Navigation Links
Disparities persist in outcomes for African-American women with advanced breast cancer

(SACRAMENTO, Calif.) African-American women have poorer survival rates than their white and Hispanic counterparts regardless of whether they receive radiation therapy following lumpectomy or mastectomy, UC Davis researchers have found.

Steve Martinez, assistant professor of surgery at UC Davis Cancer Center, determined that while Hispanic and African-American women with advanced breast cancer are less likely to receive radiation therapy than their white counterparts, only African Americans have poorer outcomes than white patients with the same stage disease.

The findings, presented today in Washington, D.C., at the Association for Clinical Research Training and the Society for Clinical and Translational Science meeting, suggest that the lack of radiation therapy treatment is not responsible for the poorer survival noted among African-American patients.

"Is this a biological difference?" Martinez asks. "Do black patients benefit from post-surgery radiation therapy to the degree that Hispanics and whites benefit?"

These questions are part of Martinez' ongoing exploration of cancer health disparities as they affect patients' response to therapy and overall survival. A surgical oncologist, Martinez is one of many clinicians at UC Davis Cancer Center who also are finding ways to address the disproportionate cancer burden for certain patient populations.

The current study is one of two Martinez undertook to examine factors influencing survival for breast cancer patients. In the first, he looked at data from more than 12,000 women from throughout the country who had breast cancer that had spread to 10 or more lymph nodes and that had resulted in either lumpectomy or mastectomy.

"By definition, all of these patients should get radiation therapy," he said.

What he found was that Hispanic patients were 20 percent less likely to get radiation therapy than their white counterparts, and black patients were about 24 percent less likely to receive radiation therapy.

For the second study, he wanted to learn whether the disparities in receipt of radiation therapy resulted in poorer outcomes for Hispanic and African-American women.

"That is not what we found," he said. "Hispanic patients were not significantly different from white patients in overall survival rates, but black patients did worse. This survival disparity seen in black patients was unrelated to whether or not they received radiation therapy as part of their treatment."

Martinez examined 10-year survival rates in patients from each group who received radiation therapy and those who did not. While he found dramatic differences in survival for white women who had radiation therapy (an 11 percent survival boost), black patients had just a 3 percent difference in their survival rates.

Martinez plans to continue his research into factors that may influence whether or not patients receive radiation therapy and that may also affect their outcomes, including possible biological differences.

"We are trying to see which treatments work best for which people," he said. "Ultimately, we can figure out treatments that may work well for you, but not for someone else. This is a step on that path."


Contact: Dorsey Griffith
University of California - Davis - Health System

Related biology news :

1. How do race, genetics and health-care disparities affect spread of HIV?
2. Racial disparities in cardiovascular health linked to birth weight, slavery
3. American Association for Cancer Research hosts Science of Health Care Disparities Meeting
4. American Association for Cancer Research hosts Science of Cancer Health Disparities conference
5. Differences in neighborhood food environment may contribute to disparities in obesity
6. Persistent man-made chemical pollutants found in deep-sea octopods and squids
7. Pesticides persist in ground water
8. Bacterial persistence in streams
9. Persistent pollutant may promote obesity
10. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
11. Treatment delays result in poor outcomes for men with breast cancer
Post Your Comments:
(Date:10/29/2015)... 2015 Daon, a global leader in mobile ... a new version of its IdentityX Platform , ... America have already installed IdentityX v4.0 and ... FIDO UAF certified server component as an ... FIDO features. These customers include some of the largest ...
(Date:10/27/2015)... NEW YORK , Oct. 27, 2015 ... the major issues of concern for various industry verticals ... This is due to the growing demand for secure ... practices in various ,sectors, such as hacking of bank ... concerns for electronic equipment such as PC,s, laptops, and ...
(Date:10/26/2015)... , Oct. 26, 2015  Delta ID Inc., ... authentication to mobile and PC devices, announced its ActiveIRIS® ... the arrows NX F-02H launched by NTT DOCOMO, INC ... F-02H is the second smartphone to include iris recognition ... in ARROWS NX F-04G in May 2015, world,s first ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... ... ... Matthew “Tex” VerMilyea, PhD, HCLD, has joined Texas Fertility Center as its ... procedures as well as continue his research efforts into the emerging technologies of embryo ... Zealand to bring home a High Complexity Clinical Laboratory Director named Tex,” says ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... Global Stem Cells Group announced ... clinics in the cities of Arica and Iquique in northern Chile. The facilities are part ... offer the most advanced protocols and techniques in stem cell medicine to patients from around ...
(Date:11/30/2015)... Harvard Apparatus Regenerative Technology, Inc. (HART) ... bioengineered organ implants for life-threatening conditions, today announced ... Stock Market that it has regained compliance with ... that as a result of the closing bid ... per share for more than ten consecutive business ...
(Date:11/30/2015)... 30, 2015 Human Longevity, Inc. (HLI), the ... acquired Cypher Genomics, Inc., a leading genome informatics company ... software solutions. The San Diego -based ... Cypher CEO and Co-founder, Ashley Van Zeeland , Ph.D., ...  Financial details of the deal were not disclosed. ...
Breaking Biology Technology: