Navigation Links
'Disordered' amino acids may really be there to provide wiggle room for signaling protein
Date:5/26/2009

resonance spectroscopy, which can determine a protein's shape by measuring how the individual atomic nuclei of a protein interact with an intense magnetic field.

Since NMR spectroscopy works best with small proteins not large flexible molecules like NHREF1 Roder, his staff scientist Hong Cheng, Ph.D., and their colleagues came up with an innovative technique that allowed them to look at the protein from numerous angles with the NMR spectrometer, and subtract out the overlapping areas to form a more complete picture of the molecule. This picture enabled them to see what NHREF1 looks like in both its "on" and "off" conformation.

"When it is not working, the protein is in this 'off' conformation until acted upon by outside agents" Roder says. "It is a way for the cell to shut off a signaling pathway when it is not in use."

According to Roder, these findings may provide researchers a new way of looking at proteins like NHERF1 and their physiological role in cells.


'/>"/>

Contact: Greg Lester
gregory.lester@fccc.edu
215-728-2753
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. U of M research finds disordered eating less common among teen girls who regularly eat family meals
2. Mixing large doses of both acetaminophen painkiller and caffeine may increase risk of liver damage
3. Unique pattern of gene expression can indicate acetaminophen overdose
4. Ibuprofen or acetaminophen in long-term resistance training increases muscle mass/strength
5. Model tissue system reveals cellular communication via amino acids
6. Omega-3 fatty acids protect against Parkinsons, study says
7. Typical North American diet is deficient in omega-3 fatty acids
8. Trans-fatty acids and insulin sensitivity
9. Scientists suspect omega-3 fatty acids could slow acute wound healing
10. Foods high in conjugated linoleic acids can enrich breast milk
11. When is a stem cell not really a stem cell?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... of increasing concern about the prevalence of antibiotic-resistant ... promising new pathway to disabling disease: blocking bacteria,s ... scientists showed how bacterial siderophore, a small molecule, ... fan bacterial growth as well as how ... infection process. Their findings appear in a recent ...
(Date:7/9/2014)... upon us, many backyard cooks are turning to more ... But low fat can sometimes mean low satisfaction. Now ... problem in low-fat wieners that are made with olive ... in ACS, Journal of Agricultural and Food Chemistry ... hot-dog consumers have come to expect just the right ...
(Date:7/9/2014)... challenges the commonly held belief that birds evolved from ... The birdlike fossil is actually not a dinosaur, as ... tiny tree-climbing animal that could glide, say American researchers ... and Alan Feduccia of the University of North Carolina. ... . , The fossil of the Scansoriopteryx ...
Breaking Biology News(10 mins):Bacteria hijack plentiful iron supply source to flourish 2Researchers declassify dinosaurs as being the great-great-grandparents of birds 2
... Smithsonian,s Barro Colorado Island research station in Panama, organized ... Science, Policy & Management at the University of California, ... since the first census 33 years ago. Long ... and a group of stalwart volunteers, each armed with ...
... for Marine Sciences at the University of Gothenburg have discovered ... Gullmarsfjord north of Gothenburg. The bacterium has been named ... center. Researcher Matthias Obst from the Department of ... Sven Lovn Centre for Marine Sciences, a new institute owned ...
... and calcium supplements appear to reduce the risk of breast ... Cancer Research 101st Annual Meeting 2010. "It is ... and your breast cancer risk is reduced tomorrow," said Jaime ... Puerto Rico. "However, we did see a long-term effect in ...
Cached Biology News:A howling success: The fifth howler monkey census on Barro Colorado Island 2
(Date:1/14/2014)... Communications, a leading provider of strategic communications services to corporations and ... the United States and Europe ... JD, is returning to the firm,s Washington, D.C. ... more than two years of service as Associate Commissioner for the ...
(Date:1/14/2014)... 2014 The largest international professional organization of ... therapeutic derivatives thereof has endorsed an educational program ... the challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 In recent ... motives and methods in product development and promotion has ... industry. This mistrust, fueled by concerns about the insidious ... by reports of spectacular fines to the world’s biggest ...
(Date:1/14/2014)... Ontario , Jan. 14, 2014   Kinaxis ®, provider ... SCM ) and sales and operations planning ( S&OP ) ... Biomanufacturing Summit , which will be held at the ... the conference, join Kinaxis customer Elisabeth Kaszas , Director ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... Roche Diabetes Care, makers of ACCU-CHEK® products and services, ... diabetes education, awareness and advocacy. The company has also ... North America. Roche Diabetes Care,s Facebook ... www.twitter.com/accuchek_us ) accounts have been created with one goal ...
... In some areas of Virginia, blackbirds are causing moderate to ... the state has issued a Section 18 exemption to the ... farmers to use Avipel® Crop Seed Treatment to protect their ... of bird damage to crops is not unique to this ...
... 2011 DDC (DNA Diagnostics Center), the largest provider of ... and worldwide, invites international attendees for a tour and behind ... 2011 at 3 p.m. at DDC, One DDC Way, Fairfield, ... Network Conference: An International Exploration of Wrongful Conviction held in ...
Cached Biology Technology:Roche Diabetes Care in the U.S. Turns to Social Media to Promote Diabetes Education, Awareness and Advocacy 2Roche Diabetes Care in the U.S. Turns to Social Media to Promote Diabetes Education, Awareness and Advocacy 3Bird Repellent Gains Approval by Virginia 2DDC to Name DNA Analyzer "Hello Truth" During Innocence Project International Delegate Tour 2
Human peripheral blood PBMCs, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood PBMC and T Cells...
Umbilical cord blood CD14+ Monocytes, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Human peripheral blood CD8+ T cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood PBMC and T Cells...
Human peripheral blood CD56+ NK cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Biology Products: