Navigation Links
Discovery spotlights key role of mystery RNA modification in cells
Date:1/6/2014

the wrong pattern, you get disease."

It is well known that genetic factors can control protein expression, but the methylation and demethylation of RNA can be epigeneticoperating independent of the sequence of deoxyribonucleic acid (DNA). "This is a very important yet under-explored field," said Wang, the study's lead author and a graduate student in chemistry at UChicago. "It's also a field that is expanding very quickly."

Researchers had long known the presence of the m6A methylation on messenger RNA, but why this occurred remained unknown. He and his associates took a major step in 2011 when they discovered the reverse of the methylation process, demethylation. This discovery involved a so-called "eraser protein" that removed the methyl from RNA, a defect of which leads to obesity. "We basically said, 'Look, if you have certain defect of this function, you get obesity, so there's something going on fundamentally interesting. This methylation appears to play important roles in biological regulation."

He and his associates have now shown that the methylation affects the decay of messenger RNA. "People who are interested in messenger RNA decay or all kinds of cytoplasmic RNA biology now have a new pathway to consider," Wang said.

RNA methylation can vary anywhere from zero to 100 percent as needed to either fine-tune or globally affect protein production. "Researchers had realized that one way to tune the production of protein is to control the lifetime of messenger RNA," Wang said. "We discovered that reversible methylation could be an important parameter in regulating mRNA lifetime."

An extended RNA lifetime would result in more protein production. "If you have a defect of the demethylation mechanism, you could dramatically affect cellular protein levels," He said. And some of those proteins could be essential for energy regulation in the human body, which affects obesity. "Already we know obesity, diabetes and ferti
'/>"/>

Contact: Steve Koppes
skoppes@uchicago.edu
773-702-8366
University of Chicago
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Genetic discovery points the way to much bigger yields in tomato, other flowering food plants
2. Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery
3. Life Sciences Discovery Fund announces R&D grants
4. Chicago scientist involved in discovery of 4 new mammal species in Democratic Republic of Congo
5. U-M tinnitus discovery opens door to possible new treatment avenues
6. New discovery on how skin cells form bridges paves the way for advances in wound healing
7. Environment drives genetics in Evolution Canyon; discovery sheds light on climate change
8. CNIO study chosen as discovery of the year in regenerative medicine
9. Canadian researchers lead groundbreaking discovery in deadly childhood cancer
10. Surprising discovery: The skin communicates with the liver
11. Discovery of partial skeleton suggests ruggedly built, tree-climbing human ancestor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery spotlights key role of mystery RNA modification in cells
(Date:11/4/2014)... 2014   Neurotechnology , a provider of ... latest version of its fingerprint matching algorithm has ... evaluation organized by NIST. The MINEX test ... INCITS 378 fingerprint standard template format. MINEX compliance ... in the United States ...
(Date:11/3/2014)... birth weight and preterm birth are linked to increased ... published in the American College of Rheumatology (ACR) journal, ... birth weight and pre-term babies were not at greater ... , According to the ACR, 27 million Americans ... OA. Symptoms of OA range from mild to severe ...
(Date:11/2/2014)... and bump into a biologist . . . , While ... sketch, researchers have taken this premise and applied it to ... in the rising oceans of genomic data. , In this ... studies are publishing at a dizzying rate. The challenge is ... the noise (and there is no shortage of noise). , ...
Breaking Biology News(10 mins):Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3Preterm, low birth-weight babies may need new hips in adulthood 2Mutant models 2Mutant models 3Mutant models 4
... achieved dynamic, atomic-scale views of a protein needed to maintain ... work, funded in part by the National Institutes of Health, ... and a variety of other health conditions. Aquaporin proteins ... tissues, but aquaporin zero (AQP0) is found only in the ...
... 2013)Climate changes how species interact with one anotherand not just ... how climate change impacted the world in the ancient past ... in the future, according to a new study published in ... change has occurred repeatedly throughout Earth,s history, but the recent ...
... Children,s Research Hospital scientists have discovered a way to target ... without causing autoimmune problems. Researchers also found evidence that the ... today in the advance online edition of Nature . ... to develop immunotherapies to harness the immune system to fight ...
Cached Biology News:Researchers get close-up view of water pores needed in the eye's lens 2Researchers get close-up view of water pores needed in the eye's lens 3Looking to the past to predict the future of climate change 2Mechanism offers promising new approach for harnessing the immune system to fight cancer 2Mechanism offers promising new approach for harnessing the immune system to fight cancer 3
(Date:11/18/2014)... New Orleans, LA (PRWEB) November 17, 2014 ... developer of build-to-order, open architecture blade-based and rackmount ... new NVIDIA® Tesla® K80 dual-GPU accelerator throughout its ... Utilizing a pair of the company’s latest proprietary ... up to eight discrete NVIDIA Tesla K80 dual-GPU ...
(Date:11/18/2014)... 2014 Athena Signature Series: Turning Cancer ‘Off’ ... Emerson, a professor in the Regulatory Biology Laboratory at the ... discovery points to an “off switch” for drug resistance in ... her local research is making a global impact in the ... then join host Cheryl K. Goodman, CEO of Social Global ...
(Date:11/18/2014)... 18, 2014 American Process Inc. ... formed a partnership with researchers at Georgia Institute ... Technology, and the USDA’s Forest Products Laboratory to ... nanocellulose. Nanocellulose is a rapidly emerging high performance ... project is to replace heavy steel structures within ...
(Date:11/18/2014)... 18, 2014 2014 Deep ... is professional and in-depth report on Polytetrahydrofuran ... information, including its definition, characterization, application, and ... This exploration covers the worldwide business investigation, ... examination covering macroeconomic environment & financial circumstance ...
Breaking Biology Technology:Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 2Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 3American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 3PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 2PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 3
... in cat litter and other applications. The extraordinary properties of ... its scarcity in the Earth,s crust: only a few mines ... Spain, the world,s biggest exporter of this material. Sepiolite ... to filter and purify wine, but our understanding at the ...
... July 12, 2011 Life Technologies Corporation ... of innovative life science solutions, today introduced ... broad range of Swine Influenza Virus (SIV), a common ... significant weight loss resulting in economic loss to producers. ...
... July 11, 2011 The International Cancer Genome Consortium (ICGC) ... in Kyoto, Japan. The ICGC also announced that it is ... genomic data on more than 25,000 tumors for up to ... importance across the globe. "These new and ...
Cached Biology Technology:Cat litter to become an edible product? 2Life Technologies Introduces First and Only USDA-Approved Real-Time PCR Test to Detect Swine Influenza Virus 2Life Technologies Introduces First and Only USDA-Approved Real-Time PCR Test to Detect Swine Influenza Virus 3ICGC Releases New Genomic Data on Cancer Ahead of Schedule 2ICGC Releases New Genomic Data on Cancer Ahead of Schedule 3ICGC Releases New Genomic Data on Cancer Ahead of Schedule 4ICGC Releases New Genomic Data on Cancer Ahead of Schedule 5
... For use in hybridization incubators ... and GL 45 size PP plug-seal ... seal. Available in three lengths to ... plug-seal caps and O-rings available separately. ...
... efficient extraction of DNA from agarose gels The ... fragments of 150 bp to > 12,000 bp in ... to dissolve the gel slice, followed by adsorption of ... column format. After a wash step, the purified DNA ...
Fujifilm BAS-1800II provides the ideal configuration for a low-cost imager that requires only a small amount of space in the laboratory. The small imager for accurate high-throughput screening...
When added to StemSep T Cell Enrichment cocktail, human TCRab TAC is designed to deplete human TCRab from samples to isolate gd T cells....
Biology Products: