Navigation Links
Dominant cholesterol-metabolism ideas challenged by new research
Date:8/15/2007

A team of researchers investigating cholesterol and lipid transport has performed experiments that cast serious doubt on the dominant hypothesis of how the body rids its cells of "bad" cholesterol (LDL) and increases "good" cholesterol (HDL). Cholesterol metabolism is an area of intense inquiry because high levels of LDL cholesterol or total cholesterol put about half of all Americans at significant risk of heart disease.

The team was led by Robert A. Schlegel, Professor of Biochemistry and Molecular Biology at Penn State University, and Patrick Williamson, the Edward S. Harkness Professor of Biology at Amherst College. The paper by Schlegel, Williamson, and their colleagues will be published on Wednesday, 15 August 2007, in the on-line journal PLoS One.

A protein called ABCA1 is critical for producing "good" cholesterol: patients who lack the gene for this protein produce no HDL, and as a result, suffer from heart attacks at an early age. An important question is what ABCA1 does that is so important for producing HDL.

The most popular hypothesis was put forth in 2000 by Giovanna Chimini, Group Leader of a laboratory in the Centre d'Immunologie Marseille-Luminy in France, and colleagues. They suggested that the ABCA1 enzyme plays a major role in the transfer of a phospholipid called phosphatidylserine (PS) from the inside of the cell -- where it is normally concentrated -- across the cell membrane to the outer surface of the cell. This is a crucial first step in the mechanism by which excess lipids and cholesterol are eliminated from the body. Under normal conditions, there is a second important step. After the PS is expressed on the cell surface, the phospholipids and excess cholesterol can be loaded onto a circulating protein, apoA1, to generate an HDL cholesterol particle. HDL cholesterol carries the lipids through the blood stream to the liver, where they are dumped into the in
'/>"/>

Contact: Barbara K. Kennedy
science@psu.edu
814-863-4682
Penn State
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Past experience of pheromones induces dominant courtship behavior in fruit flies
2. Dominant meerkats render rivals infertile
3. Agriculture and tropical conservation: rethinking old ideas
4. Researchers discover way to make cells in the eye sensitive to light
5. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
6. Columbia research lifts major hurdle to gene therapy for cancer
7. Researchers find how protein allows insects to detect and respond to pheromones
8. Researchers Uncover Key Step In Manufacture of Memory Protein
9. Research advances quest for HIV-1 vaccine
10. Research on Worms Yields Clues on Aging
11. U of M researcher examines newly emerging deadly disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... , Jan. 27, 2015   Marvin ... globally deployed, innovative test solutions for military, ... delivery of its TS-323 GENASYS Test ... Company (LMSSC). GENASYS is a high-performance PXI-based ... mission-critical applications that require performance functional testing. ...
(Date:2/5/2015)... Feb. 3, 2015 Despite a lack ... industries such as consumer electronics, automotive, storage and ... mount technology (SMT) screen printers. Innovations in electronics ... will push the adoption curve up. Meanwhile, sale ... as glue dispensers are indispensable in the production ...
(Date:1/22/2015)... Hall E -   EyeLock Inc. , a market leader ... its EyeLock ID technology integrated in a 3D printed automobile ... Ridge National Laboratory (ORNL) at the 2015 North ... is being used to validate the driver and authorize the ...
Breaking Biology News(10 mins):Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 4End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 2End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 3EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3
... uncanny ability to detect electrical signals while hunting and ... those electrosensory powers to the same type of embryonic ... features in humans. , The discovery, reported by University ... & Development, identifies neural crest cells, which are common ...
... Studies have identified an important circuit in the spinal ... muscles contract and relax. Their findings mark an important ... movements - one of the main obstacles in developing ... circuits are important and understanding how they control the ...
... Comparative Functional Genomics and the University of California, Berkeley ... of microRNA (miRNA) targets in the animal model organism, ... (mRNA) in a specific section, called 3'UTR, and are ... were confirmed through the development of a novel in ...
Cached Biology News:UF scientists trace origin of shark's electric sense 2UF scientists trace origin of shark's electric sense 3Salk researchers make fast strides towards understanding how our body controls walking 2Biologists develop genome-wide map of miRNA-mRNA interactions 2
(Date:2/26/2015)... , Feb. 26, 2015  NuGene International, Inc. ... products for skin and hair rejuvenation, has announced ... agency of record for investor relations and strategic ... our distribution, sales and diversification strategies – and ... and prospective shareholders," stated Ali Kharazmi CEO of ...
(Date:2/26/2015)... 2015 Already well respected for accuracy, ... expanding its Length Gauge offerings with new variants of ... , Specifically, HEIDENHAIN’s pencil probe-style SPECTO length gauge series ... Two new 1Vpp, 12mm stroke length variants of the ... is a variant with a weak spring, 0.4N of ...
(Date:2/26/2015)... JUPITER, Fla. , Feb. 26, 2015 /PRNewswire/ ... biotechnology company whose patented and proprietary technologies are ... other proteins for the bioenergy, bio-based chemical, biopharmaceutical ... will report its financial results for year ending ... March 11, 2015 and will host a conference ...
(Date:2/26/2015)...  Epic Sciences announced today that President and CEO ... 35th Annual Cowen and Company Health Care Conference on Wednesday, ... 3rd Floor. The conference will be held at the ... Epic is developing diagnostic tests of high clinical utility ... that occur during the course of cancer treatments. From ...
Breaking Biology Technology:NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 2NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 3Accuracy and Versatile Gauging Go Hand in Hand at HEIDENHAIN 2Dyadic International To Announce Fourth Quarter 2014 Financial Results And Host Conference Call On Wednesday, March 11, 2015 2Dyadic International To Announce Fourth Quarter 2014 Financial Results And Host Conference Call On Wednesday, March 11, 2015 3Epic Sciences to Present at 35th Annual Cowen and Company Health Care Conference 2
... Sept. 1, 2011 Asmacure Ltee, a clinical-stage ... receptor agonists for the treatment of asthma and ... Driscoll will present at the 2011 BioPharm America ... provide an overview of Asmacure,s nicotinic acetylcholine receptor ...
... Sept. 1, 2011 Veracyte, Inc., a molecular diagnostics ... announced that new data from researchers at Johns Hopkins ... its Afirma® Gene Expression Classifier for clarifying inconclusive results ... improve patient care and save the healthcare system money. ...
... 1, 2011 The age-old fascination with machines ... fiction literature and cinema, mainly because authors and ... robots" since none had been built yet. According ... largest professional technical association, the distinction between science ...
Cached Biology Technology:Asmacure Ltee to Present at the 2011 BioPharm America Conference 2New Data Suggest Veracyte's Afirma® Gene Expression Classifier Cost-Effectively Resolves Inconclusive Thyroid Nodule FNA Biopsy Results 2New Data Suggest Veracyte's Afirma® Gene Expression Classifier Cost-Effectively Resolves Inconclusive Thyroid Nodule FNA Biopsy Results 3Mind-Controlled Bionic Limbs Holding Promise, and the Demand is Growing say IEEE Experts 2Mind-Controlled Bionic Limbs Holding Promise, and the Demand is Growing say IEEE Experts 3Mind-Controlled Bionic Limbs Holding Promise, and the Demand is Growing say IEEE Experts 4
... DASGIP Overhead Drive for individual and ... for flexible agitation of DASGIP vessels, featuring ... impellers. ,Up to 16 overhead drives ... DASGIP Cultivation Systems fedbatch-pro® and cellferm-pro® for ...
This kit is designed to select cells labeled with biotinylated antibodies. Kit includes reagents for labeling 3 x 10 9 cells and EasySep magnet....
Designed for use with the Agencourt CleanSEQ and Agencourt AMPure 384-well SPRI reagent kits. For use with 384-well thermal cycling plates....
SDS-OutT Precipitation Reagent...
Biology Products: