Navigation Links
Discovery spotlights key role of mystery RNA modification in cells
Date:1/6/2014

Researchers had known for several decades that a certain chemical modification exists on messenger ribonucleic acid (mRNA), which is essential to the flow of genetic information. But only recently did experiments at the University of Chicago show that one major function of this modification governs the longevity and decay of RNA, a process critical to the development of healthy cells.

The chemical modification on mRNA in question is called N6-methyladenosine (m6A). A recent study by UChicago scientists reveals how the m6A modification on mRNA could affect the half life of mRNA that in turn regulates cellular protein quantities That discovery could provide fundamental insights into healthy functioning and disorders such as obesity, diabetes, and infertility.

The m6A modification "affects a huge number of messenger RNA in human cells, and yet we did not know its exact function," said Chuan He, professor in chemistry at UChicago and a recently selected investigator of the Howard Hughes Medical Institute. He, Xiao Wang and 11 co-authors from UChicago, University of California, San Diego, and Peking University reported their findings on m6A in the Jan. 2 issue of Nature.

RNA in human cells becomes constantly depleted as it produces proteins, an instability that is essential to biology. "Whenever a cells starts to differentiate, transform into a different type of cell, it needs to express a different set of proteins using a different set of messenger RNA," He said. "It can't be the original set."

The disposal of old RNA allows for the addition of new RNA and the production of different proteins. The Nature study documents that this process is regulated by the insertion or removal of a methyl, a chemical group commonly found in organic compounds.

"Biology is about protein expression regulation: which proteins, how many and at what point," He explained. "If you have the right pattern you get healthy cells. If you get
'/>"/>

Contact: Steve Koppes
skoppes@uchicago.edu
773-702-8366
University of Chicago
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Genetic discovery points the way to much bigger yields in tomato, other flowering food plants
2. Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery
3. Life Sciences Discovery Fund announces R&D grants
4. Chicago scientist involved in discovery of 4 new mammal species in Democratic Republic of Congo
5. U-M tinnitus discovery opens door to possible new treatment avenues
6. New discovery on how skin cells form bridges paves the way for advances in wound healing
7. Environment drives genetics in Evolution Canyon; discovery sheds light on climate change
8. CNIO study chosen as discovery of the year in regenerative medicine
9. Canadian researchers lead groundbreaking discovery in deadly childhood cancer
10. Surprising discovery: The skin communicates with the liver
11. Discovery of partial skeleton suggests ruggedly built, tree-climbing human ancestor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery spotlights key role of mystery RNA modification in cells
(Date:9/21/2014)... what was previously thought, newborn immune T cells may ... bacteria, according to a new study led by King,s ... to that of adults, babies may still be able ... published in the journal Nature Medicine . , ... types of immune cells, including neutrophils which play an ...
(Date:9/21/2014)... a protein therapy that disrupts the process that causes ... travel through the blood stream and start aggressive new ... as metastasis, can cause cancer to spread with deadly ... to cancer fall prey to metastatic forms of the ... who describes a new therapeutic approach in Nature ...
(Date:9/19/2014)... by researchers from several Harvard University labs in ... and aspiring researchers with the intellectual raw materials ... from soft, flexible materials. , With the advent ... advances in manufacturing technology, soft robotics is emerging ... from conventional rigid robot design, but working with ...
Breaking Biology News(10 mins):Immune system of newborn babies is stronger than previously thought 2Stanford researchers create 'evolved' protein that may stop cancer from spreading 2Stanford researchers create 'evolved' protein that may stop cancer from spreading 3Stanford researchers create 'evolved' protein that may stop cancer from spreading 4Soft robotics 'toolkit' features everything a robot-maker needs 2
... - A study comparing a University of Pennsylvania ... to the traditional American method has shown that 80 ... traditional method are actually at risk for developing osteoarthritis ... The results indicate that traditional scoring of radiographs that ...
... most established fisheries certifier is failing on its promises ... leading fisheries experts from the University of British Columbia ... California at San Diego and elsewhere. Established in ... of the world,s largest fish retailers, the Marine Stewardship ...
... but estrogen might not be the reason. Testosterone, though, could ... the lab of Florida State University researcher Mohamed Kabbaj, associate ... a five-year, $1.8 million grant from the National Institute of ... research team also is working to identify the role of ...
Cached Biology News:Hip dysplasia susceptibility in dogs may be underreported, according to Penn Vet comparative study 2Hip dysplasia susceptibility in dogs may be underreported, according to Penn Vet comparative study 3Hip dysplasia susceptibility in dogs may be underreported, according to Penn Vet comparative study 4Seafood stewardship questionable: UBC-Scripps experts 2Seafood stewardship questionable: UBC-Scripps experts 3Why does anxiety target women more? FSU researcher awarded $1.8 million grant to find out 2
(Date:9/19/2014)... -- Dublin ... the addition of the  "Micro Market Monitor : ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , ,The ... segments in the chromatography market. The market was ... to reach $2.0 billion by 2019, at a ...
(Date:9/19/2014)... LONDON , September 19, 2014 ... Spain , available today on PharmaBoardroom.com ... of the Eurozone crisis that rocked the Spanish economy in ... the Spanish pharma community has remained pragmatic in times of ... is still the fifth biggest European market, and the ...
(Date:9/18/2014)... HealthTronics, Inc ., a leading ... and services, announced that a poster related to ... external beam radiotherapy (EBRT) is being presented at ... (MAAUA) Annual Meeting in Baltimore, Maryland September 18-21, ... and External Beam Radiation as Treatments for Localized ...
(Date:9/18/2014)... 2014 /PRNewswire-iReach/ -- DeepResearchReports.com adds "2014 Deep Research ... and "2014 Deep Research Report on Global and ... database. Photo - http://photos.prnewswire.com/prnh/20140918/147058 ... Global and China Acetic Acid Industry" is a ... China and Global Acetic Acid Market. ...
Breaking Biology Technology:Micro Market Monitor : Global Pre-packed Chromatography Columns 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 4
... body, then alarm bells start ringing. Such clumps, ... type 2 diabetes, formerly called adult-onset diabetes. If ... might be able to treat such diseases more efficiently. ... the Helmholtz-Zentrum Dresden-Rossendorf and the university in Aarhus, Denmark, ...
... The Plasma Protein Therapeutics Association (PPTA) applauds the ... Drugs Act ( H.R. 2672 ) and ( S. ... therapies that treat patients with rare diseases by eliminating barriers ... on plasma protein therapies are coping with a very rare ...
... (NASDAQ: GPRO ) today reported financial results for ... million and non-GAAP earnings per share (EPS) of $0.51.   ... products in the second quarter of 2011, while supply chain ... sales a year ago," said Carl Hull, the Company,s president ...
Cached Biology Technology:In the pursuit of dangerous clumps 2In the pursuit of dangerous clumps 3PPTA Praises Legislation That Protects the Treatment of Rare Diseases 2Gen-Probe Reports Financial Results for the Second Quarter of 2011 2Gen-Probe Reports Financial Results for the Second Quarter of 2011 3Gen-Probe Reports Financial Results for the Second Quarter of 2011 4Gen-Probe Reports Financial Results for the Second Quarter of 2011 5Gen-Probe Reports Financial Results for the Second Quarter of 2011 6Gen-Probe Reports Financial Results for the Second Quarter of 2011 7Gen-Probe Reports Financial Results for the Second Quarter of 2011 8Gen-Probe Reports Financial Results for the Second Quarter of 2011 9Gen-Probe Reports Financial Results for the Second Quarter of 2011 10Gen-Probe Reports Financial Results for the Second Quarter of 2011 11Gen-Probe Reports Financial Results for the Second Quarter of 2011 12Gen-Probe Reports Financial Results for the Second Quarter of 2011 13Gen-Probe Reports Financial Results for the Second Quarter of 2011 14
UltraPure DNase/RNase-Free Distilled Water is designed for use in all molecular biology applications. It is 0.1-m membrane-filtered and tested for DNase and RNase activity....
...
Water Distilled (Gibco™) is membrane filtered and endotoxin screened....
Immunogen: Human Respiratory Syncytial Virus (RSV) and Bovine Respiratory Syncytial Virus (BRSV) Fusion protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: