Rome, Italy: Mothers who drink alcohol while they are pregnant may be damaging the fertility of their future sons, according to new research to be presented at the 26th annual meeting of the European Society of Human Reproduction and Embryology in Rome today (Tuesday 29 June).
Doctors in Denmark found that if mothers had drunk 4.5 or more drinks a week while pregnant, then the sperm concentration of their sons, measured about 20 years later, was a third lower in comparison to men who were not exposed to alcohol while in the womb. A drink was measured as 12 grams of alcohol, which is the equivalent to one 330 ml beer, one small (120 ml) glass of wine or one glass of spirits (40 ml).
Dr Cecilia Ramlau-Hansen, senior researcher at the Department of Occupational Medicine, Aarhus University Hospital (Denmark) and clinical associate professor at the Department of Epidemiology, Institute of Public Health, University of Aarhus, told a news briefing: "Our study shows that there is an association between drinking a moderate amount of alcohol (about four to five drinks a week) during pregnancy and lower sperm concentrations in sons. However, because this is an observational study we cannot say for certain that the alcohol causes the lower sperm concentrations. It is possible that drinking alcohol during pregnancy has a harmful effect on the foetal semen-producing tissue in the testes and thereby on semen quality in later life but our study is the first of its kind, and more research within this area is needed before any causal link can be established or safe drinking limits proposed."
Dr Ramlau-Hansen and her colleagues studied 347 sons of 11,980 women with singleton pregnancies who were recruited to the Danish "Healthy habits for two" study between 1984-1987. Around the 36th week of pregnancy the mothers answered a questionnaire on lifestyles and health. The sons were followed up between 2005-2006, when they were aged between 18-21, and semen
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European Society of Human Reproduction and Embryology