Navigation Links
Do-it-yourself viruses: How viruses self assemble
Date:12/16/2012

A new model of the how the protein coat (capsid) of viruses assembles, published in BioMed Central's open access journal BMC Biophysics, shows that the construction of intermediate structures prior to final capsid production (hierarchical assembly) can be more efficient than constructing the capsid protein by protein (direct assembly). The capsid enveloping a virus is essential for protection and propagation of the viral genome. Many viruses have evolved a self-assembly method which is so successful that the viral capsid can self assemble even when removed from its host cell.

The construction of large protein structures has been observed experimentally but the mechanism behind this is not well understood. Even the 'simple' icosahedral protein coat of the T1 virus requires integration of 60 protein components. Computational models of the physical interactions of component proteins are used to investigate the dynamics and physical constraints that regulate whether the components assemble correctly.

Using computer simulations a team from the Institute for Theoretical Physics and the Center for Quantitative Biology (BioQuant), University of Heidelberg, has compared direct and hierarchical assembly methods for T1 and T3 viruses. The team led by Ulrich S Schwarz, realised that direct assembly often led to the formation of unfavorable intermediates, especially when the dissociation rate was low, which hindered further assembly, causing the process to stall. In contrast, for many conditions hierarchical assembly was more reliable, especially if the bonds involved had a low dissociation rate.

Discussing the practical applications of these results, Dr Schwarz commented, "Hierarchical assembly has not been systematically investigated before. Theoretical models and computer simulations, like ours, can be used to understand the mechanism behind assembly of complex viruses and give an indication of how other large protein complexes assemble."

He continued, " With our computer simulations, we are now in a position to investigate systems which are too large to be studied by molecular resolution. This rational approach might have many applications not only in biomedicine, but also in materials science, where many researchers strive to learn from nature how to assembly complex structures."


'/>"/>

Contact: Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert  

Related biology news :

1. Scripps Research Institute scientists describe elusive replication machinery of flu viruses
2. New coronavirus related to viruses from bats
3. £12 million funding to tackle devastating livestock and poultry viruses
4. How and why herpes viruses reactivate to cause disease
5. Viruses not to blame for chronic fatigue syndrome after all
6. Study of giant viruses shakes up tree of life
7. Viruses could be the key to healthy corals
8. Computer viruses could take a lesson from showy peacocks
9. Viruses with integrated gene switch
10. MBL scientists to explore hidden realm of microbes, viruses beneath the ocean floor
11. Viruses linked to algae that control coral health
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Do-it-yourself viruses: How viruses self assemble
(Date:2/8/2017)... 7, 2017 The biometrics market has ... confluence of organizations, desires to better authenticate or ... (password and challenge questions), biometrics is quickly working ... The market is driven by use cases, though ... and enterprise uses cases, with consumer-facing use cases ...
(Date:2/7/2017)... New York , February 7, 2017 ... as ID Global Solutions Corporation [OTC: IDGS], ("Ipsidy" or ... management and electronic transaction processing services, is pleased to ... of the Company. Effective January 31, 2017, ... the Board of Directors, CEO and President.  An experienced ...
(Date:2/2/2017)... , Feb. 2, 2017   TapImmune, Inc. ... immuno-oncology company specializing in the development of innovative ... treatment of cancer and metastatic disease, announced today ... GMP manufacturing of a second clinical lot of ... folate receptor alpha. The manufactured vaccine product will ...
Breaking Biology News(10 mins):
(Date:3/1/2017)... ... March 01, 2017 , ... ... will demonstrate how concentrating on protection, productivity and quality can help food and ... range of solutions – from x-ray and checkweighing to vision inspection and metal ...
(Date:3/1/2017)... 2017  Elizabeth Young and Joshua Rosenthal , ... Washington University,s Health Workforce Speaker series. http://bit.ly/2lA6C8B ... will be speaking on March 9, 2017 at the ... Washington, DC at 12:00pm. The ... renowned speakers to examine new workforce configurations, their outcomes ...
(Date:2/28/2017)... Diego, California (PRWEB) , ... ... ... Inc., the supplier of 3D nano-porous silicon biosensors and instruments for sensitive, ... and St. Marianna University, School of Medicine in Japan. The collaborators expect ...
(Date:2/28/2017)... , Feb. 28, 2017  Phosphorus, a ... today the formation of the Phosphorus Scientific Advisory ... experts chosen to advise the company on the ... multi-site research initiatives. Please visit http://phosphorus.com/about-us/ ... initiatives. "We,ve gathered some of the ...
Breaking Biology Technology: