enforcement Biometrics Market in North America ... About Biometrics Biometrics is a technology that ... their physical or behavioral patterns. It involves the ... as fingerprints, face recognition, DNA, palm print, hand ...
(Date:8/27/2014)... requires nerve cells to rearrange existing patterns of activity ... patterns, a study of monkeys has found. The scientists ... electrical activity of brain cell networks. The study was ... "We looked into the brain and may have seen ... said Aaron Batista, Ph.D., an assistant professor at the ...
(Date:8/27/2014)... University of Utah biologist agan Sekercioglu, who campaigns to ... nation,s highest science prize, which is similar to the ... five researchers picked for 2014 the top awards by ... Three researchers won the Science Award and two ... equivalent to the Science Award but for scientists who ...
Breaking Biology News(10 mins):Law Enforcement Biometrics Market in North America 2014-2018 2Law Enforcement Biometrics Market in North America 2014-2018 3Law Enforcement Biometrics Market in North America 2014-2018 4Law Enforcement Biometrics Market in North America 2014-2018 5Scientists plug into a learning brain 2Scientists plug into a learning brain 3University of Utah biologist wins Turkey's top science prize 2
... Faculty Members Robert Ruff, Brian Olshansky and Luis Ruilope, ... blood clotting and major bleeding as effectively as warfarin, ... Dabigatran versus warfarin in patients with atrial fibrillation, by ... New England Journal of Medicine , says warfarin ...
... can learn a lot from an animal. By manipulating the ... a great deal about the genes and molecules behind many ... the same in people as they do in "model" animals. ... such as humans, ability to learn language from one another, ...
... with Stroud Water Research Center in Avondale, Pa., has ... Foundation to establish the Christina River Basin as a ... climate change. Scientists define the "critical zone" as ... the groundwater that sustains terrestrial life. The observatory ...
Cached Biology News:Transgenic songbirds provide new tool to understand the brain 2Critical Zone Observatory seeks to answer climate change questions 2Critical Zone Observatory seeks to answer climate change questions 3Critical Zone Observatory seeks to answer climate change questions 4
(Date:8/27/2014)...   MSC , a healthcare performance improvement company ... appointment of Mary Beth Loesch to President ... experience preparing companies for rapid growth and market expansion, ... of Corporate Development and Healthcare. In that role, she ... well as corporate strategy and marketing. Previously, Loesch served ...
(Date:8/27/2014)... Aug. 27, 2014 Research and ... "Global Lactic Acid  (Biodegradable Polymer, Food & Beverage, ... Forecasts to 2019" report to their offering. ... acid with an asymmetrical carbon atom. The main ... polymer, food and beverage, personal care product, and ...
(Date:8/27/2014)... -- Guggenheim Securities, the investment banking and capital markets ... veteran equity analyst Charles "Tony" Butler as a managing ... on the biotech/biopharma sector. " Tony Butler ... a broad network of relationships in his industry," said ... of Equities at Guggenheim Securities. "His insights will further ...
(Date:8/27/2014)... Research and Markets  has announced the addition of ... Report 2014" report to their offering. ... Report 2014 is a professional and in-depth study on ... spectrometer industry. The report provides a basic ... industry chain structure. The isotope ratio mass spectrometer market ...
Breaking Biology Technology:MSC names Mary Beth Loesch President and CEO 2Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2
... visualized data at the atomic scale. Source: Imago ... Australian facility for nanotechnology research, said it has commissioned ... Corp. , ,NANO officials said they were pleased ... use at the University of Sydney. , ,Imago makes ...
... Thailand and Sri Lanka when the chief disaster coordinator for ... stingy for not providing more relief. Many Americans shrugged off ... Others responded by doing what they would have done, anyway: ... predictable yes, predictable outpouring of private and corporate ...
... the ever-expanding realm of content management systems (CMS) providers, ... things simple for clients. Forget the gearhead techno-speak. The ... and business issues through plain talk and better Web ... use the Web, said Pat Bieser, founder and CEO ...
Cached Biology Technology:Are we stingy on tsunami relief? Not when private giving is counted 2Are we stingy on tsunami relief? Not when private giving is counted 3Untangling the Web: Northwoods Software in profile 2Untangling the Web: Northwoods Software in profile 3Untangling the Web: Northwoods Software in profile 4Untangling the Web: Northwoods Software in profile 5
... pulsed field separations of DNA larger than 2, ... megabase pairs. This agarose has the highest gel strength of any ... ... ...
Liquid. PBS containing 10 mM NaN 3 . AVOID FREEZE/THAW CYCLES. Recognizes α1, 2, 3, 5, 6 and 7 subunits of 20S proteasome. ...
Mouse monoclonal antibody to Lats2....
... Membrane Protein 2, Synaptobrevin 2). ... homology with any other known ... expected that the antibody will ... multata and bovine due to ...
Biology Products: