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Do anaesthetics trigger stress?
Date:9/24/2013

n science around the world, it is very important that the anaesthetics used to do this are the most humane available and do not themselves cause a stress response. "

The team found that several commonly used anaesthetics were aversive, including two of the most commonly recommended and used: MS222 (ethyl 3-aminobenzoate methanesulphate) and benzocaine. For ethical best practice, it is recommended that compounds that are aversive, even at low concentration, should no longer be used routinely for anaesthesia or for the first step of humane euthanasia of adult zebrafish.

Two agents were found not to induce aversive behavioural responses: etomidate and 2,2,2 tribromoethanol.

For the millions of adult zebrafish used in laboratories and breeding worldwide, the research team found the anaesthetic etomidate appears best suited for future routine humane use.

There have been advancements in general veterinary anaesthesia for mammals, but fish have been left behind and the research team hope this work will begin to re-address that balance.


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Contact: Joanne Fryer
joanne.fryer@bristol.ac.uk
44-011-733-17276
University of Bristol
Source:Eurekalert

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