Navigation Links
Drop in temperature may explain the increase in dry eye suffering
Date:3/3/2011

Springtime may be just what the doctor orders for individuals suffering from dry eye condition, a disorder resulting from insufficient tear production or altered tear film composition. According to a study published in Investigative Ophthalmology & Visual Science, a temperature less than 30 degrees Celsius on the eye and eyelid could be the cause for the onset or worsening of the disorder.

The study, (Meibomian Lipid Films and the Impact of Temperature) showed that the cold temperature causes the meibum, the oily substance which helps to form the outermost layer of the tear film, to become too thick and stiff to spread onto the eye surface.

"In outdoor conditions, the wind accelerates the drop in temperature of the ocular surface and the eyelids, thus the effect is even more pronounced," says author Igor A. Butovich, PhD, assistant professor, Department of Ophthalmology and Graduate School of Biomedical Sciences at the University of Texas Southwestern Medical Center. "This mechanism seems to be one of the major factors that cause dry eye to worsen in cold, windy weather such that it can affect even healthy people."

Based on previous experience, the research team expected to see measurable effects of temperature on meibum. However, the researchers were surprised the results of their experiment found that a bulk of meibum abruptly melted in a very narrow range of temperatures, right around an eye surface and eyelid temperature of 32 34 degrees Celsius. If the temperature fell just a few degrees below that, the bulk meibum solidified, which could then result in plugging up the meibomian gland ducts.

The experiments further demonstrated that even if the thicker, stiffer substance does reach the eye surface, it may not spread as easily as under normal conditions. The tear film that forms on the eye will not have the right characteristics, which might cause it to evaporate more quickly and decrease its protective capabilities.

Butovich underscores that the goal is to maintain the quality of the tear film as close to normal as possible, under all conditions. "In cold climate, anything that keeps eyes and eyelids warm should help meibum flow easier, and form and maintain a better tear film; in windy conditions, protection from the wind for example, with eye goggles should reduce the tear film evaporation."

The authors strongly suggest that temperature be tightly controlled in future studies, especially since over-the-counter and prescription eye lubricant formulations that are being tested are most likely temperature-dependent. "Our experiments provided strong evidence that even a small drop in the ocular surface and eyelid temperatures is critical," stresses Butovich. "It would be logical to use this information and our approaches while designing new eye drop formulations."


'/>"/>

Contact: Katrina Norfleet
knorfleet@arvo.org
240-221-2924
Association for Research in Vision and Ophthalmology
Source:Eurekalert

Related biology news :

1. The water temperature in the subtropical Atlantic falls due to wind action
2. Winter temperatures play complex role in triggering spring budburst
3. 98.6 degrees Fahrenheit ideal temperature for keeping fungi away and food at bay
4. Drought and rising temperatures weaken southwest forests
5. Decline of West Coast fog brought higher coastal temperatures last 60 years
6. Can cacti escape underground in high temperatures?
7. As Arctic temperatures rise, tundra fires increase, researchers find
8. Change in temperature uncovers genetic cross talk in plant immunity
9. King crab distributions limited by temperature in the Southern Ocean
10. Carbon dioxide controls Earths temperature
11. Smithsonian reports regional sea temperature rise and coral bleaching event in Western Caribbean
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access System ... over the next decade to reach approximately $1,580 million by 2025. ... forecasts for all the given segments on global as well as ...
(Date:3/22/2017)... NEW YORK , March 21, 2017 /PRNewswire/ ... Customer Marketing Cloud used by retailers such as ... in its platform — Product Recommendations and Replenishment. Using ... to give more personalized product and replenishment recommendations ... purchases, but also on predictions of customer intent ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... As part ... the series will explore the laboratory testing for DIC in order to illuminate this ... disorder which can occur in hospitalized patients resulting in a high degree of morbidity ...
(Date:4/25/2017)... ... 25, 2017 , ... Covalent Metrology has two ... unit provides high-quality data to clients, both faster and cheaper than competing ... are no price premiums, and customers are welcome to participate in the measurements ...
(Date:4/21/2017)... ... April 21, 2017 , ... Having worked on the design ... is pleased to introduce it to top lab design architects from around the country ... and VP of Industrial Design and Engineering Greg Casey will be at the show, ...
(Date:4/21/2017)... ... April 21, 2017 , ... Frederick ... a range of emerging technology-based businesses, recently earned a $77,518 grant from the ... , Founded in 2004, FITCI is Frederick’s first incubator. A non-profit corporation, FITCI ...
Breaking Biology Technology: