Navigation Links
Discovery suggests way to block fetal brain damage produced by oxygen deprivation
Date:9/1/2011

LA JOLLA, CA September 1, 2011 Examining brain damage that occurs when fetuses in the womb are deprived of oxygen, researchers at The Scripps Research Institute have discovered that damage does not occur randomly but is linked to the specific action of a naturally occurring fatty molecule called LPA, acting through a receptor that transfers information into young brain cells.

This observation made in mice suggests that LPA may also be linked to the damage caused by oxygen deprivation in human fetuses. If that proves to be the case, the research may help scientists and physicians better understand and find new ways to address the numerous developmental disorders that can arise when fetuses are deprived of oxygen in the wombincluding mental retardation, epilepsy, schizophrenia, autism, cerebral palsy and a range of other physical and mental problems.

"Fetal brain damage from oxygen deprivation involves specific changes that are, surprisingly, mediated by this lipid signal called LPA," said Scripps Research Professor Jerold Chun, MD, PhD, a member of the Dorris Neuroscience Center who led the research, which appeared in an advance, online issue of the journal Proceedings of the National Academy of Sciences (PNAS) this week.

"Because this pathway can be targeted with drugs," he added, "the discovery suggests that creating new medicines that target LPA receptors may be a way of limiting or preventing serious developmental brain diseases."

Currently, there is no way to treat the neurological damage produced by oxygen deprivation.

How Lack of Oxygen Affects the Fetal Brain

A developing fetus might be temporarily deprived of oxygena condition known as "hypoxia"for any number of reasons, including disruption of blood flow, exposure to smoke, carbon monoxide, or physical trauma.

Physicians have long known that hypoxia can lead to brain damage and i
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Illinois-UC Berkeley discovery turns seaweed into biofuel in half the time
2. Fossil discovery represents new milestone in early mammal evolution
3. Genomatix, USU and HJF execute a CRADA: Prostate cancer prognostic marker discovery by NGS
4. Biologists discovery may force revision of biology textbooks
5. Single, key gene discovery could streamline production of biofuels
6. Rediscovery of disappeared species: Truly back from the brink?
7. New discovery positions Smithsonian to bolster genetic diversity among cheetahs
8. Trudeau Institute announces new discovery in battle against infections
9. B-cell discovery suggests why women suffer more autoimmune disease
10. New discovery brings customized tuberculosis therapies based on genotype closer to reality
11. Plant immunity discovery boosts chances of disease-resistant crops
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... its launch in December 2014, the 1U™ app ... trying to remember their usernames and passwords through replacing the ... To assist people who have struggled to remember usernames and ... and focuses on redefining identity, announced today that it is ...
(Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has ... America Perimeter Security Systems Market" report to their offering. ... North American perimeter security market is estimated to grow at ... U.S. market holds a larger share in this market, ...
(Date:12/17/2014)... SM announced today its completion of a Good ... current U.S. Food and Drug Administration (FDA) regulations. This ... smart phone application trials utilizing the highest principles for ... determined to improve global healthcare access, quality, and delivery ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... Twenty years after its introduction, gene therapy still holds great ... viruses such as human immunodeficiency syndrome (HIV). But scientists have ... system that is capable of delivering therapeutic payloads to specific ... researchers in the USC Viterbi School of Engineering may be ...
... can safely drive while talking on their cell phones. Vanderbilt ... when it comes to handling two things at once, your ... it that with our incredibly complex and sophisticated brain, with ... a thousand times a second, we still have such a ...
... the National Institutes of Health have developed an experimental ... infected with cytomegalovirus (CMV)—a common virus that can also ... who were infected in early fetal life. , Estimates ... each year at about 40,000, and there is no ...
Cached Biology News:Can engineered immune cells stop AIDS? 2Can engineered immune cells stop AIDS? 3Neural bottleneck found that thwarts multi-tasking 2Neural bottleneck found that thwarts multi-tasking 3Experimental vaccine given during pregnancy reduces stillbirths from common virus 2Experimental vaccine given during pregnancy reduces stillbirths from common virus 3
(Date:1/22/2015)... Crystal Diagnostics (CDx) Xpress System, a rapid ... AOAC-PTM Certifications for the six non-O157 Shiga toxin-producing E. coli ... to as STEC or the “Big-6”) as well as Escherichia ... per 325 g of raw ground beef and raw beef ...
(Date:1/22/2015)... WI (PRWEB) January 22, 2015 Dr. Greg ... the 12th annual Scripps Natural Supplements Pre-Conference seminar on probiotics ... Conference is an annual continuing education conference for health care ... and included the topic of probiotics in health. Dr. Leyer ...
(Date:1/22/2015)... 2015 Diagenode, Inc., a leading ... Bioruptor® and complete solutions for epigenetics research, recently ... alleviating the need for manual processing. The new ... ChIP of histones or transcription factors and a ...
(Date:1/22/2015)... , Jan. 22. 2015  Varian Medical Systems (NYSE: ... has been honored for its commitment to sustainability with inclusion ... Varian is the highest ranked healthcare equipment company among the ... during the World Economic Forum at Davos, Switzerland ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Varian Honored Among World's 100 Most Sustainable Corporations 2
... 2011 The Plasma Protein Therapeutics Association (PPTA) ... to Orphan Drugs Act ( H.R. 2672 ) and ... drugs and therapies that treat patients with rare diseases by ... who rely on plasma protein therapies are coping with a ...
... NOVATO, Calif., July 28, 2011 BioMarin Pharmaceutical Inc. (Nasdaq: ... GALNS Phase 1/2 extension study (MOR-100) in which patients have ... originally enrolled in the initial Phase 1/2 study of GALNS ... (MOR-100).  In the MOR-100 study, patients were treated at a ...
... fight over deficit reform continues to drag on in Washington, ... across the region to fight to save a critical sector ... a victim of short-sighted cuts. "Proposed cuts to ... to seniors, but would require seniors to pay more for ...
Cached Biology Technology:PPTA Praises Legislation That Protects the Treatment of Rare Diseases 2BioMarin Provides Update on GALNS Phase 1/2 Extension Study (MOR-100) 2BioMarin Provides Update on GALNS Phase 1/2 Extension Study (MOR-100) 3BioMarin Provides Update on GALNS Phase 1/2 Extension Study (MOR-100) 4BioMarin Provides Update on GALNS Phase 1/2 Extension Study (MOR-100) 5BioMarin Provides Update on GALNS Phase 1/2 Extension Study (MOR-100) 6Biotech Group Warns Proposed Medicare Cuts Could Hurt Critical Sector of New England Economy 2
...
... a-Amylase is an enzyme that catalyzes ... of maltose, maltotriose, and dextrins. The,level ... the human body is of,clinical significance ... including,pancreatitis and diabetes; plant and microbial ...
... Jouan MSC series of Class II ... conditions and certification to the world's ... ensures that the cabinets cannot be ... Natural lighting, low noise and arm ...
... Fluoroskan Ascent FL is ... and luminometric measurement technologies ... list of advanced features ... Luminoskan Ascent. Fluoroskan Ascent ...
Biology Products: