Navigation Links
Discovery spotlights key role of mystery RNA modification in cells
Date:1/6/2014

lity are connected to this, and I'm sure we'll find many other connections."

The demethylases are commonly called erasers. Working alongside eraser proteins are "writer" and "reader" proteins. Writer proteins are the ones that insert methyls into RNA. He's group discovered the first two known eraser proteins since 2011. His group has also identified at least two writer proteins, and many readers, including YTHDF2 that selectively binds m6A in mRNA and controls the mRNA stability as described in their Nature paper.

"YTHDF2 is the first reader protein we have characterized. In fact, it is the first m6A reader protein characterized so far," He said.

Reader proteins endow biological function. "Something has to read a methyl to give it a biological function," He explained. "When you take out the methyl the readers will not read, so there's the regulation. When you put a methyl in, the reader will read." The Nature paper presents the first discovery of a direct link between RNA methylation and biological function, one that tunes the lifetime of mRNA. "Hopefully, I'll have more to report in the future," He said.

Gaining a better understanding of RNA modification may eventually help drug developers devise small molecules that can tune gene expression to kill or control diseased cells, but years of more fundamental research still lies ahead.

"What we have discovered here is a very fundamental biology," He said. "Next we'll look into development, cell differentiation, even neurobiology. This could impact almost every aspect of biology."


'/>"/>

Contact: Steve Koppes
skoppes@uchicago.edu
773-702-8366
University of Chicago
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Genetic discovery points the way to much bigger yields in tomato, other flowering food plants
2. Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery
3. Life Sciences Discovery Fund announces R&D grants
4. Chicago scientist involved in discovery of 4 new mammal species in Democratic Republic of Congo
5. U-M tinnitus discovery opens door to possible new treatment avenues
6. New discovery on how skin cells form bridges paves the way for advances in wound healing
7. Environment drives genetics in Evolution Canyon; discovery sheds light on climate change
8. CNIO study chosen as discovery of the year in regenerative medicine
9. Canadian researchers lead groundbreaking discovery in deadly childhood cancer
10. Surprising discovery: The skin communicates with the liver
11. Discovery of partial skeleton suggests ruggedly built, tree-climbing human ancestor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery spotlights key role of mystery RNA modification in cells
(Date:9/19/2014)... the sake of fairness per se but in order ... Frans de Waal, PhD, and Sarah Brosnan, PhD, co-authors ... is defined as a negative reaction to unequal outcomes. ... , Their conclusion comes after the co-authors reviewed more ... it is the evolution of forestalling partner dissatisfaction with ...
(Date:9/19/2014)... study shows that legume plants regulate their symbiotic ... that are transmitted through the plant structure from ... of bacteria-holding nodules in the roots. This collaborative ... Institute for Basic Biology, the Graduate University for ... Sustainable Resource Science in Japan. , Legumes, ...
(Date:9/18/2014)... A sleep-promoting circuit located deep in the primitive ... Discovered by researchers at Harvard School of Medicine and ... Sciences, this is only the second "sleep node" identified ... both necessary and sufficient to produce deep sleep. , ... the study demonstrates that fully half of all of ...
Breaking Biology News(10 mins):Evolution of responses to (un)fairness 2Evolution of responses to (un)fairness 3For legume plants, a new route from shoot to root 2No sedative necessary: Scientists discover new 'sleep node' in the brain 2
... number of rivers and lakes are being invaded by exotic ... Such species represent a threat to native species, as they ... the case of the mudsnail Potamopyrgus antipodarum ... and has spread throughout rivers, lakes or streams in Europe, ...
... found that silicone foul release coatings may be an important ... water and hydropower infrastructure. Allen D. Skaja, Ph.D., PCS, of ... metal alloys over three years at Parker Dam on the ... to reduce the rate of mussel settlement, and any attached ...
... Calif. ( www.ucr.edu ) Research by Nosang ... Riverside, Bourns College of Engineering, has enabled a ... that can detect small quantities of harmful airborne ... Economy Corporation company, has completed the prototype which ...
Cached Biology News:Survival without water: A key trait of an aquatic invader to spread 2'Electronic nose' prototype developed 2
(Date:9/18/2014)... 18, 2014 HealthTronics, Inc ... interventional radiology products and services, announced that a ... and cryoablation) versus external beam radiotherapy (EBRT) is ... American Urological Association (MAAUA) Annual Meeting in Baltimore, ... Effectiveness of Cryosurgery and External Beam Radiation as ...
(Date:9/18/2014)... 2014  Health Enhancement Products, Inc. (OTCQB: HEPI), a ... compounds and metabolic processes, is pleased to announce the addition ... Ms. Nola E. Masterson , a California ... effective September 17, 2014. "We,re very pleased ... board," states Andrew Dahl , President and CEO. "She ...
(Date:9/18/2014)... DUBLIN , Sept. 18, 2014 ... the "Global and Chinese Stem Cell Industry Report, ... Stem cells are undifferentiated biological cells that can differentiate ... produce more stem cells. Stem cell therapy can be ... of hematological system disease), nervous system diseases, damage or ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Leatherwood ... FM-4910 listed material, to stay competitive in the ... These high-performance materials ultimately impact product quality and ... and owner. , Established in 1980 in Lewisville, ... as many fabricators have left the business. Much ...
Breaking Biology Technology:HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2
... 15, 2006, the Supreme Court in eBay Inc. v. ... proves infringement should be granted an injunction must be ... (1) irreparable injury; (2) inadequacy of remedies at law; ... The Court rejected the Federal Circuit's approach that an ...
... encounter, we reviewed the list of the leading Big Pharma companies of ... some of the leading pharmaceuticals products and deals of 2005. , ... Product/Company Disease Area ... Lipitor (Pfizer) Cholesterol Reduction $12.9 +6% ...
... Inc., a developer of protein chip technologies, has ... the National Institutes of Health to develop a test ... ,An estimated 50 million Americans suffer from mild to ... especially for children and senior citizens. GenTel's protein chips ...
Cached Biology Technology:Supreme Court decision in eBay case could affect value of patents 2Big Pharma's continued hunger and search for new products 2Big Pharma's continued hunger and search for new products 3Big Pharma's continued hunger and search for new products 4GenTel gets federal grant to develop allergy test 2GenTel gets federal grant to develop allergy test 3
RAT ANTI MOUSE F4/80 ANTIGEN:BIOTIN Immunogen: Thioglycollate stimulated peritoneal macrophages from C57/BL mice...
SHEEP ANTI FLECAINIDE...
ANTI PIG LDH H4...
RAT ANTI MOUSE F4/80 ANTIGEN:BIOTIN Immunogen: Thioglycollate stimulated peritoneal macrophages from C57/BL mice...
Biology Products: