Navigation Links
Discovery spotlights key role of mystery RNA modification in cells
Date:1/6/2014

Researchers had known for several decades that a certain chemical modification exists on messenger ribonucleic acid (mRNA), which is essential to the flow of genetic information. But only recently did experiments at the University of Chicago show that one major function of this modification governs the longevity and decay of RNA, a process critical to the development of healthy cells.

The chemical modification on mRNA in question is called N6-methyladenosine (m6A). A recent study by UChicago scientists reveals how the m6A modification on mRNA could affect the half life of mRNA that in turn regulates cellular protein quantities That discovery could provide fundamental insights into healthy functioning and disorders such as obesity, diabetes, and infertility.

The m6A modification "affects a huge number of messenger RNA in human cells, and yet we did not know its exact function," said Chuan He, professor in chemistry at UChicago and a recently selected investigator of the Howard Hughes Medical Institute. He, Xiao Wang and 11 co-authors from UChicago, University of California, San Diego, and Peking University reported their findings on m6A in the Jan. 2 issue of Nature.

RNA in human cells becomes constantly depleted as it produces proteins, an instability that is essential to biology. "Whenever a cells starts to differentiate, transform into a different type of cell, it needs to express a different set of proteins using a different set of messenger RNA," He said. "It can't be the original set."

The disposal of old RNA allows for the addition of new RNA and the production of different proteins. The Nature study documents that this process is regulated by the insertion or removal of a methyl, a chemical group commonly found in organic compounds.

"Biology is about protein expression regulation: which proteins, how many and at what point," He explained. "If you have the right pattern you get healthy cells. If you get
'/>"/>

Contact: Steve Koppes
skoppes@uchicago.edu
773-702-8366
University of Chicago
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Genetic discovery points the way to much bigger yields in tomato, other flowering food plants
2. Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery
3. Life Sciences Discovery Fund announces R&D grants
4. Chicago scientist involved in discovery of 4 new mammal species in Democratic Republic of Congo
5. U-M tinnitus discovery opens door to possible new treatment avenues
6. New discovery on how skin cells form bridges paves the way for advances in wound healing
7. Environment drives genetics in Evolution Canyon; discovery sheds light on climate change
8. CNIO study chosen as discovery of the year in regenerative medicine
9. Canadian researchers lead groundbreaking discovery in deadly childhood cancer
10. Surprising discovery: The skin communicates with the liver
11. Discovery of partial skeleton suggests ruggedly built, tree-climbing human ancestor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery spotlights key role of mystery RNA modification in cells
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced ... (GCP) audit to confirm its adherence to current ... accomplishment enables HITLAB to conduct regulated smart device ... principles for patient safety and research quality. ... access, quality, and delivery with innovative technology," said ...
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ... "Global Chemical Sensor Market 2015-2019" report to ... One major trend upcoming in ... sensors in biomedical applications. Chemical sensors help in ... diagnosis during surgical procedures. The Global Chemical Sensor ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research ... announced the addition of the "Global Facial ... http://photos.prnewswire.com/prnh/20130307/600769 ... the identification of individuals. Facial recognition system measures ... as nose, jaw edges, mouth, and the distance ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... have found that melatonin, a naturally occurring brain substance, ... as seasonal affective disorder, or SAD. The study is ... National Academy of Science. , The study was led ... in the study of circadian (24-hour) rhythm disturbances, such ...
... and infects the most common and deadly form of brain ... devour themselves, researchers at The University of Texas M. D. ... the National Cancer Institute. , The modified adenovirus homed in ... among the cancer cells -- a process called autophagy -- ...
... the neural machinery that triggers the hungry brain to ... swings the other way after a hearty meal, as ... siesta. However, scientists have understood little about how the ... energy-related behaviors. , Now, in an article in the ...
Cached Biology News:Melatonin improves mood in winter depression 2Targeted virus compels cancer cells to eat themselves 2Targeted virus compels cancer cells to eat themselves 3New mechanism explains glucose effect on wakefulness 2New mechanism explains glucose effect on wakefulness 3
(Date:12/24/2014)... “Preparative & Process Chromatography Market by Instrument ... Buffers, Valves, Guages, Seals), Accessories, Services, End User ... 2019” provides a detailed overview of the major ... strategies impacting the preparative and process chromatography market ... revenue and share analysis. , Full Copy ...
(Date:12/24/2014)... Bethesda, MD (PRWEB) December 23, 2014 ... signed into law H.R. 83, the Omnibus and ... the first time, made hydrocephalus a condition eligible ... Research Programs (CDMRP) administered by the Department of ... conjunction with its allies on Capitol Hill, is ...
(Date:12/24/2014)... The report expects global cell isolation and expansion market ... a carefully analyzed data about the vital drivers, restraints, ... Full Copy of Report @ http://bit.ly/1yUxy0T , ... expansion will keep witnessing growth at an impressive CAGR ... driven by rapid technological advancements, government funding and investments, ...
(Date:12/24/2014)... December 23, 2014 PharmaBoardroom,s ... out today and available for free download , digs ... change and growth in the sector today. One ... successes has been in developing a homegrown pharmaceutical manufacturing base, ... production still remains some way off. A cursory comparison with ...
Breaking Biology Technology:Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3
... America,s war on terror includes fighting the dark ... chemist Dr. Frank Raushel is helping with the fight ... chemical agent, the organophosphates. , Synthetic organophosphates started their ... their way into the dangerous alleys of chemical warfare ...
... away, but soccer aficionados can get an early start ... National Institute of Standards and Technology (NIST) and the ... summer. , Nanosoccerthe Lilliputian competition where computer-driven "nanobots" the ... no bigger than a grain of ricewill be part ...
... SAN DIEGO, Nov. 13 Gen-Probe Incorporated,(Nasdaq: GPRO ... the Lazard,Capital Markets 5th Annual Healthcare Conference on Tuesday, ... presentation is scheduled,to be webcast live and may be ... website at http://www.gen-probe.com . The webcast,will be available ...
Cached Biology Technology:Researcher working on destruction of chemical weapons 2Let the games begin! Nanosoccer at 2009 RoboCup in Austria 2Gen-Probe to Webcast Presentation at the Lazard Capital Markets 5th Annual Healthcare Conference 2
For removal of the zona pellucida. Sterile, Mouse Embryo tested...
... linear ion trap mass spectrometer enables high-throughput ... The LXQ linear ion trap mass spectrometer ... applications, delivering the fast cycle time and ... trap at an attractive price. The ...
... enables scientists who do not have access to ... have their biological samples tested for the concentration ... as 1-2-3 Chose the analytes you ... the S&S antibody menu. Send your samples ...
... 2) Dot plot, Contour plot, Density ... 4) Cell Cycle 5) Analysis ... batch generation of graphs and statistics 8) ... operations to perform complex batch analyses 10) ...
Biology Products: