Since the dawn of civilization people were searching for clues to longevity and trying to extend human lifespan. But only in the past two decades with the advances in genetic sequencing, epigenetic analysis, and increased government investments the area experienced rapid expansion in the knowledge base, allowing scientists to develop comprehensive models and theories of aging. And while there is still much disagreement among scientists, the evolutionary theories are dominating the field. These theories predicted existence of certain genes that provide selective advantage early in life with adverse effects on lifespan later in life or longevity insurance genes. Indeed, the study of human and animal genetics is gradually identifying new genes that increase lifespan when overexpressed or mutatedgerontogenes. Furthermore, genetic and epigenetic mechanisms are being identified that have positive effects on longevity.
"The study of the effects of mutations and epimutations on life expectancy and the aging rate expands the range of potential pharmacological and genoteraputic targets, as well as biomarkers of treatment of aging-dependent pathologies," said professor Alexey Moskalev, PhD, DSc, head of the laboratories for aging research at the Institute of Biology of the Russian Academy of Sciences and at the Moscow Institute of Physics and Technology.
The international group of scientists performed a comprehensive analysis of the genetic and epigenetic mechanisms and demonstrated that the majority of the genes, as well as genetic and epigenetic mechanisms that are involved in regulation of longevity, are highly interconnected and related to stress response. Also, for the first time, the group performed a comprehensive analysis of government research grants related to the genes involved in aging. One of the tools that may help understand the direction of scientific research that is still unpublished are research grant abstracts. To better understand
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