Navigation Links
Disease genes that followed the Silk Road identified
Date:7/20/2010

Scientists have identified key genes responsible for a severe inflammatory disease that has spread along the old silk trading routes from the Far East to the edge of Europe.

University of Manchester researchers, working as part of a large international consortium, have revealed some of the genetic mutations that lead to Behet's disease. The group's findings are published in Nature Genetics.

Behet's is a vascular disease where the body's normal inflammatory immune response becomes overactive and destroys blood vessels resulting in severe mouth and genital ulcers and skin lesions. The eyes can also be affected by the condition and this can lead to blindness.

The condition, sometimes referred to as the 'Silk Road disease' due to the way its prevalence has spread along the old silk trading routes, is rare in Western Europe but is a major disease in Far- and Middle-Eastern countries, as well as in Greece and, particularly, Turkey, where it affects four in every 1,000 people.

"Our research has for the first time in a large-scale study identified the genes responsible for Behet's disease," said Bill Ollier, Professor of Imunogenetics and Director of the University's Centre for Integrated Genomic Medical Research (CIGMR).

"The condition is relatively rare in the UK, mainly affecting those of Asian and Middle-Eastern descent, but its hereditary nature has seen its prevalence spread westward from the Far East as trading routes opened and populations migrated."

The researchers carried out genetic tests on almost 2,500 Turkish volunteers, 1,215 people with Behet's disease and 1,278 healthy individuals. The scientists compared their results with additional data from a further 5,000 people in Turkey, the Middle East, Europe and Asia.

The team found an increased risk of disease was associated with three genes HLA-B51, IL10, IL23R-IL12RB2. There is also evidence to suggest the involvement of two further genes in this condition. The discovery could pave the way for new treatments for Behet's in the future.

Professor Ollier said: "Through establishing this major international collaboration between research groups from all over the world we have managed to identify and confirm some of the genes involved in this terrible condition.

"Hopefully, if we can collect larger numbers of patients, we will be able to go on to identify further genes which contribute smaller levels of risk. By identifying the genetic factors in Behcet's disease we will be in a position to establish the biological and biochemical pathways that cause the disease pathology. Only by doing this, will we be able to design the right drugs to correct these pathways and treat the patients.

"Our other long-term ambition is that we could use genetic testing to identify early cases in families with a history of the disease and predict which patients will have a more severe disease course and consequently require a more aggressive therapy."


'/>"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert

Related biology news :

1. Scientists discover clues to inflammatory disease
2. Waterborne diseases could cost over $500 million annually in US
3. Plavix may be treatment for dogs at risk of thromboembolic disease
4. Modulator of fetal hemoglobin switch may target sickle cell disease
5. Mount Sinai researchers discover new way diseases develop
6. Reprogrammed human blood cells show promise for disease research
7. Virgin olive oil and a Mediterranean diet fight heart disease by changing how our genes function
8. TGen-led studies identify genetic links to kidney disease, kidney failure
9. Researchers at UH work to prevent neurological diseases
10. Climate change complicates plant diseases of the future
11. How genetic chips could help to understand heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... -- Research and Markets has announced the addition of ... Industry Forecast to 2025" report to their offering. ... The Global Vehicle Anti-Theft ... 8.8% over the next decade to reach approximately $14.21 billion by ... and forecasts for all the given segments on global as well ...
(Date:3/20/2017)... ALLENTOWN, Pa. , March 20, 2017 ... PD 2.0 personal spirometer and Wellness Management System (WMS), ... Founded in 2010, PMD Healthcare is a ... Company with a mission dedicated to creating innovative solutions ... of life. With that intent focus, PMD developed the ...
(Date:3/7/2017)... , March 7, 2017 Brandwatch , the ... by The Prince,s Trust to uncover insights to support ... The Trust. The UK,s leading youth charity will be ... campaign results and get a better understanding of the topics and ... ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... Linda, Ca (PRWEB) , ... April 20, 2017 ... ... University Virtual Event , this new webinar will explore challenging patient cases when ... admitted to the hospital, there may be a need for bridging parental anticoagulation ...
(Date:4/20/2017)...  Eli Lilly and Company (NYSE: LLY ... the prevention of migraine at the American Academy of ... 22-28, 2017, in Boston . ... including safety and patient outcomes data for galcanezumab in ... in monthly migraine headache days among patients with episodic ...
(Date:4/20/2017)... ... April 20, 2017 , ... ... scientific and clinical research community’s growing body of knowledge during its Eighth ... Gracie Theatre and the adjacent Darling Atrium. During the event, undergraduates, graduate students, ...
(Date:4/20/2017)... LAVAL, QC , April 20, 2017 /PRNewswire/ - Prometic Life ... today presented new results at the International Liver Congress ("ILC") ... Liver ("EASL") in Amsterdam on the ... in a mouse model of obesity and metabolic syndrome. ... According to Dr. Lyne Gagnon, ...
Breaking Biology Technology: