Navigation Links
Do our medicines boost pathogens?
Date:12/21/2011

Scientists of the Institute of Tropical Medicine (ITG) discovered a parasite that not only had developed resistance against a common medicine, but at the same time had become better in withstanding the human immune system. With some exaggeration: medical practice helped in developing a superbug. For it appears the battle against the drug also armed the bug better against its host. "To our knowledge it is the first time such a doubly armed organism appears in nature", says researcher Manu Vanaerschot, who obtained a PhD for his detective work at ITG and Antwerp University. "It certainly makes you think."

Vanaerschot studies the Leishmania parasite, a unicellular organism that has amazed scientists before. Leishmania is an expert in adaptation to different environments, and the only known organism in nature disregarding a basic rule of biology: that chromosomes ought to come in pairs. (The latter was also discovered by ITG-scientists recently.)

The parasite causes Leishmaniasis, one of the most important parasitic diseases after malaria. It hits some two million people, in 88 countries including European ones and yearly kills fifty thousand of them. The parasite is transmitted by the bite of a sand fly. The combined resistance against a medicine and the human immune system emerged in Leishmania donovani, the species causing the deadly form of the disease.

On the Indian subcontinent, where most cases occur, the disease was treated for decades with antimony compounds. As was to be expected, the parasite adapted to the constant drug pressure, and evolved into a form resisting the antimonials. In 2006 the treatment was switched to another medicine, because two patients out of three did not respond to the treatment. The antimonials closely work together with the human immune system to kill the parasite. This probably has given Leishmania donovani the opportunity to arm itself against both. It not only became resistant
'/>"/>

Contact: Jean-Claude Dujardin
jcdujardin@itg.be
32-324-76358
Institute of Tropical Medicine Antwerp
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. First study to reveal how paracetamol works could lead to less harmful pain relief medicines
2. Scripps Health/the Medicines Company announce late breaking BRIDGE trial results presented at TCT
3. Clinical tests for medicines made from genetically modified plants
4. Medicines from plants
5. Accelerated lab evolution of biomolecules could yield new generation of medicines
6. Sunlight can influence the breakdown of medicines in the body
7. New treaty on search for life-saving medicines in remote areas
8. 40-year-old test procedure finds modern niche in developing new medicines
9. Reducing gene-damaging impurities in medicines
10. Problem of fake medicines in developing countries could be solved
11. Insight into cells could lead to new approach to medicines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Do our medicines boost pathogens?
(Date:10/16/2014)... Researchers at William and Mary,s Virginia Institute of ... from the Environmental Protection Agency to identify the ... and to develop tools to help local governments ... project depends critically on a dataset of tidal-marsh ... 1970s. Only with this historical baseline can today,s ...
(Date:10/16/2014)... 16, 2014) – Post-menopausal women experienced improvements in ... levels or genital bleeding, after 12 weeks of ... fermented soy germ-based nutritional supplement previously shown to ... new peer-reviewed pilot study reported in a poster ... scientific meeting. , "These data documented improved ...
(Date:10/15/2014)... has admitted Johannes Gutenberg University Mainz (JGU) as ... hub continues to maintain a significant nationwide standing ... "The acceptance of Johannes Gutenberg University Mainz as ... milestone in the national and international competition for ... of Rhineland-Palatinate can be proud that Mainz University ...
Breaking Biology News(10 mins):EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... from the p53 Laboratory of Singapore,s Agency for Science, Technology ... a unique method of cancer treatment. Their work, published online ... today , offers new insight on how to tap on ... to more effectively kill cancer cells while sparing normal cells. ...
... Scientists have caught male topi antelopes in the act of faking ... improve their chances of having sex. The male antelopes, observed ... nearby only when females in heat are in their territories. When ... long enough for some males to fit in a quick mating ...
... May 24 BIO-key International, Inc. (OTC Bulletin Board: BKYI), ... has integrated BIO-key,s biometric software into its Enterprise Single Sign-on (SSO) ... two major pharmaceutical companies. , ... (Logo: http://www.newscom.com/cgi-bin/prnh/20050509/BIOKEYLOGO ) , ...
Cached Biology News:Singapore scientists exploit knowledge of p53 for increasing specificity of cancer treatments 2Male antelopes trick females into extra sex opportunities 2Male antelopes trick females into extra sex opportunities 3BIO-key(R) Biometric Identification Now Incorporated Into Evidian Enterprise Single Sign-On Solution 2BIO-key(R) Biometric Identification Now Incorporated Into Evidian Enterprise Single Sign-On Solution 3BIO-key(R) Biometric Identification Now Incorporated Into Evidian Enterprise Single Sign-On Solution 4
(Date:10/20/2014)... Local veterinary surgeon, Dr. Tim McCarthy ... of donor stem cells for dogs with osteoarthritis. Dr. ... has performed clinical stem cell therapy for 7 years. ... if a single injection of donor stem cells into ... pain and inflammation in the treated joints. , ...
(Date:10/19/2014)... CAMBRIDGE, Mass. , Oct. 19, 2014 NextCODE ... of the whole genome in real time, today announced the ... the NextCODE Exchange , at the American Society of ... . To learn more, sign up and apply for ... on its unique features and benefits can be viewed ...
(Date:10/19/2014)... Asia-Pacific Speech Analytics market report defines and segments the ... of revenue. This market is estimated to grow from ... at a Compound Annual Growth Rate (CAGR) of 23.9% ... of the Asia-Pacific Speech Analytics market report to get ... provides a glimpse of the segmentation in the market, ...
(Date:10/19/2014)... The report "Unmanned Ground Vehicle Market ... Payload, Type & by Geography - Forecasts & ... ground vehicle market into various sub segments with ... The report also identifies the factors driving this ... with the adoption trends. , The unmanned ground ...
Breaking Biology Technology:Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5
... , , , Multiporator / Electroporator 2510 , , , , , ... Transformation Protocol , Protocol No. 4308 915.532 01/2002 , ... , , , ... , Cell type , Bacteria, gram negative, ...
... , , , Multiporator / Electroporator 2510 , , , , , ... Transformation Protocol , Protocol No. 4308 915.529 01/2002 , ... , , , ... , Cell type , Bacteria, gram negative, ...
... , Multiporator / Electroporator 2510 , , , , , , ... , Protocol No. 4308 915.540 07/2002 , , ... , , Microorganism , ... Cell type , Bacteria, gram positive, , ...
Cached Biology Technology:Salmonella typhimurium 2Pseudomonas putida 2Pediococcus spp. 2
Caspase Activity Detector, SR-VAD-FMK Kit , 100 tests Consult technical datasheet for details....
Auto/Zyme Reagent...
Interact with both DNA and RNA; fluorescence green (Em=525 nm) bound to DNA; and fluorescence red (Em=~650 nm) bound to RNA....
...
Biology Products: