Navigation Links
Drug for erectile disorder show promise in the treatment of obesity
Date:4/1/2013

Although sildenafil is best known for promoting erections, it may also serve as a weight loss aid by coaxing our bodies to store more healthy "brown fat" relative to unhealthy "white fat" than it would otherwise do on its own. According to new research published online in The FASEB Journal, this is because sildenafil inhibits the breakdown of cyclic GMP, which has been well known as a messenger molecule used by the body to control blood pressure and flow, and has now been shown to play an important role determining which type of fatwhite or brownthe body stores.

"There is a growing need for novel treatments against obesity," said Alexander Pfeifer, M.D., Ph.D., a researcher involved in the work from the Institute of Pharmacology and Toxicology at the University of Bonn, Biomedical Center in Bonn, Germany. "Finding new positive effects of existing drugs, such as sildenafil, in adipose tissue might help to bridge the period until novel drugs against obesity have been developed."

To make this discovery, Pfeifer and colleagues used mice to show that cyclic GMP reduced the secretion of pro-inflammatory hormones, which, in turn, shifted the "color code" of fat from white to brown. Mice treated with sildenafil showed browning of the white fat after just a few days of treatment, which is believed to be the result of high cyclic GMP levels. Then the researchers used isolated fat cells and treated the cells directly with cyclic GMP and identified a "browning" effect as well.

"Clearly, size matters when it comes to our weight," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Numerous studies show that obesity is a risk factor for virtually every human disease, and that obesity is epidemic. The finding that Viagra and similar drugs can change our body fat composition has major implications. These drugs have well defined risk/benefit profiles and are approved for the treatment of erectile disorders. Further research will determine whether they are useful in the treatment of human girth disorders."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Dysfunction in cerebellar Calcium channel causes motor disorders and epilepsy
2. Researchers spot molecular control switch for preterm lung disorders
3. New gene variant may explain psychotic features in bipolar disorder
4. Adding to the list of disease-causing proteins in brain disorders
5. 2 new genes linked to amyotrophic lateral sclerosis and related disorders
6. Genetic risk factors for common eye disorder come into focus
7. MBL scientists find genes linked to human neurological disorders in sea lamprey genome
8. Unique peptide could treat cancers, neurological disorders, and infectious diseases
9. Grant to fund development of drug candidates for rheumatoid arthritis, neurodegenerative disorders
10. Circadian rhythms can be modified for potential treatment of disorders
11. Borderline personality disorder: The "perfect storm" of emotion dysregulation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... , Dec. 14, 2016 "Increase in ... biometrics market" The mobile biometrics market is expected to ... 49.33 billion by 2022, at a CAGR of 29.3% ... factors such as the growing demand for smart devices, ... transactions. "Software component is expected to grow ...
(Date:12/7/2016)... According to a new market research report "Emotion Detection and Recognition Market ... Application Area, End User, And Region - Global Forecast to 2021", published by ... 2016 to USD 36.07 Billion by 2021, at a Compound Annual Growth Rate ... ... MarketsandMarkets Logo ...
(Date:12/6/2016)... Dec. 6, 2016  Zimmer Biomet Holdings, Inc. (NYSE and ... an offering of €500.0 million principal amount of its 1.414% ... of its 2.425% senior unsecured notes due 2026. ... on December 13, 2016, subject to the satisfaction of customary closing ... The Company intends to use ...
Breaking Biology News(10 mins):
(Date:1/16/2017)... Jan. 16, 2017  Eurofins Genomics today announced the ... more customers to receive their primers in a shorter ... in quality found with other providers. Express oligos are ... at no additional fee. Researchers ... studies, including DNA sequencing, genotyping, site-directed mutagenesis, and cloning. ...
(Date:1/14/2017)... , Jan. 13, 2017  The Alliance for ... in response to FDA final guidance on ... its continued leadership in emphasizing the importance of distinct ... keenly aware of the benefits biosimilars will bring to ... Yet the portion of the Guidance dealing ...
(Date:1/13/2017)... , Jan 13, 2017 Research and Markets ... report to their offering. ... The global biopolymers market to grow at a CAGR of 16.83% during ... and the growth prospects of the global biopolymers market for 2017-2021. To ... sale of sales of biopolymer products. The report also includes a a ...
(Date:1/13/2017)... Island, NY (PRWEB) , ... January 13, 2017 ... ... to meet every cuvette-related demand that it has found among its diverse customer ... cuvettes for use in most brands electroporators including BTX and Bio-Rad. FireflySci ...
Breaking Biology Technology: