Navigation Links
Dissecting the genetic components of adaptation of E. coli to the mouse gut
Date:1/11/2008

New insights into the evolutionary mechanisms that facilitate the remarkably fast adaptation of intestinal bacteria within their natural environment are provided in the January issue of PLoS Genetics by researchers from INSERM and INRA at University Paris Descartes.

Using germ-free mice a simplified but ecologically relevant system the authors analyzed the intestinal adaptation of a model bacterial strain, Escherichia coli MG1655. E. coli is naturally resident within the adult mammalian gut and one of the first bacteria to colonize the human intestine at birth. The mammalian intestine is therefore a privileged site to study how co-evolution between hosts and the trillions of bacteria that form the commensal flora has shaped the genome of each partner and promoted the development of mutualistic interactions.

Commensal bacteria settle on all surfaces exposed to the outside but most prominently in our intestine where they develop a high degree of interdependency with their host. Recent work has shown how these bacteria may impact on our health by modulating our metabolic functions and immune defences. Much less is known on how commensal bacteria adapt to the open and constantly changing ecosystem represented by our intestine.

Intestinal colonization of germ-free mice by E. coli was followed by the very rapid selection of bacteria carrying mutations in a master regulator that controls and coordinates the expression of over 100 target genes. The important selective advantage conferred by the mutations was related with their additive and independent effects on genes regulating bacterial motility and permeability.

These results suggest that global regulators may have evolved to coordinate physiological activities necessary for adaptation to complex environments and that mutations offer a complementary genetic mechanism to adjust the scale of the physiological regulation controlled by these regulators in distinct environments.'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3460
Public Library of Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers move 2 steps closer to understanding genetic underpinnings of autism
2. Genetic breakthrough offers promise in tackling kidney tumors
3. Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
4. Recurrent genetic deletion linked to autism
5. Study examines genetic defects linked to body abnormalities in patients with childhood cancer
6. New clinical trial results show how personalized medicine will alter treatment of genetic disorders
7. Cognitive, genetic clues identified in imaging study of alcohol addiction
8. Plant geneticists find veritas in vino
9. UT-Houstons Northrup and colleagues uncover genetic link to spina bifida
10. Study of bear hair will reveal genetic diversity of Yellowstones grizzlies
11. A research of the UGR shows the genetic predisposition to develop alcohol abuse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... addition to the hippocampus, the marginal division of ... memory. What is the impact degree of substance ... and memory function? Yan Yu and his team, ... found, using immunofluorescence staining, that substance P receptor, ... and striatal marginal division of normal rats. Unilateral ...
(Date:7/11/2014)... de Janeiro, Brazil- In the brains of all ... that allows an electric or chemical signal to ... Chemical synapses, which are the most abundant type ... Synapse formation is crucial for learning, memory, perception ... inhibitory synapses critical for brain function. For ...
(Date:7/10/2014)... July 1, 2014 Smart technology emphasis ... convenience and improved security: NXT-ID, Inc. (OTCBB: NXTD), eBay Inc. ... GOOG ), Apple Inc. (NASDAQ: AAPL ), Visa ... MA) NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company ... that the second series of 30 second spots on CNBC ...
Breaking Biology News(10 mins):Blame it on the astrocytes 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5
... known already for its role in schizophrenia ... according to a report in todays advance on-line issue ... Deaconess Medical Center (BIDMC), the study further suggests that ... diagnostic marker and therapeutic supplement for the treatment of ...
... which glows under ultraviolet light have shown that up ... cleaned. Their findings, published in BioMed Centrals journal, BMC ... bacteria Clostridium difficile (C. difficile) linger in the loo ... Michelle Alfa and a team of scientists from Manitoba, ...
... technology, DALLAS, May 7 An innovator ... will provide its proven public key,infrastructure to the ... on machine readable travel documents (MRTDs),-- also known ... nearly 23 million,citizens by the end of 2008., ...
Cached Biology News:A new gene trigger for pregnancy disorder identified 2UV lotion lights the way to cleaner facilities 2Entrust, Hewlett Packard Partner to Deploy Taiwanese ePassports, Authenticate Biometric Data 2Entrust, Hewlett Packard Partner to Deploy Taiwanese ePassports, Authenticate Biometric Data 3
(Date:7/10/2014)... July 10, 2014 Senior supply chain ... professional associations, addressed the challenges of “Reducing Cost, Lead ... Industries” through strategic sourcing. Describing the partnership of the ... Supply Chain Management Institute ( SCMI) of the ... June 24 at the Kroc Institute of Peace and ...
(Date:7/10/2014)... , July 10, 2014  Kainos Capital, a firm ... today announced that it has acquired the Slim-Fast brand ... the business. Terms of the transaction were not disclosed. ... meal replacement business that markets ready-to-drink shakes, powders, bars ... America and in the United ...
(Date:7/10/2014)... THOUSAND OAKS, Calif., July 10, 2014   Ceres, ... biotechnology and seed company, announced today financial results for ... an update on its business. Ceres reported ... progress in product performance this growing season in Brazil, ... that affected the company,s sorghum evaluation areas for part ...
(Date:7/10/2014)... WASHINGTON D.C., June 17, 2014 Using microscopic ... of specific gases, researchers at MIT,s Quantum Photonics ... detection levels in the parts-per-billion range. Optical sensors ... to their high signal-to-noise ratio, compact, lightweight nature, ... optical gas sensors had been developed before, the ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Kainos Capital Acquires Slim-Fast From Unilever 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Swell new sensors 2
... simultaneously with the tempest thermoshaker , Jeff Braman ,Stratagene , ... 1: The tempest Thermoshaker , , ... and a 96-deep-well, round-bottom plate were used ... format. Early- and mid-log phase rates of bacterial growth, ...
... system for inducible mammalian expression , , ... control mammalian expression,system ... a wide range of mammalian cell types. The,inducible promoter ... absence of,the ecdysone analog ponasterone A (ponA). In a ...
... ,Economical quantitative PCR (QPCR) reagent kits ... , Gothami Padmabandu Lisa Grismer ... quantitative PCR and RT-PCR core,reagent kits ... Several versions have been created to optionally ...
Cached Biology Technology:High-Throughput Cultivation of Bacterial Clones 2High-Throughput Cultivation of Bacterial Clones 3Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in,Mammalian Cells 2Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in,Mammalian Cells 3Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in,Mammalian Cells 4Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in,Mammalian Cells 5Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in,Mammalian Cells 6Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in,Mammalian Cells 7Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in,Mammalian Cells 8Brilliant Core Reagent Kits for QPCR and QRT-PCR 2Brilliant Core Reagent Kits for QPCR and QRT-PCR 3Brilliant Core Reagent Kits for QPCR and QRT-PCR 4Brilliant Core Reagent Kits for QPCR and QRT-PCR 5Brilliant Core Reagent Kits for QPCR and QRT-PCR 6Brilliant Core Reagent Kits for QPCR and QRT-PCR 7Brilliant Core Reagent Kits for QPCR and QRT-PCR 8Brilliant Core Reagent Kits for QPCR and QRT-PCR 9Brilliant Core Reagent Kits for QPCR and QRT-PCR 10Brilliant Core Reagent Kits for QPCR and QRT-PCR 11Brilliant Core Reagent Kits for QPCR and QRT-PCR 12Brilliant Core Reagent Kits for QPCR and QRT-PCR 13Brilliant Core Reagent Kits for QPCR and QRT-PCR 14
... Edited by N.C. Price (1996) ... information on protein chemistry and ... of proteins. Data on the ... crystalization, size determination, amino acid ...
... B.S. Dunbar (1994) • This ... principles and methods for preparing samples ... such as radiometric and bioluminescence-enhanced detection ... covered are, the detection and characterization ...
See product name for description....
RAT ANTI MOUSE TCR V BETA 7:RPE Immunogen: T-cell lymphoma TK1...
Biology Products: