Navigation Links
Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
Date:3/19/2012

Chemists at the University of California, San Diego have produced the first high resolution structure of a molecule that when attached to the genetic material of the hepatitis C virus prevents it from reproducing.

Hepatitis C is a chronic infectious disease that affects some 170 million people worldwide and causes chronic liver disease and liver cancer. According to the Centers for Disease Control and Prevention, hepatitis C now kills more Americans each year than HIV.

The structure of the molecule, which was published in a paper in this week's early online edition of the journal Proceedings of the National Academy of Sciences, provides a detailed blueprint for the design of drugs that can inhibit the replication of the hepatitis C virus, which proliferates by hijacking the cellular machinery in humans to manufacture duplicate viral particles.

Finding a way to stop that process could effectively treat viral infections of hepatitis C, for which no vaccine is currently available. But until now scientists have identified few inhibiting compounds that directly act on the virus's ribonucleic acid (RNA) genomethe organism's full complement of genetic material.

"This lack of detailed information on how inhibitors lock onto the viral genome target has hampered the development of better drugs," said Thomas Hermann, an associate professor of chemistry and biochemistry at UC San Diego who headed the research team, which also included scientists from San Diego State University. The team detailed the structure of a molecule that induces the viral RNA to open up a portion of its hinge-like structure and encapsulate the inhibitor like a perfectly fit glove, blocking the ability of the hepatitis C virus to replicate.

The molecule is from a class of compounds called benzimidazoles, known to stop the production of viral proteins in infected human cells. Its three-dimensional atomic structure was determined by X-ray crystallogra
'/>"/>

Contact: Kim McDonald
kmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related biology news :

1. Annual Drug Discovery Conferences Being Held in Boston MA, Spring 2012
2. Discovery of a molecule that initiates maturation of mammalian eggs can lead to more IVF pregnancies
3. A*STAR scientists make groundbreaking discovery on stem cell regulation
4. A biodiversity discovery that was waiting in the wings -- wasp wings, that is
5. OHSU discovery may someday lead to prevention and treatment of sudden infant death syndrome
6. Notre Dame researchers report fundamental malaria discovery
7. Discovery of plant nourishing gene brings hope for increased crop seed yield and food security
8. Discovery could help stem smoking-related diseases
9. Georgetown researchers lead discovery expected to significantly change biomedical research
10. New horned dinosaur announced nearly 100 years after discovery
11. Researchers awarded $3.2 million from NIH to pioneer advanced biomolecule discovery technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... addition of the "iPhone 5S Fingerprint Sensor ... report to their offering. ... acquisition of AuthenTec in July 2012, Apple introduced ... It is currently the only device of Apple ...
(Date:12/19/2014)... 18, 2014  23andMe, Inc., the leading personal genetics ... pinpoints fine-scale differences in genetic ancestry of individuals from ... Since immigrants first arrived more than four hundred ... has served as a meeting place for peoples from ... the ongoing mixing of peoples with African, European, and ...
(Date:12/17/2014)... , Dec. 15, 2014 Research and Markets ... addition of the "Samsung Galaxy S5 - ... report to their offering. ... totally different sensing technology than the iPhone 5S, ... sensor in its product. The Galaxy ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... EUGENE, Ore.(Aug. 20, 2007)Nitric acid is a notoriously strong and ... our atmosphere. However, a team of researchers have found that ... top of a water surface. The discovery of the ... the surface of water requires us to re-evaluate how we ...
... of G&D, Drs. Maria Divina Deato and Robert Tjian ... alternative transcriptional core promoter complex directs cell-type specific differentiation ... of transcriptional control of terminal cell differentiation, and will ... date at www.genesdev.org . For nearly 30 ...
... after prior full-dose conventional radiation therapy respond to Boron ... a Phase I/II study at the Helsinki University Hospital, ... Heikki Joensuu, University of Helsinki, considers the results ... field for BNCT, since thus far BNCT has been ...
Cached Biology News:University of Oregon researcher finds that on water's surface, nitric acid is not so tough 2A new radiation therapy treatment developed for head and neck cancer patients 2
(Date:12/24/2014)... “Preparative & Process Chromatography Market ... (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, ... Forecasts to 2019” provides a detailed overview of ... trends, and strategies impacting the preparative and process ... of the revenue and share analysis. , ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... series is designed to introduce cutting edge ... users and partners of platform upgrades. This ... benefits; empowering users in their quest to ... tools. , According to SoundConnect’s Marketing Manager, ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... mercaptan such as its definition, classification, application ... product specification, manufacturing process, and product cost ... and applications. The analysis also covers upstream ... channels, industry development trend and proposals. In ...
(Date:12/24/2014)... Pipette.com announces their Holiday in ... submit their #HolidayInTheLab pictures for a chance to win ... For those struggling to think of a holiday gift ... the Lab Contest provides the ideal holiday presents. The ... send pictures of their chemistree, holiday sweaters, as well ...
Breaking Biology Technology:Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2
... , CAMBRIDGE, Mass. , April 28 ... Research Awards Program.  Given annually, the awards will fund ... of diseases and other important human traits. To inaugurate ... interpretation services to three winning research groups, each of ...
... ... browsers enable researchers to quickly and effectively use these invaluable resources. , ... Seattle, WA (PRWEB) April 26, 2010 -- OpenHelix ... on the Overview of Genome Browsers. , , , Ensembl is a genome browser ...
... , LELYSTAD and ,S-HERTOGENBOSCH, The Netherlands ... based biotechnology firm focusing on,protein mimicking technology for the generation of ... therapeutic vaccine,portfolio with Immunovo BV of ,s-Hertogenbosch. Under the terms of ... a,minority interest in Immunovo. , ...
Cached Biology Technology:Knome Announces KnomeDISCOVERY Research Awards Program 2New and Updated Online Tutorials for Ensembl Legacy and Overview of Genome Browsers 2New and Updated Online Tutorials for Ensembl Legacy and Overview of Genome Browsers 3Pepscan Signs Partnering Agreement With Immunovo for its Therapeutic Vaccine Portfolio 2Pepscan Signs Partnering Agreement With Immunovo for its Therapeutic Vaccine Portfolio 3
... versatile enclosures are designed ... or other process gas ... environment. HEPA filtration, heating/cooling, ... modules also available, along ...
... researcher, the new 4300 DNA Analysis System from ... quality of your data. High confidence in more ... LI-COR DNA analysis systems have had for more ... third generation instrument based on LI-CORs highly sensitive ...
... isolation chamber provides a safe, clean ... pharmaceuticals, in accord with USP-797 requirements. ... (ISO 5) cleanliness conditions in the ... rod and tilt-up front panel for ...
... siRNA Tracker Intracellular Localization Kit with ... forward approach to directly label and ... an efficient yet non-destructive manner, for ... and functional inhibition of target gene ...
Biology Products: