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Do 68 molecules hold the key to understanding disease?
Date:9/4/2008

"We have now found instances where the pathogenesis of widespread and chronic diseases can be attributed to a change in the glycome, for example, in the absence of definable changes in the genome or proteome," Marth said, adding that, as biomedical researchers, "we need to begin to cultivate the integration of disciplines in a holistic and rigorous way in order to perceive and most effectively manipulate the biological mechanisms of health and disease."

"What is important is that no one has composed it and laid it out so clearly before," said Ajit Varki, M.D., Distinguished Professor of Medicine and Cellular and Molecular Medicine and founder and co-director of the Glycobiology Research and Training Center at UC San Diego School of Medicine, and chief editor of the major textbook in the field, The Essentials of Glycobiology. "Glycobiology, for example, is a relatively new field of study in which researchers at UC San Diego have much expertise, and Dr. Marth's work further illustrates the importance of these glycan molecules."

Marth believes that biology should become more integrative both in academic and research settings. "I'm one who believes that we don't need to sacrifice breadth of knowledge in order to acquire depth of understanding."


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Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

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