Navigation Links
Do-it-yourself viruses: How viruses self assemble
Date:12/16/2012

A new model of the how the protein coat (capsid) of viruses assembles, published in BioMed Central's open access journal BMC Biophysics, shows that the construction of intermediate structures prior to final capsid production (hierarchical assembly) can be more efficient than constructing the capsid protein by protein (direct assembly). The capsid enveloping a virus is essential for protection and propagation of the viral genome. Many viruses have evolved a self-assembly method which is so successful that the viral capsid can self assemble even when removed from its host cell.

The construction of large protein structures has been observed experimentally but the mechanism behind this is not well understood. Even the 'simple' icosahedral protein coat of the T1 virus requires integration of 60 protein components. Computational models of the physical interactions of component proteins are used to investigate the dynamics and physical constraints that regulate whether the components assemble correctly.

Using computer simulations a team from the Institute for Theoretical Physics and the Center for Quantitative Biology (BioQuant), University of Heidelberg, has compared direct and hierarchical assembly methods for T1 and T3 viruses. The team led by Ulrich S Schwarz, realised that direct assembly often led to the formation of unfavorable intermediates, especially when the dissociation rate was low, which hindered further assembly, causing the process to stall. In contrast, for many conditions hierarchical assembly was more reliable, especially if the bonds involved had a low dissociation rate.

Discussing the practical applications of these results, Dr Schwarz commented, "Hierarchical assembly has not been systematically investigated before. Theoretical models and computer simulations, like ours, can be used to understand the mechanism behind assembly of complex viruses and give an indication of how other large protein complexes assemble."

He continued, " With our computer simulations, we are now in a position to investigate systems which are too large to be studied by molecular resolution. This rational approach might have many applications not only in biomedicine, but also in materials science, where many researchers strive to learn from nature how to assembly complex structures."


'/>"/>

Contact: Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert  

Related biology news :

1. Scripps Research Institute scientists describe elusive replication machinery of flu viruses
2. New coronavirus related to viruses from bats
3. £12 million funding to tackle devastating livestock and poultry viruses
4. How and why herpes viruses reactivate to cause disease
5. Viruses not to blame for chronic fatigue syndrome after all
6. Study of giant viruses shakes up tree of life
7. Viruses could be the key to healthy corals
8. Computer viruses could take a lesson from showy peacocks
9. Viruses with integrated gene switch
10. MBL scientists to explore hidden realm of microbes, viruses beneath the ocean floor
11. Viruses linked to algae that control coral health
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Do-it-yourself viruses: How viruses self assemble
(Date:5/16/2017)...   Bridge Patient Portal , an enterprise ... EMR Systems , an electronic medical record solutions ... established a partnership to build an interface between ... Centricity™ products, including Centricity Practice Solution (CPS), Centricity ... new integrations will allow healthcare delivery networks using ...
(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
(Date:4/13/2017)... UBM,s Advanced Design and Manufacturing event in ... and evolving technology through its 3D Printing and Smart ... the expo portion of the event and feature a ... on trending topics within 3D printing and smart manufacturing. ... will take place June 13-15, 2017 at the Jacob K. ...
Breaking Biology News(10 mins):
(Date:6/23/2017)... UK (PRWEB) , ... June 23, 2017 , ... Ken ... Lula, president of Physik Instrumente USA, have been selected as this year’s recipients of ... , The two have been invited along with other honorees to accept their awards ...
(Date:6/22/2017)... ... June 21, 2017 , ... RMC Pharmaceutical Solutions, ... engages Timothy Reinhardt to manage the new site. , Tim has 25 years ... his most recent role as the Director of Manufacturing and Supplier Quality Assessment. ...
(Date:6/22/2017)... ... June 22, 2017 , ... For ... has produced a Spotlight series on “Cell Therapy Regulation” for ... by leading experts on the unique regulatory challenges of stem cell medical research. ...
(Date:6/22/2017)... ... June 22, 2017 , ... Charm Sciences, Inc. is pleased to ... was determined to be appropriate as a screening test at dairies and farms for ... EZ system, and the Charm EZ Lite system. These systems are a combination incubator ...
Breaking Biology Technology: