Navigation Links
'Diving board' sensors key to DNA detection
Date:7/27/2012

tiate the "springboard" effect by applying an electric current. This is an upgrade over the classical cantilever method which requires an external stimulus a flick of the diving board to set the system into motion.

Because PZT sensors are completely controllable, Mutharasan's group has discovered high-order vibration modes in certain designs that are sensitive to very small mass changes, on the order of one-billionth of a microgram, in liquid samples.

"Such high sensitivity enables us to measure biological molecules at a million-fold more sensitive than what is currently feasible," Mutharasan said

A Second Advantage: Rapid Room-Temperature Replication of DNA

The PZT cantilever device is dually useful because it speeds up the process of replicating DNA in a sample. Replication is a necessary step in the testing process in order to improve the quality of the sample and positively identify the bacteria or cell of its origin, much like growing bacterial culture. Muthrasan's research group will conduct simultaneous amplification and detection of DNA that is expected to be carried out at room temperature and in a short time frame.

Typical replication can be time-consuming because the sample needs to be heated in order to begin the process. The advantage of the cantilever sensor is that double-stranded DNA can be unwound by vibrating the sensor at the proper frequency. This procedure essential step for replication can cut a typical detection process, which could take several hours, down to less than an hour.

The National Science Foundation recently awarded the team a grant to continue research into simultaneous DNA replication and detection using these piezoelectric vibrations. The key discovery that Mutharasan's team is building upon is its observation that DNA can be "melted" a term describing the process of unwinding a DNA strand for replication by application of mechanical energy to sensor surface via PZ
'/>"/>

Contact: Britt Faulstick
bef29@drexel.edu
215-895-2617
Drexel University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Elephant seal tracking reveals hidden lives of deep-diving animals
2. Ken Bierly of the Oregon Watershed Enhancement Board to receive ESA Regional Policy Award
3. FirstMark Scientific Board of Advisors Meet to Discuss New Clinical Studies for PREvent
4. BiOptix announces expansion of Board of Directors
5. FirstMark Welcomes Renowned Cardiologist and Researcher Dr. Prediman K. Shah to Scientific Advisory Board
6. FirstMark Welcomes Renowned Cardiologist and Researcher Dr. Prediman K. Shah to Scientific Advisor Board
7. AnaptysBio Adds Dr. David L. Lacey and Dr. Michael Gallatin to Therapeutic Advisory Board
8. Motion sensors detect horse lameness earlier than veterinarians, MU study finds
9. Miniature Sandia sensors may advance climate studies
10. Tiny electrical sensors could signal faster MRSA diagnosis
11. Miniature pressure sensors for medical touch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... A species of gut bacteria called Clostridium ramosum , ... weight. The work is published this week in mBio ... Microbiology. , A research team from the German Institute ... human gut bacteria including C. ramosum gained weight ... C. ramosum were less obese even when consuming ...
(Date:9/29/2014)... Monday, September 29: Between 1970 and 2010 populations ... the globe dropped 52 percent, says the 2014 ... Fund (WWF). This biodiversity loss occurs disproportionately in ... of high-income countries. , In addition to the ... point to other warning signs about the overall ...
(Date:9/29/2014)... should use ventilation when cooking with a gas stove, ... new study showed an association between gas kitchen stove ... "In homes where a gas stove was used without ... than in homes where a gas stove was used ... the College of Public Health and Human Sciences at ...
Breaking Biology News(10 mins):Gut bacteria promote obesity in mice 2Half of global wildlife lost, says new WWF report 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 3
... from the Asian continent, Drosophila suzukii has only been ... into the Iberian Peninsula, it accelerated towards the north of Europe ... are cherries and red fruits but any type of fruit is ... a threat to the fruit of more and more European countries. ...
... 2012)A rapid increase in shipping in the formerly ice-choked ... risk to the region,s marine mammals and the local ... cultural identity, according to an Alaska Native groups and ... workshop. , The workshopwhich ran from March 12-14examined ...
... Naval Research (ONR) will bring its technologically advanced fuel ... Pacific Operational Science & Technology (S&T) Conference in Honolulu, ... strategic area for the Navy and Marine Corps," said ... worldwide leaders in S&T at this event to discuss ...
Cached Biology News:An invasive Asian fly is taking over European fruit 2Increase in Arctic shipping poses risk to marine mammals 2Increase in Arctic shipping poses risk to marine mammals 3Increase in Arctic shipping poses risk to marine mammals 4ONR outreach focuses on Pacific total force 2
(Date:10/1/2014)... 2014 METTLER TOLEDO’s newly improved XS ... balances as well as a dual range ... the new SmartPan™ weighing pan delivers results up to ... all balances, ergonomic design details mean users no longer ... for long periods in front of the balance. Barbara ...
(Date:10/1/2014)...  Spherix Incorporated (Nasdaq: SPEX) -- an intellectual property development ... intellectual property, announced today that the Markman hearing ... the U.S. District Court for the Northern District ... rescheduled for November 10, 2014.  This hearing was ... Order setting the Markman date was received after ...
(Date:10/1/2014)... Today the National Institutes of ... for the Brain Research through Advancing Innovative Neurotechnologies ... and revolutionize new methods of understanding the complexities ... This first round of grants totaling $46 million ... to more than 100 investigators in 15 states ...
(Date:10/1/2014)... 2014 Slone Partners , a ... IT, and Laboratory Testing industries, reported a 120% increase ... director level and above from July 2013 to July ... top of rapid breakthroughs in diagnostics, reimbursement has failed ... have been forced to fold, consolidate, or carry on ...
Breaking Biology Technology:METTLER TOLEDO’s XS Balance Line Delivers Performance and Ergonomics To Safeguard Health in the Workplace 2METTLER TOLEDO’s XS Balance Line Delivers Performance and Ergonomics To Safeguard Health in the Workplace 3Markman Hearing Date for VTech and Uniden Litigation Now Set for November 10, 2014 2NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 2NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 3Slone Partners Meets Growing Demand as Industry Focuses on Reimbursement & Regulation 2
... Nov. 28 Life scientists are highly,engaged users ... preliminary,results of a worldwide study of more than ... provider of market research services. The,survey, co-sponsored by ... business-to business advertising and marketing,agency, found that 77 ...
... antibody,engineering company developing novel antibodies and antibody fragments,based on ... raised EUR 3.0 million from Novo A/S in a ... by Aescap Venture and Atlas Venture.,After this Second Closing, ... EUR 9.0 million. In total, the Company has raised ...
... testing demonstrate ANAVEX 1-41 has significant ... neuroprotective and anti-amnesic benefits, GENEVA, Nov. ... is pleased to announce promising developments with,ANAVEX 1-41, the ... animal studies, ANAVEX 1-41 prevented oxidative stress,which damages and ...
Cached Biology Technology:Scientists Using Social Media to Inform Lab Purchasing Decisions 2Antibody Engineering Company f-star Raises EUR 3.0 Million in a Second Closing of its Series A Financing Round From Novo A/S 2Antibody Engineering Company f-star Raises EUR 3.0 Million in a Second Closing of its Series A Financing Round From Novo A/S 3Anavex advances drug candidate for treatment of Alzheimer's disease 2Anavex advances drug candidate for treatment of Alzheimer's disease 3Anavex advances drug candidate for treatment of Alzheimer's disease 4Anavex advances drug candidate for treatment of Alzheimer's disease 5
Unit Definition: 1 U corresponds to the amount of enzyme which produces 1 mol protons per minute at pH 5.5 and 30C (peptin from citrus peel, Fluka-No. 76280, as substrate)...
ANTI STENOTROPHOMONAS MALTOPHILIA...
... Features Convenient platform for tube handling ... 96 x 0.2ml V-bottom tubes - ... Plates - Thermo-Fast® 96 Non-Skirted Plate ... - 48 x 0.5ml Thermo-Tubes Multiple workstations ...
... 96 well Magnetic-Ring Stand is designed for ... U-bottom microplates. The stand has a plastic ... microtiter plate footprint. The use of 96 ... and easy magnetic separation. With this magnetic ...
Biology Products: