Navigation Links
Dissecting the genetic components of adaptation of E. coli to the mouse gut
Date:1/11/2008

New insights into the evolutionary mechanisms that facilitate the remarkably fast adaptation of intestinal bacteria within their natural environment are provided in the January issue of PLoS Genetics by researchers from INSERM and INRA at University Paris Descartes.

Using germ-free mice a simplified but ecologically relevant system the authors analyzed the intestinal adaptation of a model bacterial strain, Escherichia coli MG1655. E. coli is naturally resident within the adult mammalian gut and one of the first bacteria to colonize the human intestine at birth. The mammalian intestine is therefore a privileged site to study how co-evolution between hosts and the trillions of bacteria that form the commensal flora has shaped the genome of each partner and promoted the development of mutualistic interactions.

Commensal bacteria settle on all surfaces exposed to the outside but most prominently in our intestine where they develop a high degree of interdependency with their host. Recent work has shown how these bacteria may impact on our health by modulating our metabolic functions and immune defences. Much less is known on how commensal bacteria adapt to the open and constantly changing ecosystem represented by our intestine.

Intestinal colonization of germ-free mice by E. coli was followed by the very rapid selection of bacteria carrying mutations in a master regulator that controls and coordinates the expression of over 100 target genes. The important selective advantage conferred by the mutations was related with their additive and independent effects on genes regulating bacterial motility and permeability.

These results suggest that global regulators may have evolved to coordinate physiological activities necessary for adaptation to complex environments and that mutations offer a complementary genetic mechanism to adjust the scale of the physiological regulation controlled by these regulators in distinct environments.'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3460
Public Library of Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers move 2 steps closer to understanding genetic underpinnings of autism
2. Genetic breakthrough offers promise in tackling kidney tumors
3. Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
4. Recurrent genetic deletion linked to autism
5. Study examines genetic defects linked to body abnormalities in patients with childhood cancer
6. New clinical trial results show how personalized medicine will alter treatment of genetic disorders
7. Cognitive, genetic clues identified in imaging study of alcohol addiction
8. Plant geneticists find veritas in vino
9. UT-Houstons Northrup and colleagues uncover genetic link to spina bifida
10. Study of bear hair will reveal genetic diversity of Yellowstones grizzlies
11. A research of the UGR shows the genetic predisposition to develop alcohol abuse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... With their long, spiky legs and their propensity for ... stuff of nightmares. And now research from North Carolina ... spread into homes across the eastern United States. , ... or pose any kind of threat to humans," says ... State and lead author of a paper about the ...
(Date:9/1/2014)... An increasing amount of research shows an association between ... sedentary lifestyle. Now, a new Cornell University study points ... programs might lead people to eat twice as much ... an action movie while snacking your mouth will see ... on the new article just published in the ...
(Date:9/1/2014)... after birth, every child in the U.S. undergoes a ... conditions, including sickle cell disease. Thousands of children born ... many suffer and die from the disease each year. ... to at least some of those deaths. , ... in the lab of George Whitesides, the Woodford L. ...
Breaking Biology News(10 mins):Researchers find Asian camel crickets now common in US homes 2Can action movies make you fat? 2Faster, cheaper tests for sickle cell 2Faster, cheaper tests for sickle cell 3
... Who is related to whom, who begat whom, how did ... reptiles. In 2011, his fieldwork in Sri Lanka studying ... identity of 60 known species of snakes. With Sri Lankan ... amphibians and reptiles, and Dushantha Kandambi, a local naturalist and ...
... Copenhagen, Denmark, Shenzhen, China. Tue., 12 March 2013 ... world,s largest genomics organization, will be working together aiming ... genomics and bioinformatics capabilities of both institutions. This partnership ... food security, energy and health. , Prof Richard Cogdell, ...
... to have an ambiguous, obscure or hidden meaning. In ... are hidden inside their genes. Two University of ... tiny clams, long believed to be members of the ... along the rocky shores of southern Australia for millions ...
Cached Biology News:Sri Lankan snake study reveals new species, rich biodiversity in island country 2BGI and TGAC join efforts to tackle global challenges in food security, energy and health 2Cryptic clams: U-M biologists find species hiding in plain view 2Cryptic clams: U-M biologists find species hiding in plain view 3
(Date:9/2/2014)... /PRNewswire/ - Oncothyreon Inc. (Nasdaq: ONTY ) announced today ... Officer, will present at the Rodman & Renshaw 16 th ... on Tuesday, Sept. 9, 2014 at 2:05 p.m. ... the presentation will be accessible by visiting the Oncothyreon website ... About Oncothyreon Oncothyreon is a ...
(Date:9/2/2014)... 2014 Culot brings life science ... management services  BioData, producer of Labguru, the ... announce the appointment of Louis Culot as ... VP Marketing and Business Development at BioDiscovery Inc., developer ... applications. Previously, Culot worked for 17 years ...
(Date:8/31/2014)... 31, 2014 Wockhardt Limited today announces a ... Anti-Infective research when two of its drugs, WCK 771 ... Product (QIDP) status from U.S. Food & Drug Administration ... against pathogens which have a high degree of unmet ... for Disease Control (a top U.S. government health and ...
(Date:8/29/2014)... Aug. 29, 2014  Pfenex Inc. (NYSE MKT: ... development of high-value and difficult to manufacture proteins ... and reported financial results for the second quarter ... successful completion of our initial public offering, we ... biosimilar product candidates, derived from our proprietary protein ...
Breaking Biology Technology:Louis Culot Appointed as BioData's CEO 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8
... AdvanceBio LLC, a Cincinnati-based advanced biofuel technology company, ... fuel ethanol process. The process is capable ... sugar beet and other similar crops as feedstock for ... generating zero liquid waste. When built in ...
... TIRAT CARMEL, Israel, August 31, 2010 ... ... var shortURL = ... so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; ...
... Aug. 30 Marrone Bio Innovations (MBI) ... for the control of invasive mussels, at the ... San Diego, California, August 29 to September 2, 2010. ... representing academia, industry, government agencies, NGOs and other stakeholders ...
Cached Biology Technology:Zero Discharge Sweet Sorghum Ethanol Process Development 2InSightec Treats First Prostate Cancer Patients in Clinical Trials 2InSightec Treats First Prostate Cancer Patients in Clinical Trials 3InSightec Treats First Prostate Cancer Patients in Clinical Trials 4InSightec Treats First Prostate Cancer Patients in Clinical Trials 5InSightec Treats First Prostate Cancer Patients in Clinical Trials 6InSightec Treats First Prostate Cancer Patients in Clinical Trials 7InSightec Treats First Prostate Cancer Patients in Clinical Trials 8Marrone Bio Innovations to Present Invasive Mussel Control Solution 2
Mouse monoclonal antibody raised against a partial recombinant SCARB2. NCBI Entrez Gene ID = SCARB2...
The F40 pump maintenance kit is used to service one F40 pump of a BioLogic DuoFlow workstation. It includes 2 piston seals, 4 check valves, seal removal tool, and 2 O-rings....
...
...
Biology Products: