Navigation Links
Do eggs matured in the laboratory result in babies with Large Offspring syndrome?
Date:6/30/2010

s, vacuum extractions and forceps deliveries compared to IVF/ICSI births and births after natural conception.

"These findings suggest a significant impact of the IVM procedure on early development," said Dr Sjblom. "The pattern of increased birth weight, more obstetric interventions and possibly a longer gestation period are consistent with Large Offspring Syndrome. It cannot be explained by there being a higher proportion of women with polycystic ovarian syndrome in the IVM group*, since the birth weight of their offspring was not significantly different from babies born after natural conception.

"We urge IVM practitioners and clinics to pool their data on obstetric and neonatal outcomes after fertility treatments because, at present, only limited data on small numbers of births are available. This should enable us to look more closely at the health and physiology of babies born after fertility treatment so that we can make a more detailed assessment of infant health. If the observed pattern still holds as the number of observations increases, then in-depth studies of mechanisms must be initiated. Caution is called for before proceeding with IVM on a large scale."

He said the possible mechanisms involved were unclear. "It has been described in the literature that gene expression is altered in IVM eggs compared to those matured naturally in the body; it may be the case that the final stages of egg development before ovulation involves events that are crucial to development and that this is not happening when they are matured in the lab. Another explanation could be that the preparation of the lining of the womb (the endometrium) is different and this may influence development, as has been shown in animal studies."

The long-term consequences to the health of babies born after IVM are also unknown. "For the sake of the health and safety of the babies and their mothers, we need to be following IVM babies from the moment the eggs
'/>"/>

Contact: Emma Mason
wordmason@mac.com
European Society of Human Reproduction and Embryology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UMCES Horn Point Laboratory scientists to study oil spill effects in Gulf of Mexico
2. Story tips from the US Department of Energys Oak Ridge National Laboratory -- June 2010
3. Ames Laboratory scientists win national technology transfer awards
4. Story tips from the US Department of Energys Oak Ridge National Laboratory April 2010
5. ModiFace Launches iLab: An iPhone and iPad App Experimentation Laboratory
6. Story tips from the US Department of Energy’s Oak Ridge National Laboratory February 2010
7. AMP releases statement on oversight of laboratory tests
8. GenWay Clinical Laboratory receives accreditation from College of American Pathologists
9. New source of classical techniques for blood-based studies in the laboratory mouse
10. NSF authorizes $29 million for preliminary design of worlds deepest underground laboratory
11. NY Gov. Paterson renews commitment to stem cell research in visit to Cold Spring Harbor Laboratory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... 2014 Psychological stress and stress-related psychiatric disorders are ... but the molecular mechanisms underlying this relation ... to the development of targeted preventive strategies ... devastating diseases. This work is presented at ... Berlin., Now an international group of researchers ...
(Date:10/17/2014)... shown for the first time how bacteria can grow ... them the opportunity to get tremendous insights into bacteria ... also discovered the bacterial growth in chronic lung infections ... down by the immune cells. The researchers discovered the ... the bacteria, forcing the bacteria to switch to a ...
(Date:10/16/2014)... the bowel lining develops and, in the process, suggested ... The researchers produced evidence that stem cells are responsible ... feature of the bowel lining, and believe these stem ... finding as scientists are still divided on the stem ... Wee Tan and Professor Tony Burgess from the Walter ...
Breaking Biology News(10 mins):Researchers find why depression and aging linked to increased disease risk 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2Cryptic clues drive new theory of bowel cancer development 2
... CORVALLIS, Ore. Fungi have significant potential for "horizontal" ... mechanisms that allow bacteria to evolve so quickly, become resistant ... to be published Thursday in the journal Nature , ... make-up of their genomes and become infectious to plants and ...
... like a mashup of monster movies, but palaeontologists have discovered ... a killing that took place 4 million years ago. ... by careful, forensic-style analysis of bite marks on an otherwise ... have reconstructed the events that led to the death of ...
... scientists have successfully used geometrically patterned surfaces to influence ... a departure from that of many stem-cell biologists, who ... controlling the fate of stem cells. "The cells ... it,s the shape alone that,s dictating whether they turn ...
Cached Biology News:Fungi can change quickly, pass along infectious ability 2Jaws -- 4 million B.C. 2
(Date:10/22/2014)... 2014 WriteResult, LLC – a ... been working with a team of researchers from Yale ... Community Farming Collaborative to provide electronic questionnaire data collection ... study, which started in May, aims to evaluate the ... weekly exposure to and participation in urban agriculture to ...
(Date:10/22/2014)... Rock Hill, SC (PRWEB) October 22, 2014 ... the expansion of its cardiovascular pharmacogenetics menu, which ... improved patient outcomes. With PCLS’s evidence-based results, ... individual needs and optimize their therapy, while minimizing ... , In the U.S., according to the FDA ...
(Date:10/22/2014)... , Oct. 22, 2014 /PRNewswire/ - iCo Therapeutics ("iCo" ... announced next steps for its Oral Amphotericin B ... its in vitro work involving samples ... now plans to complete pre clinical studies and ... Phase 1A clinical trial, utilizing approximately $700,000 of ...
(Date:10/22/2014)... and HONG KONG , Oct. 22, ... therapeutics enterprise, announced today that rare disease expert ... vice president, research. Dr. McKew brings more than two ... positions at the National Institutes of Health, Wyeth Research ... Wyeth). Dr. McKew will lead aTyr,s efforts to expand and ...
Breaking Biology Technology:myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3
... York are pioneering the development of electron microscopes which ... materials in new revolutionary ways., The team, headed by ... University,s Department of Physics has created electron beams with ... will open the way to many novel applications including ...
... Inc. announced today the publication of key results relating ... discovery for high-value G-protein-coupled receptor (GPCR) targets in ... of a Lipid G Protein-Coupled Receptor," was co-authored by ... Ph.D., and Raymond Stevens, Ph.D. Drs. Rosen and Stevens ...
... Pa., Feb. 16, 2012  BioDelivery Sciences International, Inc. (Nasdaq: ... Trademark Office (USPTO) has issued a Notice of Allowance ... granted, will extend the exclusivity of the BioErodible MucoAdhesive ... Buprenorphine/Naloxone from 2020 to 2027.  A ...
Cached Biology Technology:York researchers create 'tornados' inside electron microscopes 2Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science 2Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science 3Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science 4BioDelivery Sciences Receives Patent Allowance Triggering $15 Million Milestone Payment from Endo Pharmaceuticals 2BioDelivery Sciences Receives Patent Allowance Triggering $15 Million Milestone Payment from Endo Pharmaceuticals 3BioDelivery Sciences Receives Patent Allowance Triggering $15 Million Milestone Payment from Endo Pharmaceuticals 4BioDelivery Sciences Receives Patent Allowance Triggering $15 Million Milestone Payment from Endo Pharmaceuticals 5