Navigation Links
Domoic acid from toxic algal blooms may cause seizures in California sea lions
Date:6/9/2008

Scientists, reporting in the current issue of the online journal Marine Drugs, state that an increase of epileptic seizures and behavioral abnormalities in California sea lions can result from low-dose exposure to domoic acid as a fetus. The findings follow an analysis earlier this year led by Frances Gulland of the California Marine Mammal Center that showed this brain disturbance to be a newly recognized chronic disease.

John Ramsdell of NOAA's Center for Environmental Health and Biomolecular Research in Charleston, SC, in partnership with Tanja Zabka, a veterinary pathologist at the Marine Mammal Center, conducted the first-of-its kind analysis of poisoning by the algal toxin, domoic acid, during fetal brain development. The results, analyzed across multiple animal species, point to the toxin as a cause for behavioral changes and epilepsy that does not become evident until later in life.

Domoic acid is produced by harmful algal blooms. The algae is consumed by fish such as sardines, herring and anchovies, a significant part of the sea lion diet. Exposure during pregnancy concentrates the domoic acid toxin in the mother's amniotic fluid, which normally protects and aids in the growth of a fetus. In sea lions exposed to domoic acid, the fluid retains the toxin, thus subjecting the fetus to repeated direct absorption through immature skin cells and swallowing during gestation.

The results, demonstrated experimentally in laboratory animals and projected to occur in fetal sea lions, is abnormal development of brain neurons which does not impact the animal until it enters later life stages. This phenomenon, known as "fetal basis to adult disease," is expressed through seizures and abnormal behavioral changes.

"This represents a significant break through in understanding the origins of this behavior and will help us better understand the long-term consequences of exposure to harmful algal blooms during pregnancy,"
'/>"/>

Contact: Ben Sherman
ben.sherman@noaa.gov
301-713-3066
NOAA Headquarters
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetic differences in clover make one type toxic
2. UT researcher earns $1.3M grant to study toxic cleanup at DOD sites
3. Scientists ramp up ability of poplar plants to disarm toxic pollutants
4. Toxic releases down from North American industry leaders, increasing from other facilities
5. A search for protection against chemotherapy cardiotoxicity
6. New chemical tool kit manipulates mitochondria, reveals insights into drug toxicity
7. Motor neuron disease and toxic substances: Possible link?
8. Dental chair a possible source of neurotoxic mercury waste
9. First orchid fossil puts showy blooms at some 80 million years old
10. Cornell patents a pink lily look-alike that blooms all summer long
11. Scientists discover stinging truths about jellyfish blooms in the Bering Sea
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 16, 2014  Automation is fundamentally transforming the ... than at international borders. Over the past decade, ... allowed veteran travelers to self process through border ... Kiosks at an increasing number of airports, seaports, ... According to Maxine Most , Principal ...
(Date:12/11/2014)... 10, 2014  That blood pressure plays a role in ... – the medical term for high blood pressure – was ... the inflatable cuff that,s used in measuring blood pressure was ... nothing new about hypertension, its triggers and its effects. In ... condition and the best ways to treat it. ...
(Date:12/10/2014)... 2014  Wake Forest Baptist Medical Center today announced plans ... of Medicine. Funding for this $50 million capital project ... be publicly launched next summer. The ... 60 series R.J. Reynolds Tobacco Company complex, adjacent to ... immediately with plans to be ready to welcome medical ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... Graeme Ian Bell, PhD, the Louis Block Distinguished Service ... in the Kovler Diabetes Center at the University of ... for 2012 for his pioneering work in understanding the ... diabetes. The prize, the world,s largest award ...
... Mak Saito, a biogeochemist at Woods Hole Oceanographic Institution, has ... by the Gordon and Betty Moore Foundation. Saito is one ... funds from a total of up to $35 million over ... marine microbial ecology. "We are grateful to the Moore ...
... Wilmington, DE This month, Molecular Pharmaceutics ... for Childhood Cancer Research and the Materials Science ... about the potential for nanotechnology to deliver chemotherapeutic ... without harming healthy cells. To date, nanoparticle-based drug ...
Cached Biology News:University of Chicago's Graeme Bell receives international diabetes prize 2University of Chicago's Graeme Bell receives international diabetes prize 3WHOI scientist receives marine microbiology initiative investigator award from Moore Foundation 2Nanotechnology drug delivery shows promise for treatment of pediatric cancer 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... (Nasdaq: MATK ) announced today that it will ... Pharmaceuticals Conference in,London. The conference is being held May ... Steve Dubin, CEO will be presenting on Wednesday,May 28, ... Interested parties may access a live audio webcast ...
... the news release, "Rosetta Genomics Reports First Quarter 2008,Financial ... Rosetta Genomics Ltd,nasdaq:ROSG over PR Newswire, we are advised ... the conference call, as stated beneath the header,Conference Call ... ET,as previously issued. Complete, corrected release follows:, , ...
... YORK, May 21 Citing increasing demand for a ... Dr. Lance H. Brown has expanded his Manhattan practice ... His telephone number,there is 631-725-1771., As summer draws ... of too many seasons in the sun. Those seeking ...
Cached Biology Technology:/C O R R E C T I O N -- Rosetta Genomics Ltd/ 2/C O R R E C T I O N -- Rosetta Genomics Ltd/ 3/C O R R E C T I O N -- Rosetta Genomics Ltd/ 4/C O R R E C T I O N -- Rosetta Genomics Ltd/ 5/C O R R E C T I O N -- Rosetta Genomics Ltd/ 6/C O R R E C T I O N -- Rosetta Genomics Ltd/ 7/C O R R E C T I O N -- Rosetta Genomics Ltd/ 8/C O R R E C T I O N -- Rosetta Genomics Ltd/ 9/C O R R E C T I O N -- Rosetta Genomics Ltd/ 10/C O R R E C T I O N -- Rosetta Genomics Ltd/ 11/C O R R E C T I O N -- Rosetta Genomics Ltd/ 12/C O R R E C T I O N -- Rosetta Genomics Ltd/ 13/C O R R E C T I O N -- Rosetta Genomics Ltd/ 14/C O R R E C T I O N -- Rosetta Genomics Ltd/ 15/C O R R E C T I O N -- Rosetta Genomics Ltd/ 16/C O R R E C T I O N -- Rosetta Genomics Ltd/ 17/C O R R E C T I O N -- Rosetta Genomics Ltd/ 18/C O R R E C T I O N -- Rosetta Genomics Ltd/ 19/C O R R E C T I O N -- Rosetta Genomics Ltd/ 20Board Certified Dermatologist and President-Elect of the Dermatologic Society of Greater New York, Dr. Lance H. Brown Takes His Comprehensive Practice to East Hampton, NY 2
... (6-28) (human, bovine, porcine, rat) ... (VIP) receptor antagonist. This carboxy-terminal ... be twofold more potent than ... antagonists. Storage: ...
Protein 3D structure prediction, via threading. Easy to use....
L1 Protein of Human Papilloma Virus Purified Anti-Viral-transformed cells clone CAMVIR-1, Isotype Mouse IgG 2a , 0.1 mg Consult technical datasheet for details....
ANTI 5-HYDROXYTRYPTOPHAN CONJ....
Biology Products: