Navigation Links
Dissecting the genetic components of adaptation of E. coli to the mouse gut
Date:1/11/2008

New insights into the evolutionary mechanisms that facilitate the remarkably fast adaptation of intestinal bacteria within their natural environment are provided in the January issue of PLoS Genetics by researchers from INSERM and INRA at University Paris Descartes.

Using germ-free mice a simplified but ecologically relevant system the authors analyzed the intestinal adaptation of a model bacterial strain, Escherichia coli MG1655. E. coli is naturally resident within the adult mammalian gut and one of the first bacteria to colonize the human intestine at birth. The mammalian intestine is therefore a privileged site to study how co-evolution between hosts and the trillions of bacteria that form the commensal flora has shaped the genome of each partner and promoted the development of mutualistic interactions.

Commensal bacteria settle on all surfaces exposed to the outside but most prominently in our intestine where they develop a high degree of interdependency with their host. Recent work has shown how these bacteria may impact on our health by modulating our metabolic functions and immune defences. Much less is known on how commensal bacteria adapt to the open and constantly changing ecosystem represented by our intestine.

Intestinal colonization of germ-free mice by E. coli was followed by the very rapid selection of bacteria carrying mutations in a master regulator that controls and coordinates the expression of over 100 target genes. The important selective advantage conferred by the mutations was related with their additive and independent effects on genes regulating bacterial motility and permeability.

These results suggest that global regulators may have evolved to coordinate physiological activities necessary for adaptation to complex environments and that mutations offer a complementary genetic mechanism to adjust the scale of the physiological regulation controlled by these regulators in distinct environments.

While this study yields an interesting model to analyze how intestinal bacteria can adapt to their host, the authors stress that it represents a simplified ecological system compared with the complexity prevailing within the human intestine. Future work will be necessary to assess how commensal bacteria can adapt to their host while simultaneously competing with hundreds of other bacterial species present in the intestinal microecological system.


'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3460
Public Library of Science
Source:Eurekalert

Related biology news :

1. Researchers move 2 steps closer to understanding genetic underpinnings of autism
2. Genetic breakthrough offers promise in tackling kidney tumors
3. Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
4. Recurrent genetic deletion linked to autism
5. Study examines genetic defects linked to body abnormalities in patients with childhood cancer
6. New clinical trial results show how personalized medicine will alter treatment of genetic disorders
7. Cognitive, genetic clues identified in imaging study of alcohol addiction
8. Plant geneticists find veritas in vino
9. UT-Houstons Northrup and colleagues uncover genetic link to spina bifida
10. Study of bear hair will reveal genetic diversity of Yellowstones grizzlies
11. A research of the UGR shows the genetic predisposition to develop alcohol abuse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
(Date:3/31/2016)... 2016   LegacyXChange, ... "Company") LegacyXChange is excited to release its ... to be launched online site for trading 100% guaranteed ... will also provide potential shareholders a sense of the ... an industry that is notorious for fraud. The video ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... Supplyframe, the Industry Network for electronics hardware ... . Located in Pasadena, Calif., the Design Lab’s mission is to bring together ... built and brought to market. , The Design Lab is Supplyframe’s physical representation ...
(Date:6/23/2016)... 23, 2016  Blueprint Bio, a company dedicated to ... medical community, has closed its Series A funding round, ... "We have received a commitment from Forentis ... need to meet our current goals," stated Matthew ... runway to complete validation on the current projects in ...
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... focused on quality, regulatory and technical consulting, provides a free webinar ... presented on July 13, 2016 at 12pm CT at no charge. , Incomplete ...
(Date:6/22/2016)... SAN DIEGO , June 22, 2016 /PRNewswire/ ... partnership that will allow them to produce up ... (HiPSC) from one lot within one week. These ... their time laboriously preparing cells and spend more ... made possible through a proprietary, high-volume manufacturing process ...
Breaking Biology Technology: