Navigation Links
Double duty: Immune system regulator found to protect brain from effects of stroke
Date:11/28/2012

A small molecule known to regulate white blood cells has a surprising second role in protecting brain cells from the deleterious effects of stroke, Johns Hopkins researchers report. The molecule, microRNA-223, affects how cells respond to the temporary loss of blood supply brought on by stroke and thus the cells' likelihood of suffering permanent damage.

"We set out to find a small molecule with very specific effects in the brain, one that could be the target of a future stroke treatment," says Valina Dawson, Ph.D., a professor in the Johns Hopkins University School of Medicine's Institute for Cell Engineering. "What we found is this molecule involved in immune response, which also acts in complex ways on the brain. This opens up a suite of interesting questions about what microRNA-223 is doing and how, but it also presents a challenge to any therapeutic application." A report on the discovery is published in the Nov. 13 issue of the Proceedings of the National Academy of Sciences.

RNA is best known as a go-between that shuttles genetic information from DNA and then helps produce proteins based on that information. But, Dawson explains, a decade ago researchers unearthed a completely different class of RNA: small, nimble fragments that regulate protein production. In the case of microRNA, one member of this class, that control comes from the ability to bind to RNA messenger molecules carrying genetic information, and thus prevent them from delivering their messages. "Compared with most ways of shutting genes off, this one is very quick," Dawson notes.

Reasoning that this quick action, along with other properties, could make microRNAs a good target for therapy development, Dawson and her team searched for microRNAs that regulate brain cells' response to oxygen deprivation.

To do that, they looked for proteins that increased in number in cells subjected to stress, and then examined how production of these proteins was r
'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. DNAs double stranded stretch
2. Did a forgotten meteor have a deadly, icy double-punch?
3. Nanoparticles added to platelets double internal injury survival rate
4. Brain enzyme is double whammy for Alzheimers disease
5. New process doubles production of alternative fuel while slashing costs
6. Paddlefishs doubled genome may question theories on limb evolution
7. Double the pain: RUB biologists find the cause of pain in the treatment of fair skin cancer
8. Agricultural expert outlines path for developing nations to double food production, meet 2050 demand
9. Doubling the information from the double helix
10. Heart study suggests city center pollution doubles risk of calcium build-up in arteries
11. Hammerhead shark double whammy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)...  HITLAB SM announced today its completion of a ... to current U.S. Food and Drug Administration (FDA) regulations. ... and smart phone application trials utilizing the highest principles ... is determined to improve global healthcare access, quality, and ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of ...  report to their offering. One major ... With continuous advances in technology, it is important to ...
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Valencell, a leader ... is seeing a staggering demand from its licensees for ... Company revealed, is not solely coming from fitness and ... well. "A wearable is only as useful ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... chase down speeding vehicles as the movie Jurassic Park would ... certainly no slouch, research out today suggests. The University ... running speeds of five meat-eating dinosaurs that varied in size ... study believed to be the most accurate ever produced ...
... BOSTON Ever since the Manhattan project in ... nuclear science and technology. Yet,scientists still seek the ... of actinide compounds and materials using first principle ... to achievement. PNNL scientist Jun Li will ...
... 2007) Genetic testing can be used to help ... according to research published in the September 1, 2007, ... American Society of Hematology. This result represents one of ... to guide personal medical care. Because individuals metabolize ...
Cached Biology News:T. rex quicker than Becks, say scientists 2Genetics determine optimal drug dose of common anticoagulant 2
(Date:1/22/2015)... 22, 2015 Shimadzu Scientific Instruments ... multipurpose UV-visible spectrophotometer. Offering wavelength scanning from 190 ... ideal for applications in a variety of industries, ... The user-friendly UV-1280 enables intuitive operation, while the ...
(Date:1/22/2015)...  Transwestern | RBJ today announces the firm brokered a long-term ... a leading biopharmaceutical company, at Two Ledgemont Center in ... Richards , president, and Brian Cohen , senior vice ... building at 95 Hayden Ave. Photo - ...
(Date:1/22/2015)... Protocol Networks brings independent technology consulting ... brand-neutral, independent consultants, Protocol Networks has recently announced its ... the years, his company has attracted several clients in ... as well as others. With the success of these ...
(Date:1/22/2015)... 2015 zFlo Motion , a US ... an exciting product from a new partner. STT-Systems ... the past 15 years, with offerings in the optical-motion capture, ... IMU system (inertial measurement unit), iSen, is opening eyes around ...
Breaking Biology Technology:Shimadzu’s New Monitored Single-Beam UV-Vis Spectrophotometer Offers Comprehensive Measurement Options in a Compact Body 2Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 23D Motion Capture Just Got Easy 2
... 27 Soligenix, Inc., (Soligenix or the Company) (OTC ... a late-stage biotechnology company, announced today that its Chief ... highlighting recent developments at the BIO Investor Forum. , ... 2009 at 1:00 PM PDT at The Palace Hotel ...
... ... , ... October 27, 2009 -- Global food security, which is increasingly being recognized as a ... and private partnerships, William S. Niebur , vice president – DuPont Crop Genetics ...
... Cynosure, Inc. (Nasdaq: CYNO ), a leading developer and ... today announced financial results for the three and nine months ... Results , Revenues for the three months ended September ... the same period of 2008 and $20.8 million for the ...
Cached Biology Technology:Soligenix to Present at 8th Annual BIO Investor Forum 2Soligenix to Present at 8th Annual BIO Investor Forum 3Soligenix to Present at 8th Annual BIO Investor Forum 4Public-Private Partnerships Key to Achieving Global Food Security, Says DuPont Leader 2Public-Private Partnerships Key to Achieving Global Food Security, Says DuPont Leader 3Cynosure Reports Third Quarter 2009 Financial Results 2Cynosure Reports Third Quarter 2009 Financial Results 3Cynosure Reports Third Quarter 2009 Financial Results 4Cynosure Reports Third Quarter 2009 Financial Results 5Cynosure Reports Third Quarter 2009 Financial Results 6Cynosure Reports Third Quarter 2009 Financial Results 7Cynosure Reports Third Quarter 2009 Financial Results 8Cynosure Reports Third Quarter 2009 Financial Results 9Cynosure Reports Third Quarter 2009 Financial Results 10Cynosure Reports Third Quarter 2009 Financial Results 11Cynosure Reports Third Quarter 2009 Financial Results 12
... the translation boosting Cap 1 structure. mScript™ ... 40% to 80% capped using co-transcriptional systems) ... mScript™ also features the Cap 1 structure, ... to 50% more efficient in in vivo ...
...
Request Info...
... pPIC9K and pPIC3.5K vectors carry the kanamycin ... Reagent in Pichia. Spontaneous generation of multiple ... to increased levels of Geneticin Reagent. Pichia ... screened for their level of resistance to ...
Biology Products: