Navigation Links
Double the pain: RUB biologists find the cause of pain in the treatment of fair skin cancer
Date:6/20/2012

Apply the ointment, light on, light off that's how easy it is to cure various forms of non-melanoma skin cancer. However, the majority of patients suffer severe pain during the so-termed photodynamic therapy. Why the treatment with ointment and red light can be so painful has now been uncovered by researchers from the RUB. They identified the ion channels involved and signalling molecules secreted by the cancer cells. "The results may provide a starting point for suppressing the pain", says Dr. Ben Novak of the Department of Animal Physiology.

How the photodynamic therapy works

In contrast to normal cells, cancer cells are equipped with different enzymes and have a much higher metabolism. If you apply a molecule called aminolevulinic acid to the skin in the form of a gel, cancer cells take up considerably more of this substance than healthy cells. If aminolevulinic acid accumulates in the cells, the mitochondria the power plants of the cells form the molecule protoporphyrin IX. When irradiated with red light, protoporphyrin IX reacts with oxygen. This produces highly reactive oxygen species, free radicals, which destroy the cancer cells. Approximately ten minutes of red light irradiation is sufficient to successfully treat superficial forms of non-melanoma skin cancers such as actinic keratosis. Doctors also remove warts in this way.

Painful therapy

"The catch is: it's terribly painful", says Ben Novak. Forty percent of those treated experience pain during the light irradiation, which they assess on a scale of 0 to 10 (whereby 10 corresponds to an excruciating pain like a heart attack) as 7 to 8. Using injections, like at the dentist, it is possible to numb the nerves involved. "But that also always involves a risk", says the Bochum biologist. The scientists led by the RUB professor Dr. Hermann Lbbert have now solved the mystery as to why the treatment hurts at all.

Pain-sensitive cells in the s
'/>"/>

Contact: Dr. Ben Novak
Ben.Novak@rub.de
49-234-322-4331
Ruhr-University Bochum
Source:Eurekalert

Page: 1 2

Related biology news :

1. Green Oakley Cluster to double OSC computing power
2. Hammerhead shark double whammy
3. Heart study suggests city center pollution doubles risk of calcium build-up in arteries
4. Doubling the information from the double helix
5. Agricultural expert outlines path for developing nations to double food production, meet 2050 demand
6. Jurassic pain: Giant flea-like insects plagued dinosaurs 165 million years ago
7. IU biologists offer clearer picture of how protein machine systems tweak gene expression
8. Microbiologists can now measure extremely slow life
9. American Society of Plant Biologists honors early career women scientists
10. Penn biologists identify a key enzyme involved in protecting nerves from degeneration
11. University of Toronto biologists predict extinction for organisms with poor quality genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2015)... 13, 2015 Synaptics Inc. (NASDAQ: ... solutions, today announced sampling of ClearPad ® ... integration (TDDI) product targeting smartphones and tablets. This ... Synaptics , best-in-class touch controller IP and ... developed in the company,s Japan Design Center. TDDI ...
(Date:7/9/2015)... 9, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced a new Match-in-Sensor™ ... hardware encapsulated fingerprint sensor and matching solution. ... literally off the grid, isolating fingerprint image ... the fingerprint sensor to provide ultimate protection ...
(Date:7/7/2015)... 30, 2015 Research ... addition of the "Capacitive Fingerprint Sensors Patent ... To this date, fingerprint sensing technology is the ... sensors are well developed. This patent landscape focuses ... The domain of capacitive fingerprint sensors is ...
Breaking Biology News(10 mins):Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2
... Researchers from Stony Brook University Medical Center in New York ... ancient human species and not a descendant of healthy humans ... of a well-preserved female specimen, researchers determined the "hobbit" to ... of modern humans. Details of the study appear in ...
... are reporting discovery of unusual liver proteins, found only in ... the hepatitis B virus (HBV) sexually discriminates -- hitting men ... ACS, Journal of Proteome Research , a monthly publication. ... chronic hepatitis B seems to progress and cause liver damage ...
... Viruses are well known for attacking humans and animals, ... researchers are exploring how hungry viruses, armed with transformer-like ... of bacterial infections. , The Texas A&M researchers, work ... & Molecular Biology . , The attackers are called ...
Cached Biology News:'Hobbits' are a new human species -- according to the statistical analysis of fossils 2Texas A&M Researchers Examine How Viruses Destroy Bacteria 2
(Date:7/27/2015)... ... 2015 , ... BlueInGreen® announced the addition of EnviroSales of ... world’s most efficient gas dissolution technology to all of Florida, excluding the panhandle. ... and municipal markets. With offices located in Sarasota, Sebring and Melbourne Beach, the ...
(Date:7/27/2015)... ... July 27, 2015 , ... Visual Assay was named as ... top 100 most innovative technologies and services of the past year. More than 70 ... Software/Services category. The winners will be announced at the 2015 R&D 100 Awards Dinner ...
(Date:7/24/2015)... NEW YORK , July 24, 2015 ... the following equities: PDL BioPharma Inc. (NASDAQ: PDLI ... Inc. (NASDAQ: STEM ), Northwest Biotherapeutics Inc. (NASDAQ: ... ACOR ). Free research report on PDL BioPharma can ... 23, 2015, the NASDAQ Composite ended at 5,146.41, down ...
(Date:7/24/2015)... 24, 2015 , Adds integrated ... Expands product offering for chronic kidney disease and oncology ... diabetes-related complications and dermatology , Increases group revenue ... or ,the Company"), a leading China ... marketing biopharmaceutical products, today announced that it has acquired ...
Breaking Biology Technology:BlueInGreen Brings Water Treatment Technology to Florida 2Visual Assay® Named Finalist in 53rd Annual R&D 100 Awards 2Biotechnology Stocks in Motion -- PDL BioPharma, Arena Pharma, StemCells, Northwest Biotherapeutics, and Acorda Therapeutics 2Biotechnology Stocks in Motion -- PDL BioPharma, Arena Pharma, StemCells, Northwest Biotherapeutics, and Acorda Therapeutics 3Biotechnology Stocks in Motion -- PDL BioPharma, Arena Pharma, StemCells, Northwest Biotherapeutics, and Acorda Therapeutics 4Biotechnology Stocks in Motion -- PDL BioPharma, Arena Pharma, StemCells, Northwest Biotherapeutics, and Acorda Therapeutics 53SBio Acquires Zhejiang Wansheng Pharmaceutical 23SBio Acquires Zhejiang Wansheng Pharmaceutical 33SBio Acquires Zhejiang Wansheng Pharmaceutical 4
... Corp ., a Madison biotechnology company, has raised $1 million ... the total raised to $3 million in the past two ... verify the efficacy of two products: adhesives that bind tissues ... and medical device coatings that block bacterial adhesion to the ...
... - Sir Ken Robinson has many ... his point about creativity than the story of a little ... a senior advisor to the J. Paul Getty Trust ... creativity and innovation, told the story during a keynote address ...
... 1995, I gave a luncheon speech to the Chicago Bar ... st Century." At that time, many who attended ... that much faith in it. My argument was that the ... maxed out. Municipalities would have to become more creative to ...
Cached Biology Technology:Sir Ken Robinson: Companies, kids "get" innovation, but K-12 doesn't nurture it 2Sir Ken Robinson: Companies, kids "get" innovation, but K-12 doesn't nurture it 3Creativity, innovation extend to municipalities 2Creativity, innovation extend to municipalities 3Creativity, innovation extend to municipalities 4