Navigation Links
Dominant cholesterol-metabolism ideas challenged by new research
Date:8/15/2007

A team of researchers investigating cholesterol and lipid transport has performed experiments that cast serious doubt on the dominant hypothesis of how the body rids its cells of "bad" cholesterol (LDL) and increases "good" cholesterol (HDL). Cholesterol metabolism is an area of intense inquiry because high levels of LDL cholesterol or total cholesterol put about half of all Americans at significant risk of heart disease.

The team was led by Robert A. Schlegel, Professor of Biochemistry and Molecular Biology at Penn State University, and Patrick Williamson, the Edward S. Harkness Professor of Biology at Amherst College. The paper by Schlegel, Williamson, and their colleagues will be published on Wednesday, 15 August 2007, in the on-line journal PLoS One.

A protein called ABCA1 is critical for producing "good" cholesterol: patients who lack the gene for this protein produce no HDL, and as a result, suffer from heart attacks at an early age. An important question is what ABCA1 does that is so important for producing HDL.

The most popular hypothesis was put forth in 2000 by Giovanna Chimini, Group Leader of a laboratory in the Centre d'Immunologie Marseille-Luminy in France, and colleagues. They suggested that the ABCA1 enzyme plays a major role in the transfer of a phospholipid called phosphatidylserine (PS) from the inside of the cell -- where it is normally concentrated -- across the cell membrane to the outer surface of the cell. This is a crucial first step in the mechanism by which excess lipids and cholesterol are eliminated from the body. Under normal conditions, there is a second important step. After the PS is expressed on the cell surface, the phospholipids and excess cholesterol can be loaded onto a circulating protein, apoA1, to generate an HDL cholesterol particle. HDL cholesterol carries the lipids through the blood stream to the liver, where they are dumped into the in
'/>"/>

Contact: Barbara K. Kennedy
science@psu.edu
814-863-4682
Penn State
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Past experience of pheromones induces dominant courtship behavior in fruit flies
2. Dominant meerkats render rivals infertile
3. Agriculture and tropical conservation: rethinking old ideas
4. Researchers discover way to make cells in the eye sensitive to light
5. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
6. Columbia research lifts major hurdle to gene therapy for cancer
7. Researchers find how protein allows insects to detect and respond to pheromones
8. Researchers Uncover Key Step In Manufacture of Memory Protein
9. Research advances quest for HIV-1 vaccine
10. Research on Worms Yields Clues on Aging
11. U of M researcher examines newly emerging deadly disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... to species, selection for traits that are attractive to ... enhances opportunities to mate, the tail of male peacocks ... of California, Riverside have now found that sexual selection ... are linked. Describing the life histories of more than ... researchers found that species with placentas tend to have ...
(Date:7/9/2014)... critically ill children with traumatic injuries have identified ... likely to develop a hospital-acquired infection. The study, ... published online in June in the journal ... that could lead to the clinical implementation of ... or reverse immune system damage following critical illness ...
(Date:7/9/2014)... 100 diseases that can attack soybean crops, why would ... wanted list? University of Illinois scientists cite the earth,s ... needed on the fungus that causes charcoal rot. , ... conditions but Macrophomina phaseolina , the fungus that ... , "As the climate continues to change and we ...
Breaking Biology News(10 mins):Biologists link sexual selection and placenta formation 2Biologists link sexual selection and placenta formation 3Biologists link sexual selection and placenta formation 4Immune function predicts infection risk among child trauma patients 2Immune function predicts infection risk among child trauma patients 3Climate change provides good growing conditions for charcoal rot in soybeans 2Climate change provides good growing conditions for charcoal rot in soybeans 3
... EUREKA Chairmanship 2009/2010! The conference, hosted and conceptually designed ... be held on July 6-7, 2009, at Maritim Hotel ... heart of the city, only a few steps away ... the current and future opportunities and challenges for Europe,s ...
... used by millions worldwide to effectively lower blood cholesterol ... Sclerosis (MS) patients treated with high daily dosages. ... Institute (MNI), McGill University, demonstrates that statin therapy in ... nervous system. The findings, published in The American ...
... to model in mice because their symptoms are complex ... when transferred to a mouse. The lack of animal ... By strategically altering a protein-making molecule, a mouse was ... feeling and cause paralysis of the arms and legs ...
Cached Biology News:One size does not fit all 2A new mouse model provides insight into genetic neurological disorders 2
(Date:1/15/2014)... 15, 2014 More than 5 million ... 1 in 3 seniors will die with Alzheimer’s or ... jaw-dropping figures have shocked many Americans into looking for ... prevent these tragic age-related cognitive disorders. Jonathan Weisman, president ...
(Date:1/15/2014)... January 15, 2014 The Microcompetition with Foreign ... disease. One of these latent viruses is the Epstein Barr ... (RA). Rheumatoid arthritis (RA) is a chronic inflammatory disease that ... study found that RA patients have high concentrations of EBV ...
(Date:1/15/2014)... 2013 was a banner year of continued innovation ... continued independent research led by the team at Wake ... million grant from the Susanne Marcus Collins Foundation, had ... reviewed journal, Amy Grant highlighted Brainwave Optimization® in First ...
(Date:1/15/2014)... ON (PRWEB) January 15, 2014 AudioNotch ... experimental new therapy for the treatment of tinnitus. Patients ... tinnitus frequency, and over a period of weeks to months, ... Sound Therapy in two forms: Notched Music and Notched White ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... Fla., Oct. 7 GeneWize Life Sciences ... Bulletin Board: GNLK) announced before a full house of ... targeting the teen market, adding to their current flagship ... The new nutrition and skin-clearing products, aimed ...
... BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ... Executive Officer of BioMarin, will host a ... 28, at 5:00 p.m. ET to discuss ... Dial-in Number:  866.202.3048International Dial-in Number:  617.213.8843Participant Code: ...
... JOSEPH, Mich., Oct. 7 GeneGo, Inc., a leading ... and chemistry, announced today that they have integrated GenomeQuest,s ... MetaDrug. Using GenomeQuest,s interactive analysis, scientists who ... of interest (hundreds of millions of reads, to thousands ...
Cached Biology Technology:GeneWize Announces New Skin Clearing Product and Teen Nutrition at Annual Convention 2BioMarin to Host Third Quarter 2010 Financial Results Conference Call and Webcast on Thursday, October 28 at 5:00 p.m. ET 2GeneGo Announces Integration With GenomeQuest for Pathway Analysis of Next Generation Sequencing Data 2
Request Info...
2 ml SmartScan Racks...
... Immunogen: Partially purified ... MA1-710 detects vitamin D receptor (VDR) ... amphibian, and fish tissues. This ... or glucocorticoid receptors. MA1-710 detects ...
... The integration of 2D polyacrylamide gel electrophoresis ... regarded as a core technology platform for ... power for complex samples limited only in ... small and large proteins. Quantitative image based ...
Biology Products: