Navigation Links
Double the pain: RUB biologists find the cause of pain in the treatment of fair skin cancer
Date:6/20/2012

Apply the ointment, light on, light off that's how easy it is to cure various forms of non-melanoma skin cancer. However, the majority of patients suffer severe pain during the so-termed photodynamic therapy. Why the treatment with ointment and red light can be so painful has now been uncovered by researchers from the RUB. They identified the ion channels involved and signalling molecules secreted by the cancer cells. "The results may provide a starting point for suppressing the pain", says Dr. Ben Novak of the Department of Animal Physiology.

How the photodynamic therapy works

In contrast to normal cells, cancer cells are equipped with different enzymes and have a much higher metabolism. If you apply a molecule called aminolevulinic acid to the skin in the form of a gel, cancer cells take up considerably more of this substance than healthy cells. If aminolevulinic acid accumulates in the cells, the mitochondria the power plants of the cells form the molecule protoporphyrin IX. When irradiated with red light, protoporphyrin IX reacts with oxygen. This produces highly reactive oxygen species, free radicals, which destroy the cancer cells. Approximately ten minutes of red light irradiation is sufficient to successfully treat superficial forms of non-melanoma skin cancers such as actinic keratosis. Doctors also remove warts in this way.

Painful therapy

"The catch is: it's terribly painful", says Ben Novak. Forty percent of those treated experience pain during the light irradiation, which they assess on a scale of 0 to 10 (whereby 10 corresponds to an excruciating pain like a heart attack) as 7 to 8. Using injections, like at the dentist, it is possible to numb the nerves involved. "But that also always involves a risk", says the Bochum biologist. The scientists led by the RUB professor Dr. Hermann Lbbert have now solved the mystery as to why the treatment hurts at all.

Pain-sensitive cells in the s
'/>"/>

Contact: Dr. Ben Novak
Ben.Novak@rub.de
49-234-322-4331
Ruhr-University Bochum
Source:Eurekalert

Page: 1 2

Related biology news :

1. Green Oakley Cluster to double OSC computing power
2. Hammerhead shark double whammy
3. Heart study suggests city center pollution doubles risk of calcium build-up in arteries
4. Doubling the information from the double helix
5. Agricultural expert outlines path for developing nations to double food production, meet 2050 demand
6. Jurassic pain: Giant flea-like insects plagued dinosaurs 165 million years ago
7. IU biologists offer clearer picture of how protein machine systems tweak gene expression
8. Microbiologists can now measure extremely slow life
9. American Society of Plant Biologists honors early career women scientists
10. Penn biologists identify a key enzyme involved in protecting nerves from degeneration
11. University of Toronto biologists predict extinction for organisms with poor quality genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... of sea ice melt in the summer and when sea ... and more reduced. As the Arctic summers are getting warmer ... sea ice in the Arctic will remove less CO2 from ... representative, then sea ice plays a greater role than expected, ... CO2 budgets", says Dorte Haubjerg Sgaard, PhD Fellow, Nordic Center ...
(Date:9/22/2014)... , Sept. 22, 2014 NXT-ID, Inc. ... focused on the growing mobile commerce market, issues the ... and the recent funding. Letter ... an essential round of funding and joined the NASDAQ ... as expand its other biometric and authentication products and ...
(Date:9/22/2014)... More than 7,000 geoscientists will gather in Vancouver, British ... Society of America,s 126th Annual Meeting & Exposition on ... as the transportation of crude oil, earthquake prediction problems, ... guide, Trials and Tribulations of Life on an Active ... Vancouver area. , A broad range of topics will ...
Breaking Biology News(10 mins):Arctic sea ice helps remove CO2 from the atmosphere 2NXT-ID Issues Shareholder Corporate Update 2NXT-ID Issues Shareholder Corporate Update 3NXT-ID Issues Shareholder Corporate Update 4Geoscience topics in the spotlight -- Vancouver, BC 2Geoscience topics in the spotlight -- Vancouver, BC 3Geoscience topics in the spotlight -- Vancouver, BC 4Geoscience topics in the spotlight -- Vancouver, BC 5
... bulges: people will gladly remove excess body fat to improve ... the potential to repair defects and heal injuries in the ... of Oslo in Norway has identified certain chemical marks that ... of stem cells in liposuctioned fat, are best at regenerating ...
... Specialist II, and Linheng Li, Ph.D., Associate Investigator, are the ... clarifies how normal stem cells become cancer stem cells and ... , The paper, "PTEN-deficient intestinal stem cells initiate intestinal ... January 21. , The theory that cancer stem cells ...
... out of three sexually active older adults infected with HIV ... researchers. A survey of 260 HIV-positive older adults found that ... were in a relationship. , AIDs cases among the over-50 ... Disease Control and Prevention, they will account for half of ...
Cached Biology News:Liposuctioned fat stem cells to repair bodies 2Linheng Li Lab documents the development of cancer stem cells 21/3 of sexually active older adults with HIV/AIDs has unprotected sex 2
(Date:9/22/2014)... California (PRWEB) September 22, 2014 ... primal desire to stay young has groomed and ... dollar industry worldwide. Growing emphasis on appearance maintenance ... Toxin is a neurotoxic protein obtained from the ... acetylcholine, resulting in muscle relaxation. With cosmetic indications ...
(Date:9/22/2014)... Research and Markets has announced ... Cellulose Industry Report 2014" report to their offering. ... Industry Report 2014 is a professional and in-depth study ... industry with a focus on the Chinese situation. ... industry including definitions, classifications, applications and industry chain structure. ...
(Date:9/22/2014)... (PRWEB) September 22, 2014 Invisible ... diagnostics for the food and beverage industries, announced ... be distributed under a non-exclusive agreement by Enartis, ... services. , Enartis, an Esseco Group company headquartered ... winemakers in California and other global markets for ...
(Date:9/22/2014)... and TORONTO , Sept. 22, ... ) (OTCBB:GNBT) today announced that it has entered ... pursuant to which UHN,s Centre for Molecular Design ... insulin refinement project.  The goal of the project ... Oral-lyn™, the Company,s proprietary buccal insulin spray product, ...
Breaking Biology Technology:Strong Demand for Non-Invasive Cosmetic Procedures Drives the Global Botulinum Toxin Market, According to New Report by Global Industry Analysts, Inc. 2Strong Demand for Non-Invasive Cosmetic Procedures Drives the Global Botulinum Toxin Market, According to New Report by Global Industry Analysts, Inc. 3Global and Chinese Microcrystalline Cellulose Industry Report 2014 2Invisible Sentinel's Test for Wine-Spoilage Microbe to be Distributed by Enartis in Multiple Markets Globally 2Invisible Sentinel's Test for Wine-Spoilage Microbe to be Distributed by Enartis in Multiple Markets Globally 3Generex Collaborates with University Health Network for Buccal Insulin Project 2Generex Collaborates with University Health Network for Buccal Insulin Project 3Generex Collaborates with University Health Network for Buccal Insulin Project 4
... 13 Nile Therapeutics, Inc.,(Nasdaq: NLTX ), today ... present at the Rodman & Renshaw 5th Annual Global ... at Le Meridian Beach,Plaza Hotel in Monte Carlo, Monaco. ... the status of Nile,s current clinical development,programs., The ...
... Foamix Offers New Intravaginal Foam Technology with Improved Usability & ... ... Israel, May 13 Despite the high incidence,of women,s health conditions ... and ovules, a recent survey,found that an alarming majority of women ...
... with CelVida Yields First Milestone, NEW YORK, May ... pioneering the pre-disease collection, processing and long-term,storage of adult ... a,site has been secured for a new stem cell ... Robin Smith, MD MBA, NeoStem,s Chairman and Chief ...
Cached Biology Technology:Nile Therapeutics to Present at the Rodman & Renshaw 5th Annual Global Healthcare Conference 272% of Women Are Dissatisfied With Their Current Treatment of Vaginal Infection, Survey Finds 2NeoStem to Expand Stem Cell Collection Center Network to Florida 2NeoStem to Expand Stem Cell Collection Center Network to Florida 3