Navigation Links
Disulfiram: New support for an old addiction drug
Date:1/31/2013

Philadelphia, PA, January 31, 2013 Disulfiram was the first medication approved for the treatment of alcoholism over 50 years ago. It works, at least in part, by preventing the metabolism of an alcohol by-product, acetaldehyde. High levels of acetaldehyde in the body quickly cause unpleasant symptoms, including nausea, vomiting, headache, and accelerated heart rate. Thus, disulfiram provides a very strong incentive to avoid drinking.

Beginning in the late 1990s, a series of studies conducted at Yale University found that disulfiram reduced the consumption of cocaine, particularly in the context of alcohol or opiate dependence. One mechanism introduced to explain this phenomenon was the ability of disulfiram to inhibit dopamine β-hydroxylase, or DβH, an enzyme that converts dopamine to norepinephrine. This hypothesis was supported in a new pharmacogenetic study by Thomas Kosten and colleagues, published in Biological Psychiatry.

The researchers recruited cocaine- and opioid-dependent patients who were randomized to receive either disulfiram or placebo for ten weeks. They also genotyped the DBH gene, which alters DβH levels, to determine which variant that each patient carried. Prior work has already shown that individuals with the CC genotype have normal DβH levels, whereas those carrying the T allele have lower DβH levels. This allowed them to determine whether the functional DBH variant influences the success of disulfiram treatment.

Disulfiram was effective in reducing cocaine use in patients with the CC genotype and normal DβH levels, whereas those with the low DβH level T genotype showed no disulfiram effect. These data support the hypothesis that disulfiram reduces drug consumption, in part, by blocking DβH.

Senior author David Nielsen at Baylor College of Medicine said, "We found significantly greater efficacy in cocaine addicts who carried a genetic variant of the dopami
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. £35 million to support research for vital industrial sector
2. NSF Supports GlobalNSF supports global research to advance science and engineering for sustainability
3. 3-D biomimetic scaffolds support regeneration of complex tissues from stem cells
4. WHOI research projects awarded $5.2 million to support marine microbial research
5. Scale-up of a temporary bioartificial liver support system described in BioResearch Open Access
6. Can algae-derived oils support large-scale, low-cost biofuels production?
7. Combining two genome analysis approaches supports immune system contribution to autism
8. Cargill expands support of Notre Dame Haiti Program
9. BONESUPPORT für 2012 Top 100 Global Award von Red Herring ausgewählt
10. BONESUPPORT sélectionné en tant que 100 meilleures entreprises mondiales du Red Herring 2012
11. BONESUPPORT Selected As A 2012 Red Herring Top 100 Global
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... virus is spreading rapidly and to an unexpected extent. ... the past and the virus shows a new disease ... before. For this reason, the German National Academy of ... and Engineering, and the Union of the German Academies ... the Ebola epidemic today. , In the statement the ...
(Date:10/15/2014)...   Neurotechnology , a provider of high-precision ... the VeriLook Surveillance 3.0 software development kit ... face identification using live video streams from single ... version not only identifies faces in a crowd, ... they are moving through the video frame. It ...
(Date:10/14/2014)... – Scientists have sequenced the house fly genome for ... might expect from an insect that thrives in pathogen-rich ... Oct. 14 in the journal Genome Biology , ... and of how flies quickly adapt to resist insecticides, ... house flies (Musca domestica) carry and transmit more than ...
Breaking Biology News(10 mins):Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3House fly genome reveals expanded immune system 2
... indicated that the effects of prion disease could be ... their findings support developing early treatments that aim to ... people with prion disease. Also, they said that their ... new way: by analyzing their cognitive effects in prion-infected ...
... is resistant to cancer have begun to pin down how ... these mice overwhelm normal defenses of cancer cells. , In ... of Cancer Immunology, posted on line today, Zheng Cui, M.D., ... School of Medicine and colleagues said that several types of ...
... New autopsy data provide the strongest evidence yet that sudden ... has a concrete biological basis. In the November 1 issue ... the brainstem ?a part of the brain that regulates breathing, ... from SIDS. , SIDS is the leading cause of ...
Cached Biology News:Prion disease treatable if caught early 2White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells 2A potential biological cause for sudden infant death syndrome 2A potential biological cause for sudden infant death syndrome 3
(Date:10/20/2014)... ON , Oct. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: ... $1.7 million which brings Q3 orders to $5.8 million and provides ... control projects in North America and one ... continue to bid new projects at record levels," said Peter ... were higher at the end of Q3 than they have been ...
(Date:10/20/2014)... N.J. (PRWEB) October 20, 2014 ... the Sidney Kimmel Cancer Center at Thomas Jefferson ... , Through the Strategic Alliance Partnership program, ... OncLive will collaborate to raise awareness of the ... treatment, and other projects. Clinicians and other health ...
(Date:10/19/2014)... OCTOBER 20-22, 2014: The ... ABIM will take place at the Congress ... 2014 is now available at http://www.abim.ch ... and organizations from all over the globe ... the latest products and developments on the ...
(Date:10/19/2014)... 2014 The Asia-Pacific Speech Analytics market ... Asia-Pacific with analysis and forecast of revenue. This market ... to $208 million by 2019, at a Compound Annual ... , Browse through the TOC of the Asia-Pacific Speech ... in-depth analysis provided. It also provides a glimpse of ...
Breaking Biology Technology:Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4
... biotechnology research companies invested a record $58.8,billion last ... life-changing,medicines and vaccines -- an increase of nearly ... Pharmaceutical Research and Manufacturers of,America (PhRMA) and Burrill ... PhRMA,s 50th anniversary, which it observes today., ...
... China,s State Food and Drug,Administration has approved ... confocal microscope in the Peoples Republic of ... Rochester, New York-based medical device and,information company ... Lucid,s VivaScope(R) reflective confocal microscopes (RCM) ...
... CMPMedica has expanded,SearchMedica.com to include a ... medical conditions. SearchMedica.com was co-,developed with Convera ... , a,leading provider of vertical search ... ), SearchMedica.com has been serving ...
Cached Biology Technology:R&D Spending by U.S. Biopharmaceutical Companies Reaches Record $58.8 Billion in 2007 2R&D Spending by U.S. Biopharmaceutical Companies Reaches Record $58.8 Billion in 2007 3Lucid's VivaScope(R) Reflective Confocal Microscope Approved for Sale in China 2Lucid's VivaScope(R) Reflective Confocal Microscope Approved for Sale in China 3CMPMedica Expands SearchMedica.com with Multiple Additional Vertical Search Applications co-developed with Convera(R) 2CMPMedica Expands SearchMedica.com with Multiple Additional Vertical Search Applications co-developed with Convera(R) 3
96-well format (For processing samples on microplate-size MALDI target plates such as those from Bruker, Shimadzu, Thermo, and PerkinElmer) Packaging: 2 / pack...
Mouse monoclonal antibody raised against a partial recombinant CENTB2. NCBI Entrez Gene ID = CENTB2...
...
... Microarray Hybridization Wash Pack provides optimized ... slides. Preparation Quality Clarifier: Ready-to-use wash ... with SigmaScreen(tm) APS Coated Slides for ... Microarray Hybridization Blocking Buffer: 1L • ...
Biology Products: