Navigation Links
Does the brain become unglued in autism?
Date:12/11/2012

Philadelphia, PA, December 11, 2012 A new study published in Biological Psychiatry suggests that autism is associated with reductions in the level of cellular adhesion molecules in the blood, where they play a role in immune function.

Cell adhesion molecules are the glue that binds cells together in the body. Deficits in adhesion molecules would be expected to compromise processes at the interfaces between cells, influencing tissue integrity and cell-to-cell signaling. In the brain, deficits in adhesion molecules could compromise brain development and communication between nerve cells.

Over the years, deficits in neural cell adhesion molecules have been implicated in schizophrenia and other psychiatric disorders. One adhesion molecule, neurexin, is strongly implicated in the heritable risk for autism.

Cell adhesion molecules also play a crucial role in regulating immune cell access to the central nervous system. Prior research provided evidence of immune system dysfunction in individuals diagnosed with autism spectrum disorder (ASD). This led scientists from the University of California, Davis to examine whether adhesion molecules are altered in children with ASD.

To conduct the study, they recruited 2-4 year old children, 49 of whom were diagnosed with an ASD and 31 of whom were typically developing. They measured blood plasma levels of multiple molecules, conducted behavioral assessments, and measured head circumference in all participants.

"For the first time, we show that levels of soluble sPECAM-1 and sP-selectin, two molecules that mediate leukocyte migration, are significantly decreased in young children with ASD compared with typically developing controls of the same age," explained the authors. "This finding is consistent with previous reports of decreased levels of both sPECAM-1 and sP-selectin in adults with high-functioning autism."

They also found that repetitive behavior scores and sPEC
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. How the common cat parasite gets into the brain
2. Research shows immune system response is detrimental to novel brain cancer therapy
3. Musical duets lock brains as well as rhythms
4. Double duty: Immune system regulator found to protect brain from effects of stroke
5. University of Maryland School of Medicine, NIH study pinpoints brain areas role in learning
6. Multiple sclerosis immune exchange between brain and blood is uncovered
7. A 3-D light switch for the brain
8. Neurons made from stem cells drive brain activity after transplantation in laboratory model
9. Brain waves make waves
10. New brain gene gives us edge over apes, study suggests
11. Watching the developing brain, scientists glean clues on neurological disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 15, 2014 Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ... Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a ... introduces for the first time a fingerprint sensor in ...
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM announced today ... to confirm its adherence to current U.S. Food and ... conduct regulated smart device and smart phone application trials ... quality. "HITLAB is determined to improve global ...
(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ( ... "Global Chemical Sensor Market 2015-2019" report to their ... One major trend upcoming in this market is ... Chemical sensors help in recording of patient data for ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... has discovered that bacteria,s move from sea to land ... has revealed that the bacteria may be especially useful ... National Laboratory joint faculty professor of microbiology and researcher ... genome sequence analysis of the soil bacteria Azospirillum, a ...
... professor in the Biochemistry and Biophysics Department within the ... Francisco has been awarded the 2012 Paul Ehrlich and ... the field of cell biology." The 100,000 ... two decades on how cells cope with stressinsight that ...
... sildenafil, the active ingredient in Viagra, can alleviate heart ... colleagues from the Mayo Clinic in Rochester (Minnesota) in ... failure, a condition in which the heart chamber does ... sildenafil makes stiffened cardiac walls more elastic again. The ...
Cached Biology News:UT-ORNL research reveals aquatic bacteria more recent move to land 2UCSF biochemist wins prestigious prize 2UCSF biochemist wins prestigious prize 3Viagra against heart failure: Researchers at the RUB and from Rochester throw light on the mechanism 2
(Date:1/23/2015)... Biofertilizers stimulate microbial activities in soil. These microorganisms generate ... activities in the soil or in the rhizosphere. The ... on reducing environmental pollution and on reducing the usage ... the bio fertilizers market with analysis and forecasting of ...
(Date:1/22/2015)... 22, 2015  Transwestern | RBJ today announces the firm brokered ... for Shire a leading biopharmaceutical company, at Two Ledgemont Center ... Robert Richards , president, and Brian Cohen , ... entire five-floor building at 95 Hayden Ave. Photo ...
(Date:1/22/2015)... Protocol Networks brings independent technology consulting ... brand-neutral, independent consultants, Protocol Networks has recently announced its ... the years, his company has attracted several clients in ... as well as others. With the success of these ...
(Date:1/22/2015)... 2015 Controlled Substance Compliance Services (CSCS), ... companies check the legal requirements around using controlled substances ... , As their international operations expand and become ... solutions built as a result of the first phase ...
Breaking Biology Technology:Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 2Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 3Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 4Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Global Compliance Service for Controlled Substances to Expand to China 2
... Inc. (Nasdaq:,INSM) CEO Geoffrey Allan issued the following statement ... Drug Administration statements on,developing an approval pathway for follow-on ... the White House recognizes the,importance of establishing a follow-on ... to Americans., "We are also pleased by news ...
... Calif., Feb. 5 BioSeek, Inc. today,announced that ... of the,Company,s board of directors. Mr. Whitfield had ... business advisor to the Company since November,2005., ... and,business development have been extraordinarily valuable to BioSeek ...
... 5 NeurogesX, Inc.,(Nasdaq: NGSX ), a biopharmaceutical ... announced today that,Anthony DiTonno, Chief Executive Officer, is scheduled ... the 10th Annual BIO CEO & Investor,Conference in New ... Event: 10th Annual BIO CEO & Investor Conference ...
Cached Biology Technology:Insmed CEO Issues Statement on White House FY09 Budget and FDA Statements on Follow-On Biologics 2BioSeek Elects Roy Whitfield Executive Chairman of Board of Directors 2NeurogesX to Present at the 10th Annual BIO CEO & Investor Conference 2NeurogesX to Present at the 10th Annual BIO CEO & Investor Conference 3
ABIN-2 Polyclonal Ab 100 ug rabbit polyclonal antibody. Detects ABIN-2 in human/mouse. Tested in WB....
... 100 slides. Immunocytochemistry.Sample types: suitable for ... labeling.Recommended cell number: 10 6-107 ... at 2-8 C (except DAB: -15 ... & Cellular Assays, Assays . Specific ...
CLIM-2 (T-16)...
... and affinity purification of small components ... monodisperse magnetic particles (2.8 m in ... surface activation is not required. Allows ... orientation for affinity purification of proteins. ...
Biology Products: