Navigation Links
Don't forget the vitamin A when working with its carrier protein
Date:9/26/2008

Vitamin A is an essential nutrient involved in vision, growth, cellular differentiation, and immune function. Because vitamin A is fat-soluble, it is chaperoned through the body on carrier proteins. Researchers at the University of Wisconsin-Madison in a study funded by USDA and NIH, discovered that not only was one of the carrier proteins for vitamin A, retinol-binding protein (RBP), elevated in obese individuals compared to leaner controls, but some of it was not attached to retinol, the main circulating form of the vitamin. RBP that is not bound to vitamin A is called apo-RBP by vitamin A scientists. Their study will appear in the October 08 issue of Experimental Biology and Medicine.

The research team led by Sherry Tanumihardjo, an associate professor of Nutritional Sciences, originally was interested in determining the degree of hypervitaminosis A in the cohort for preliminary data on excessive liver storage of the vitamin. Her graduate student, Jordan Mills, was interested in determining the retinol-binding protein concentrations. While the degree of hypervitaminosis A was remarkable at 4% prevalence for the obese cohort, the relationship of retinol to RBP was a more interesting discovery. The retinol to RBP ratio (retinol:RBP) was significantly lower in the obese subjects than nonobese subjects. This was attributable to more RBP circulating in the serum not bound to vitamin A. RBP was strongly associated with vitamin A in both groups, but more so in the nonobese individuals.

"A series of studies in mice and humans revealed a strong relationship between serum RBP and obesity-induced insulin resistance. While some studies validated these original observations of elevated RBP in obesity and insulin resistance in humans, others have not. Often lacking in these publications are data for serum retinol, arguably RBP's most important physiological companion, representing a possible explanation for conflicting results," said Mills.
'/>"/>

Contact: Sherry A. Tanumihardjo
sherry@nutrisci.wisc.edu
608-265-0792
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. When accounting for the global nitrogen budget, dont forget fish
2. Fighting Aussie yabbies dont forget a face -- new research by the University of Melbourne
3. Low vitamin D during pregnancy linked to pre-eclampsia
4. Low vitamin D linked to higher risk of hip fracture
5. Vitamin E trials fatally flawed
6. Study shows vitamin C is essential for plant growth
7. Could vitamin D, a key milk nutrient, affect how you age?
8. Vitamin B-12 function may be diminished by excessive folate
9. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
10. New way to produce high-vitamin corn could improve nutrition in developing countries
11. Team finds an economical way to boost the vitamin A content of maize
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... one of the amphibians with the highest distribution in ... of water where it comes into contact with the ... carried out by the Spaniard Germn Orizaola from the ... these frogs have developed a defensive response to the ... bodies if they co-exist with the crayfish. , Numerous ...
(Date:7/9/2014)... function and increase the survival rate of naturally ... School of Pharmaceutical Sciences, Southwest University, China performed ... administered with low dose of levothyroxine for 3 ... exhibited an obvious improvement in cognitive and an ... The underlying mechanism was demonstrated that levothyroxine treatment ...
(Date:7/9/2014)... vitamin D in their blood are more likely to survive ... highest levels of vitamin D have half the risk of ... reveal. , The study is the first to correlate total ... their diagnosis which includes that produced after exposure to ... long term survival prospects. , The University of Edinburgh ...
Breaking Biology News(10 mins):Frogs have developed rapid defences against the red swamp crayfish 2Frogs have developed rapid defences against the red swamp crayfish 3
... is helping to reduce the drug cravings of addicted rats. ... some parts of the brain lose glutamate receptors from the ... neurons. The researchers have sidestepped this problem by crafting a ... glutamate receptor and, once inside a neuron, serves as a ...
... discovered in tiny snow fleas by Queen's University researchers ... transplantation. , Drs. Laurie Graham and Peter Davies, from ... produced by the fleas to protect themselves against freezing ... Celsius degrees. This would allow organs to be stored ...
... zebrafish may be able to play a critical role in ... that can lead to it - and identified one gene ... , The findings were published in a professional journal, Proceedings ... State University and two Boston hospitals, the Brigham and Women's ...
Cached Biology News:Grabbing addiction by the tail 2Grabbing addiction by the tail 3New antifreeze protein found in fleas may allow longer storage of transplant organs 2Zebrafish may hold key to improved cancer research 2Zebrafish may hold key to improved cancer research 3
(Date:1/15/2014)... 15, 2014  Bill Jacobs Automotive, a group of car dealerships ... with the Heartland Blood Center and offering free oil change ... takes place Saturday, Jan. 18 at the Bill Jacobs Cadillac ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill ...
(Date:1/15/2014)... California , January 15, 2014 Oxford ... today announced the appointment of Thomas C Reynolds MD, PhD ... years, development experience gained in the biotechnology industry, most recently ... am delighted to welcome Tom at this transformative time for ...
(Date:1/15/2014)... Two champions of science, technology, engineering, ... an annual competition for middle and high school students ... STEM study. The competition presents students with real-world problems ... Aptitude, Mathematics, and Sciences is a program administered ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 AudioNotch is ... new therapy for the treatment of tinnitus. Patients listen ... frequency, and over a period of weeks to months, their ... Therapy in two forms: Notched Music and Notched White Noise. ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5
... 9 The results of a new study on immune-based ... sites around the country, will be published in the December ... MD, MS, director of the Butler Hospital Memory and Aging ... Warren Alpert Medical School of Brown University, says that this ...
... , , QUEBEC CITY, Dec. 9 /PRNewswire-FirstCall/ ... AEZ) (the "Company"), a global biopharmaceutical company focused on ... appointment of Pierre Lapalme to its Board of Directors. ... has over the course of his career held numerous ...
... , OXFORD, England, December ... Recent Recruitment of Senior Antibody Industry,Leaders and Highlights OBT,s Growth ... Oxford BioTherapeutics (OBT) has today announced the appointment of ... experience to OBT at an exciting phase in the Company,s,development, ...
Cached Biology Technology:Butler Hospital Neurologist Lead Author of Ground Breaking Bio-Engineered Treatment Study for Alzheimer's Disease 2AEterna Zentaris Announces Appointment of New Board Member 2Oxford BioTherapeutics Appoints Michael Moore as Chairman 2Oxford BioTherapeutics Appoints Michael Moore as Chairman 3Oxford BioTherapeutics Appoints Michael Moore as Chairman 4
Anti-CD74 Monoclonal Antibody Description: 200 l Research Focus: cell surface antigens Storage: 4C Shipping Temperature: 4C...
POU domain, class 2, transcription factor 2,...
HSPBP1 Antibody...
golgi reassembly stacking protein 2, 55kDa...
Biology Products: