Navigation Links
Don't forget the vitamin A when working with its carrier protein
Date:9/26/2008

Vitamin A is an essential nutrient involved in vision, growth, cellular differentiation, and immune function. Because vitamin A is fat-soluble, it is chaperoned through the body on carrier proteins. Researchers at the University of Wisconsin-Madison in a study funded by USDA and NIH, discovered that not only was one of the carrier proteins for vitamin A, retinol-binding protein (RBP), elevated in obese individuals compared to leaner controls, but some of it was not attached to retinol, the main circulating form of the vitamin. RBP that is not bound to vitamin A is called apo-RBP by vitamin A scientists. Their study will appear in the October 08 issue of Experimental Biology and Medicine.

The research team led by Sherry Tanumihardjo, an associate professor of Nutritional Sciences, originally was interested in determining the degree of hypervitaminosis A in the cohort for preliminary data on excessive liver storage of the vitamin. Her graduate student, Jordan Mills, was interested in determining the retinol-binding protein concentrations. While the degree of hypervitaminosis A was remarkable at 4% prevalence for the obese cohort, the relationship of retinol to RBP was a more interesting discovery. The retinol to RBP ratio (retinol:RBP) was significantly lower in the obese subjects than nonobese subjects. This was attributable to more RBP circulating in the serum not bound to vitamin A. RBP was strongly associated with vitamin A in both groups, but more so in the nonobese individuals.

"A series of studies in mice and humans revealed a strong relationship between serum RBP and obesity-induced insulin resistance. While some studies validated these original observations of elevated RBP in obesity and insulin resistance in humans, others have not. Often lacking in these publications are data for serum retinol, arguably RBP's most important physiological companion, representing a possible explanation for conflicting results," said Mills.
'/>"/>

Contact: Sherry A. Tanumihardjo
sherry@nutrisci.wisc.edu
608-265-0792
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. When accounting for the global nitrogen budget, dont forget fish
2. Fighting Aussie yabbies dont forget a face -- new research by the University of Melbourne
3. Low vitamin D during pregnancy linked to pre-eclampsia
4. Low vitamin D linked to higher risk of hip fracture
5. Vitamin E trials fatally flawed
6. Study shows vitamin C is essential for plant growth
7. Could vitamin D, a key milk nutrient, affect how you age?
8. Vitamin B-12 function may be diminished by excessive folate
9. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
10. New way to produce high-vitamin corn could improve nutrition in developing countries
11. Team finds an economical way to boost the vitamin A content of maize
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... and plastic bags could one day be made out ... scientists are now reporting. The novel process they developed ... with its agricultural and plastic waste problems, appear in ... Ilker S. Bayer and colleagues at the Italian Institute ... growing. In 2012, its production reached 288 million tons ...
(Date:8/20/2014)... light and its energy is finally utilized for ... devices, mostly build from silicon based semiconductors, also ... for the development of cheaper and renewable photovoltaics ... membrane protein complexes of photosynthesis. Prof. Dr. Matthias ... thermophilic cyanobacteria that live in a hot spring ...
(Date:8/19/2014)... systems be used in supermarkets to encourage healthier spending ... to answer that very question by tracking the purchasing ... Stars System to rate the nutritional value of foods ... Brand Lab,s David Just, PhD, and Brian Wansink PhD, ... records of over 150 Hannaford Supermarkets in the Northeastern ...
Breaking Biology News(10 mins):A semi-artificial leaf faster than 'natural' photosynthesis 2
... Inflammation of gum tissues periodontitis is one of ... susceptible to diseases of the circulatory system, rheumatoid arthritis, ... of Jan Potempa, PhD, DSc, professor and academic scholar, ... School of Dentistry, have helped change scientific thinking about ...
... Ore. -- A constellation of defective proteins suspected in causing ... DNA could be the link scientists need to prove a ... broad range of ovarian cancer patients, an Oregon Health & ... results, published this week in PLoS ONE , have ...
... DC - On January 18, 2012, Dr. Peter ... National Homeland Security Research Center in the Office ... Protection Agency, will lead a session titled "National ... national resilience to bioterrorism threats involves maximizing advanced ...
Cached Biology News:UofL researcher earns the Foundation for Polish Science Prize 2Faulty proteins may prove significant in identifying new treatments for ovarian cancer 2
(Date:8/20/2014)... (PRWEB) August 20, 2014 The ... is being held on October 29-30 in San Francisco, ... industry, academic and government researchers and clinicians focused on ... space. , In the twelve years since the ... therapies have been introduced with pharmacogenetic information in the ...
(Date:8/20/2014)... GraphDB™ 6.0 from ... to the enterprise replication cluster, faster loading speeds, ... and Elasticsearch. This release happens to coincide with ... – GraphDB™ was formerly known as OWLIM. ... mature enterprise resilient RDF triplestore will also benefit ...
(Date:8/19/2014)... Cellgen Diagnostics today launched ... a corporate lab for its genetic-based medical testing ... a critical component in the move from today’s ... of personalized medicine – a more predictive, preventive, ... contributions will support Cellgen’s intent to develop the ...
(Date:8/19/2014)... BURNIE, Md. , Aug. 19, 2014 ... clinical research industry, recently announced the formation of the ... pleased to announce the addition of Dr. William ... Photo - http://photos.prnewswire.com/prnh/20140818/136957 The ... across a variety of therapeutic areas and set strategic ...
Breaking Biology Technology:6th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 2CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 3
... , MONTRÉAL, Jan. 19 /PRNewswire-FirstCall/ - ... established a Special Committee of independent Board members to explore ... a sale of the Company or the sale of all ... be working with management and external consultants to expeditiously make ...
... ... of integration, functionality, innovation, manageability, performance and value provided to end users. , ... (PRWEB) January 19, 2010 ... Silver Award for Virtualization Management. This annual award identifies the companies ...
... NEW HAVEN, Conn. , Jan. 19 ... Richard J. Carroll to the newly created position ... HistoRx over 20 years of sales, marketing, research, and general ... Before joining HistoRx in 2009, he was Vice President of ...
Cached Biology Technology:ConjuChem to evaluate strategic alternatives 2VKernel's Optimization Pack Wins Award In SearchServerVirtualization.Com's 2009 Products of the Year Survey 2HistoRx Names Dick Carroll, Ph.D. as VP of Clinical Research 2HistoRx Names Dick Carroll, Ph.D. as VP of Clinical Research 3