Dominant cholesterol-metabolism ideas challenged by ne...(ver to support the popular hypothesis th...)

Date:8/15/2007

ver to support the popular hypothesis that the ABCA1enzyme catalyzes the movement of PS across the cell membrane to the outer surface of the cell. Yet because Tangier patients and the knock-out mice experience a serious build-up of LDL in the tissues, we know that ABCA1 plays an important role in the cholesterol metabolism. Since none of our experimental results were consistent with the hypothesis that ABCA1 influences the first step in the process -- the transport of phospholipids to the cell surface -- we think that ABCA1 must operate in the second step, when the phospholipids are loaded onto the apoA1."

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Contact: Barbara K. Kennedy science@psu.edu 814-863-4682 Penn State Source:Eurekalert

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