Navigation Links
Do men's and women's hearts burn fuel differently?
Date:5/21/2013

Researchers at the University of Illinois at Chicago College of Medicine will study gender differences in how the heart uses and stores fat -- its main energy source -- and how changes in fat metabolism play a role in heart disease, under a new $2 million, 4-year grant from the National Heart, Lung and Blood Institute.

When stressed, the heart changes how it uses fuel for energy. These changes may play a major role in the development of heart disease and are different in men and women, says E. Douglas Lewandowski, director of the UIC Center for Cardiovascular Research. The changes occur long before any symptoms, he said, and may be key to early diagnosis and treatment.

Lewandowski, who is principal investigator on the grant, uses imaging techniques he developed to see fat molecules and the rate at which they are being burned in beating hearts. In healthy hearts, the balance between using fat for energy and storing it in tiny droplets within the cells is in a dynamic equilibrium.

When a female heart is stressed, such as through chronic disease like hypertension, it becomes much less efficient at metabolizing fat, Lewandowski says. When a male heart is stressed, it starts using more sugar as fuel. These changes in the heart can also affect how fat is stored and used in other parts of the body.

"Because the heart is the body's number-one consumer of fat, when it starts using fat differently, there are consequences throughout the entire body," Lewandowski said. He thinks that changes in fat metabolism in the heart may send out signals to fat cells in other parts of the body to store more fat, and to insulin-producing cells in the pancreas that may trigger the onset of diabetes, which is often present along with heart disease.

Lewandowski will further investigate how gender differences in fat metabolism are related to the development of heart disease in men and women. He will also look at how higher levels of fat accumulation in heart cells may cause stiffness and lower the efficiency of heart muscle contraction. Understanding these changes may help identify targets for therapies, or lead to better diagnostic tests for heart disease.

Lewandowski also received a prestigious MERIT Award from the National Institutes of Health for his pioneering work in developing the imaging technique he uses to measure metabolic rates in intact, functioning organs in the body.


'/>"/>

Contact: Sharon Parmet
sparmet@uic.edu
312-413-2695
University of Illinois at Chicago
Source:Eurekalert

Related biology news :

1. Women altering menstruation cycles in large numbers, UO study shows
2. Age at first menstrual cycle, menopause tied to heart disease risk
3. New optical tweezers trap specimens just a few nanometers across
4. TGen method isolates biospecimens for treatment of kidney disease
5. Scientists discover new trigger for immense North Atlantic plankton bloom
6. Brothers in arms: Commensal bacteria help fight viruses
7. High-resolution atomic imaging of specimens in liquid by TEM using graphene liquid cell
8. A new dimension for solar energy
9. Nanomaterials key to developing stronger artificial hearts
10. RUB researchers find over active enzyme in failing hearts
11. Gene therapy reprograms scar tissue in damaged hearts into healthy heart muscle
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/27/2016)... , Jan. 27, 2016  Rite Track, Inc. ... in West Chester, Ohio announced ... winning service staff, based in Austin, Texas ... and ability to provide modifications, installations and technical support ... , CEO of PLUS, commented, "PLUS has provided world ...
(Date:1/21/2016)... PUNE, India , January 21, 2016 /PRNewswire/ ... According to a new market research report "Emotion ... Learning, and Others), Software Tools (Facial Expression, Voice ... and Regions - Global forecast to 2020", published ... Market is expected to reach USD 22.65 Billion ...
(Date:1/15/2016)... , Jan. 15, 2016 Recent publicized ... small to find new ways to ensure data security ... iOS and Android that ties ... biometrics, transforming it into a hardware authorization token. Customer ... swipe their fingerprint on their KodeKey enabled device to ...
Breaking Biology News(10 mins):
(Date:2/5/2016)... DIEGO , Feb. 5, 2016 On ... region,s trusted information source for community, health and disaster ... Diego) will integrate to enhance care coordination and ... to the services they need and to better connect ... improve care.   San Diego ...
(Date:2/4/2016)... ... 04, 2016 , ... Morf Media Inc ., shaping ... FDA compliance training course, Writing Effective SOPs (Standard Operating ... course on Morf Playbook—now conveniently available on smartphones and PCs--provides step by step ...
(Date:2/4/2016)... ... , ... Shimadzu Scientific Instruments will showcase several new products, ... sessions, and present on the analysis of mycotoxins and medical cannabis at the ... at the Georgia World Congress Center in Atlanta, Georgia. , Attendees should ...
(Date:2/4/2016)... Feb. 4, 2016  CytoSorbents Corporation (NASDAQ: ... its flagship CytoSorb® blood filter to treat deadly ... the world, announced that CEO Dr. Phillip ... Source Capital Group,s 2016 Disruptive Growth & Healthcare ... company.  Conference Presentation Details: ...
Breaking Biology Technology: