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Double trouble: Bacterial super-infection after the flu
Date:1/22/2010

nd immunocompetent mice suggests that even normal healthy people are at increased risk for complications following bacterial super-infection.

Lee et al suggest that the "lethal synergy between influenza virus and the bacterial respiratory pathogen, H. influenzae, is mediated by innate immunity. They observed that severe damage to the airways was an early event in the co-infected mice, eventually leading to death. This underscores the need for early antiviral and antibiotic treatment to combat severe disease in human patients and highlights the importance of vaccination and effective hygiene measures to prevent secondary bacterial infections during influenza infection. This new model will be useful for further investigating the mechanisms underlying severe disease caused by the interaction between influenza virus and bacteria, which may have resulted in numerous deaths during influenza pandemics and continues to constitute a significant clinical problem in susceptible individuals." Currently ongoing studies suggest that this model may also be useful for identifying target molecules for the development of novel therapeutic agents and strategies.


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Contact: Angela Colmone, Ph.D.
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1 2

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