Navigation Links
Discovery that PARP protein exists in all breast tumors will help target chemo and predict response
Date:3/26/2010

chemotherapy can be targeted precisely at cancer cells, while leaving normal, healthy cells relatively untouched. A recent conference presentation* showed that the simultaneous use of a PARP inhibitor with DNA-damaging chemotherapy in breast cancer could improve overall survival. The potential role of PARP inhibitors as a new anticancer agent is currently under research in a number of other studies.

Professor von Minckwitz's team used tissue from 646 patients in a neoadjuvant Phase III trial (GeparTrio) to look for the presence of PARP and to correlate its existence with other prognostic factors and total response to chemotherapy. Neoadjuvant chemotherapy is given to patients before other treatments such as surgery or radiotherapy. They found that, although PARP was present in all tumour subtypes, it occurred most frequently in HER2 positive and triple negative tumours, and that it correlated with most known prognostic factors, except HER2.

"The relationship to total response was remarkable," says Professor von Minckwitz. "Tumours with a high level of PARP expression had a total response in 26% of cases, whereas those tumours which did not express PARP had a total response in only 9%. Additionally, we found that the presence of PARP can provide more accurate prognostic information than the grade of differentiation or degree of abnormality of tumours. We believe that this is the first study to describe a broad expression of PARP in untreated breast tumours together with a correlation of sensitivity to chemotherapy."

PARP positive tumours could become a new entity in breast cancer, the investigators say. They intend to follow up their initial findings by a trial randomising patients to either chemotherapy alone or chemotherapy plus a PARP inhibitor. "Particularly in triple-negative tumours there is a great need to improve treatment options," says Professor von Minckwitz. "Apart from chemotherapy, there is no other treatment such as endocrin
'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
ECCO-the European CanCer Organisation
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Chance discovery leads to plant breeding breakthrough
2. A-maize-ing discovery could lead to higher corn yields for food, feed and fuel
3. African bird discovery proves there is something new under the sun
4. Discovery in legumes could reduce fertilizer use, aid environment: Stanford researchers
5. Startup joins UCLA tech incubator to develop technologies for drug discovery, screening
6. An electrifying discovery: New material to harvest electricity from body movements
7. New gene discovery could help to prevent blindness
8. First discovery of the female sex hormone progesterone in a plant
9. Enlisting a drug discovery technique in the battle against global warming
10. TGen becomes center of excellence for Horizon Discoverys GENESIS and X-MAN technology
11. Gene function discovery: Guilt by association
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... expected to contribute to a very large and potentially ... a University of Michigan ecologist and colleagues who released ... Chesapeake Bay. , The Gulf forecast, one of two ... for an oxygen-depleted, or hypoxic, region of between 7,286 ... the 10 largest on record. , The low end ...
(Date:6/18/2013)... Faculty of Medicine have discovered a mechanism that is ... a component of blood typically associated with clotting, were ... detection, seal it off from the rest of the ... Immunology this week, provide the science community with ... has known that platelets do participate in immunity, but ...
(Date:6/18/2013)... very large "dead zone" in the Gulf of Mexico ... Chesapeake Bay this year, based on several NOAA-supported forecast ... Louisiana State University, and the Louisiana Universities Marine ... hypoxic "dead" zone will be between 7,286 and 8,561 ... largest recorded. That would range from an area the ...
Breaking Biology News(10 mins):U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone' 2U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone' 3U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone' 4Immunity mechanism discovered 2NOAA, partners predict possible record-setting deadzone for Gulf of Mexico 2NOAA, partners predict possible record-setting deadzone for Gulf of Mexico 3NOAA, partners predict possible record-setting deadzone for Gulf of Mexico 4
... tissue in those spare tires and lower belly pooches ... is an active organ that sends chemical signals to ... heart attacks, cancer, and other diseases. They are reporting discovery ... to be secreted into the blood by human fat cells ...
... LONDON, Oct. 13 The 2010 Frost & ... Verification Components and Systems is presented to Fingerprint ... ) (Logo:  http://www.newscom.com/cgi-bin/prnh/20081117/FSLOGO) "For ... in the biometrics industry with the prime focus ...
... October 13, 2010) Before Alzheimer,s patients experience memory loss, ... A new study in mouse models by researchers ... mitochondria -- the powerhouses of the cell -- are one ... appeared in the online Early Edition of PNAS, also found ...
Cached Biology News:Frost & Sullivan Honours Fingerprint Cards AB with Product Line Strategy Award 2Frost & Sullivan Honours Fingerprint Cards AB with Product Line Strategy Award 3Frost & Sullivan Honours Fingerprint Cards AB with Product Line Strategy Award 4Early role of mitochondria in AD may help explain limitations to current beta amyloid hypothesis 2
(Date:6/18/2013)... Angeles, CA (PRWEB) June 18, 2013 (PRWEB) June ... construction’s #1 time and attendance system in North ... software that shares employee data and payroll records ... AccountLinx Plus automates ExakTime software setup ... The software imports employee data from a business’ ...
(Date:6/18/2013)... Wilmington, DE (PRWEB) June 18, 2013 ... teachers to the 11th annual DuPont National AgriScience Teachers ... Chesapeake Farms in Chestertown, Md. , ... sponsored by DuPont and is a special project of ... National Association of Agricultural Educators (NAAE) . The ...
(Date:6/18/2013)... -- regulated information — Global biopharmaceutical company UCB, Inc. and ... launch of a new Pledge campaign for people with ... empowers the millions of Americans living with ... commitment to demand more: greater understanding of the condition, ... partial-onset seizure control.  More information is available at ...
(Date:6/18/2013)... ZIONA, Israel , June 18, 2013 /PRNewswire/ ... bulk Active Pharmaceutical Ingredients (APIs), generic and innovative intermediates, and ... today that the company has been granted a ... in the US and Europe for ... Patent number 8,410,176 B2 is titled Intermediate Compounds and ...
Breaking Biology Technology:ExakTime Introduces AccountLinx Plus 2DuPont Sponsors National AgriScience Ambassador Academy 2DuPont Sponsors National AgriScience Ambassador Academy 3Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 2Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 3Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 4Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 5Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 6Mapi Pharma Granted United States Patent for Pain Relief Medication "Tapentadol" 2
... SEATTLE, May 5 On Thursday, May 8, ... Pacific members of,Cell Therapeutics, Inc.,s (CTI) (Nasdaq: ... conference call to discuss the company,s 2008 first,quarter ... Numbers Thursday, May 8 8:30 a.m. ...
... May 5 VaxGen,Inc. (OTC Bulletin Board: VXGN.OB), ... sale of all assets and rights related to ... and,related technology to Emergent BioSolutions, Inc. Under the ... million upon execution of,the definitive agreement and may ...
... shrink, even tiny defects in the lines, dots and ... performance. Princeton engineers have now found a way to ... could dramatically improve chip quality without increasing fabrication cost. ... of Nature Nanotechnology, enables more precise shaping of microchip ...
Cached Biology Technology:VaxGen Sells Anthrax Vaccine Program and Related Assets and Technology to Emergent BioSolutions, Inc. 2Melting defects could lead to smaller, more powerful microchips 2Melting defects could lead to smaller, more powerful microchips 3Melting defects could lead to smaller, more powerful microchips 4
Rabbit anti-Junctophilin-4 (C-term)...
SpectroQuest single beam 4nm UV/Vis spectrophotometer; stand-alone unit; large angled LCD screen; large sample compartment...
... Crystal / Mount is the standard ... is designed especially for the permanent preservation ... sections. It is easy to use and ... is the first aqueous mounting medium that ...
... development to targets including proteins and to ... cancer-specific surface antigens. A&Gs service is ... in approximately 40 days (duration may vary ... Phase I: Immunization, test bleed and ...
Biology Products: