Navigation Links
Discovery to aid in future treatments of third-world parasites
Date:7/27/2009

Saranac Lake, NY - Schistosomiasis, one of the most important of the neglected tropical diseases, is caused by infection with parasitic helminths of the genus Schistosoma. These parasites are long lived (>10 years) and dwell within blood vessels, where they produce eggs that become the focus of intense, chronic inflammatory responses. In severe cases, this inflammation is associated with life-threatening liver disease.

No vaccine is currently available to prevent schistosomiasis. Options for treating the disease are largely limited to one drug, Praziquantel. Rates of re-infection in drug-treated individuals are high, and it is feared that widespread use may foster the emergence of drug-resistant variants, such as has seen with drug-resistant strains of tuberculosis.

The body's immune response to schistosome infection, as with all immune responses, is coordinated by cytokines, small proteins secreted by immune cells. Due to their fundamental importance, cytokine research is a significant focus of research at the Trudeau Institute. Because cytokines travel through the body to relay critical information, it is difficult to identify the cells that produce them and to learn about their role.

Trudeau investigators have devised cytokine "reporter mice" for tracking cells that produce the signature cytokine of the so-called "Th2" immune response mounted against infections with parasitic worms, interleukin-4 (IL-4).

While it was previously known that the complex mixture of proteins released by schistosome eggs induce Th2 responses and the production of IL-4, the specific molecule(s) responsible for these effects were unknown.

Research from the laboratories of Markus Mohrs of the Trudeau Institute and Gabriele Schramm of the Research Centre Borstel in Germany had previously shown that a protein called alpha-1 can support Th2 responses but is unable to initiate them.

However, new findings from an international study between Mohrs, Schramm, and Maria Yazdanbaksh of the Leiden University Medical Center in the Netherlands have now shown that omega-1, a single protein secreted from schistosome eggs, recapitulates the activities of the complex mixture in the test tube (in vitro).

Importantly, using IL-4 reporter mice, the researchers show that omega-1 alone is sufficient to generate Th2 responses in vivo. This identification of a single protein will undoubtedly aid in unlocking the molecular pathways inducing Th2 responses commonly elicited by infection with parasitic worms.

Ultimately, these novel insights will help researchers in the field like Dr. Yazdanbaksh, who, in addition to her laboratory research, also oversees studies in schistosomiasis patients in Africa.

These findings are reported in the current issue of the Journal of Experimental Medicine.

As with all basic research discoveries, incremental advances such as these may eventually lead to new treatments and therapies that will improve the day-to-day lives of the 200 million people around the globe currently afflicted by schistosomiasis. Moreover, these Th2 responses, described above in the context of worm infections, are also associated with the clinical symptoms of allergic and asthmatic disorders. Thus, understanding the immune response to infection with parasitic worms might aid in ameliorating allergy and asthma common in industrialized countries.


'/>"/>

Contact: Brian Turner
bturner@trudeauinstitute.org
518-891-3080
Trudeau Institute
Source:Eurekalert  

Related biology news :

1. New discovery suggests trees evolved camouflage defense against long extinct predator
2. Down Under dinosaur burrow discovery provides climate change clues
3. GUMC discovery highlights new direction for drug discovery
4. Discovery may provide new treatments for alcohol dependence
5. New nanoparticles could revolutionize therapeutic drug discovery
6. Discovery of a water snake that startles fish in a way that makes them flee into its jaws
7. New discovery suggests mammoths survived in Britain until 14,000 years ago
8. Discovery of the cells water gate may lead to new cancer drugs
9. Aussie and Kiwi researchers make double MS genetic discovery
10. Discovery raises new doubts about dinosaur-bird links
11. NAU discovery could help feed millions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery to aid in future treatments of third-world parasites
(Date:4/11/2017)... , April 11, 2017 NXT-ID, Inc. ... technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate governance ... Gino ... we look forward to their guidance and benefiting from their ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... to expand at a CAGR of 25.76% during the ... is the primary factor for the growth of the ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem ... technology, application, and geography. The stem cell market of ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... ... Disappearing forests and increased emissions are the main causes of the evolving ... those living in larger cities are affected by air pollution related diseases. , That ... countries globally - decided to take action. , “I knew I had to take ...
(Date:10/10/2017)... SAN DIEGO, CALIF. (PRWEB) , ... October 10, 2017 , ... ... website as part of its corporate rebranding initiative announced today. The bold new ... broaden its reach, as the company moves into a significant growth period. , It ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO of ... Rotary Club. The event entitled “Stem Cells and Their Regenerative Powers,” ... Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, ...
(Date:10/10/2017)... BARBARA, CALIFORNIA (PRWEB) , ... October 10, 2017 ... ... management, technological innovation and business process optimization firm for the life sciences and ... BoxWorks conference in San Francisco. , The presentation, “Automating GxP Validation ...
Breaking Biology Technology: