Navigation Links
Drug aimed at 2 bioterror agents blocks live viral infection, Weill Cornell team reports
Date:12/19/2007

ctious Diseases' Biodefense Research Agenda have included both viruses as potential bioterror agents.

"Theoretically, it's possible to go out into the field and collect Hendra virus from bats, for example," Dr. Moscona says. "We've been urgently working on this because right now there's absolutely nothing that can be done to stop this fatal, transmissible illness."

Luckily, prior research at Weill Cornell had laid out some important groundwork. The study's lead author, Dr. Matteo Porotto, has worked for years studying these types of microorganisms, using the parainfluenza virus as his model.

"We were able to develop the strategy that we describe in this paper because our work on parainfluenza had already helped us understand how these viruses fuse with host cells," says Dr. Porotto, assistant professor of microbiology in the Department of Pediatrics at Weill Cornell Medical College.

Based on that work, Drs. Porotto and Moscona knew that when the receptor-binding molecule on the virus -- simply called "G" -- binds to the surface of the cell, it activates a special "fusion protein." This fusion molecule has to then undergo some shape changes to turn itself into a six-helix bundle. Once that's done, it helps the virus fuse with, and enter, the cell, Dr. Porotto explains.

However, the Weill Cornell team discovered that a peptide specific to the parainfluenza virus "fusion protein" ("F") can inhibit this shape-changing step -- stopping fusion cold.

"Surprisingly, this parainfluenza F-peptide turned out to be even more effective at inhibiting Hendra virus fusion than peptides derived from the Hendra virus itself," Dr. Moscona says. "It also appears to do much the same thing with the Nipah virus, inhibiting fusion there, too."

The team discovered just why the F peptide works so well in a collaboration with Dr. Min Lu, associate professor of biochemistry at Weill Cornell. "These peptides act like door jambs --
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Using evolution, UW team creates a template for many new therapeutic agents
2. Primate behavior explained by computer agents
3. Building blocks of life
4. Natural product discovery by Cleveland medical researchers blocks tissue destruction
5. Scripps research team blocks bacterial communication system to prevent deadly staph infections
6. Building blocks of life formed on Mars
7. Clearance of hepatitis C viral infection after liver transplantation
8. Feline virus, antiviral drug studied to understand drug resistance
9. Cornell will host the Northeast Biofuel Summit, Nov. 11-13
10. First symposium of UN University-Cornell Africa Series to be held at UN
11. Wiggle room: Cornell researcher borrows idea from sperm to provide energy for nanoscale robots
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... could one day be made out of cocoa, rice ... reporting. The novel process they developed and their results, ... and plastic waste problems, appear in the ACS journal ... and colleagues at the Italian Institute of Technology point ... its production reached 288 million tons worldwide, but its ...
(Date:8/20/2014)... When a colony of honeybees grows to about 4,000 ... reproductive cycle: the building of a special type of ... team of experts from the Department of Neurobiology and ... what starts the reproductive cycle of honeybee colonies. The ... The Science of Nature . , Reproduction isn,t ...
(Date:8/20/2014)... and POINT ROBERTS, Washington , August 20, ... Key Role in Addressing Security Concerns in the Payment Industry? ... news source covering leading sectors including biometrics, issues commentary from ... Jason Peaslee , Managing Partner at Thrive Analytics, ... Gino Pereira , CEO of NXT-ID, Inc. (OTCBB: NXTD) ( ...
Breaking Biology News(10 mins):Worker bees 'know' when to invest in their reproductive future 2Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 2Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 3Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 4Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 5Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 6Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 7
... An in-depth study by Sandia National Laboratories and ... waste and dedicated energy crops could sustainably replace nearly ... The goal of the "90-Billion Gallon Biofuel ... large volume of cellulosic biofuel could be sustainably produced, ...
... that road salt used throughout the winter is making ... aquatic life and drinking water. The research indicates ... judicious use of road salt could help lessen the ... a video with research team leader Heinz Stefan, go ...
... elevations in Arizona,s Santa Catalina Mountains as summer temperatures ... Arizona in Tucson. The flowering ranges of 93 ... to where the same species flowered the previous ten ... the region increased about 1.8 degree Fahrenheit (1 degree ...
Cached Biology News:Biofuels can provide viable, sustainable solution to reducing petroleum dependence 2Biofuels can provide viable, sustainable solution to reducing petroleum dependence 3U of Minnesota research finds most road salt is making it into the state's lakes and rivers 2Plants take a hike as temperatures rise 2Plants take a hike as temperatures rise 3
(Date:8/20/2014)... August 20, 2014 The 6th ... being held on October 29-30 in San Francisco, CA. ... academic and government researchers and clinicians focused on addressing ... , In the twelve years since the sequencing ... have been introduced with pharmacogenetic information in the label ...
(Date:8/20/2014)... WriteResult®, a leading provider of Electronic Patient Outcome ... myPROpad™ ePRO tablet with the addition of a touchscreen ... widely used and well-respected Patient Reported Outcome (PRO) instruments ... used during clinical trials and in other health care ... to demonstrate Health-Related Quality of Life outcomes (HRQoL) resulting ...
(Date:8/19/2014)... Research and Markets  has announced the addition of the "Cell ... to their offering. This report analyzes the worldwide ... the following Product Segments: Media, Sera, and Reagents. The ... , Japan , Europe ... . Annual estimates and forecasts are provided for the period ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 Robin Williams’ ... disease can take on an individual. Symptoms range ... facial expression, problems swallowing and severe depression. Parkinson’s ... dying off of dopamine producing neurons of the brain. ... a disease that slowly and progressively gets worse, they ...
Breaking Biology Technology:6th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2EQ-5D™ Assessment Now Available for iPad 2Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3
... Silence Therapeutics plc (AIM: SLN) ("Silence", the "Group" or ... company, today announces the appointment of Thomas Christély as ... based at Silence,s facility in Berlin. Thomas ... in corporate and business development and finance. He was ...
... researchers have developed a new technique to reach neurons ... and noninvasively. Up until now, scientists have thought that ... required. But in this new study, the Columbia Engineering ... can open the blood-brain barrierwith the added advantages of ...
... Korea, August 8, 2011Can a flexible LED conformably placed on ... human brain, or rolled upon the blood vessels, diagnose or ... in the near future. The team of Professor Keon ... developed a new concept: a biocompatible, flexible Gallium Nitride (GaN) ...
Cached Biology Technology:Appointment of Chief Executive Officer 2Appointment of Chief Executive Officer 3Appointment of Chief Executive Officer 4Engineers use short ultrasound pulses to reach neurons through blood-brain barrier 2
Mouse monoclonal [M7-PB-E9] to pan alpha Sodium Potassium ATPase ( Abpromise for all tested applications)....
Transcription factor Sp2. [Source:Uniprot/SWISSPROT;Acc:Q02086] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
... [EP282Y] to Asparagine synthetase ( ... applications). Antigen: ... residues in the C-terminus of ... Entrez GeneID: 440 ...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
Biology Products: