Navigation Links
Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
Date:3/19/2012

Chemists at the University of California, San Diego have produced the first high resolution structure of a molecule that when attached to the genetic material of the hepatitis C virus prevents it from reproducing.

Hepatitis C is a chronic infectious disease that affects some 170 million people worldwide and causes chronic liver disease and liver cancer. According to the Centers for Disease Control and Prevention, hepatitis C now kills more Americans each year than HIV.

The structure of the molecule, which was published in a paper in this week's early online edition of the journal Proceedings of the National Academy of Sciences, provides a detailed blueprint for the design of drugs that can inhibit the replication of the hepatitis C virus, which proliferates by hijacking the cellular machinery in humans to manufacture duplicate viral particles.

Finding a way to stop that process could effectively treat viral infections of hepatitis C, for which no vaccine is currently available. But until now scientists have identified few inhibiting compounds that directly act on the virus's ribonucleic acid (RNA) genomethe organism's full complement of genetic material.

"This lack of detailed information on how inhibitors lock onto the viral genome target has hampered the development of better drugs," said Thomas Hermann, an associate professor of chemistry and biochemistry at UC San Diego who headed the research team, which also included scientists from San Diego State University. The team detailed the structure of a molecule that induces the viral RNA to open up a portion of its hinge-like structure and encapsulate the inhibitor like a perfectly fit glove, blocking the ability of the hepatitis C virus to replicate.

The molecule is from a class of compounds called benzimidazoles, known to stop the production of viral proteins in infected human cells. Its three-dimensional atomic structure was determined by X-ray crystallogra
'/>"/>

Contact: Kim McDonald
kmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related biology news :

1. Annual Drug Discovery Conferences Being Held in Boston MA, Spring 2012
2. Discovery of a molecule that initiates maturation of mammalian eggs can lead to more IVF pregnancies
3. A*STAR scientists make groundbreaking discovery on stem cell regulation
4. A biodiversity discovery that was waiting in the wings -- wasp wings, that is
5. OHSU discovery may someday lead to prevention and treatment of sudden infant death syndrome
6. Notre Dame researchers report fundamental malaria discovery
7. Discovery of plant nourishing gene brings hope for increased crop seed yield and food security
8. Discovery could help stem smoking-related diseases
9. Georgetown researchers lead discovery expected to significantly change biomedical research
10. New horned dinosaur announced nearly 100 years after discovery
11. Researchers awarded $3.2 million from NIH to pioneer advanced biomolecule discovery technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... , March 23, 2015  In the 2014 ... fraud case conviction losses. This figure accounts for a ... according to The Nilson Report, exceeds $11 billion globally. ... tool after a crime has occurred. Investor Mark ... polygraph expert Joe Paolella partnered to administer ...
(Date:3/20/2015)... Conn. , March 20, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... smart wallet is one of the products featured in ... March 20th at 11:00 PM EST on the DIY ... to Las Vegas , site of ...
(Date:3/17/2015)... 2015 MedNet Solutions , a ... study management systems, is pleased to announce that ... Outsourcing in Clinical Trials Southeast conference – March ... excellent forum for MedNet to showcase iMedNet ... (SaaS) eClinical technology platform. We strongly ...
Breaking Biology News(10 mins):Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2
... have modified a human embryonic stem cell (hESC) line to ... The modified hESC line, ErythRED, represents a major ... functional red blood cells from human embryonic stem cells. ... Andrew Elefanty and Ed Stanley at the Monash Immunology and ...
... Champalimaud Neuroscience Programme at the Instituto Gulbenkian de Ciencia ... of the prestigious European Research Council Starting grants, out ... flagship award scheme. The grant, totalling close to 1.6 ... allow Rui Costa,s young research team to pursue their ...
... U.S.A. A cellular molecule that not only can sense ... mount a defense has been identified by microbiologists at The ... The finding, published online Sunday, Aug. 23, by the journal ... human respiratory syncytial virus (RSV) and influenza A (commonly known ...
Cached Biology News:IGC scientist awarded prestigious European Research Council Starting grant 2Microbiologists find defense molecule that senses respiratory viruses 2
(Date:3/27/2015)... 2015  Peter Walter wurde als Gewinner ... seine bahnbrechende Arbeit ausgewählt, die sich damit ... sowie für die Entschlüsselung der Komponenten eines ... nutzen, der mit der Ansammlung von deformierten ... Biochemie an der University of California, San ...
(Date:3/27/2015)... NEW YORK , March 27, 2015  Peter ... in Biomedical Science for his pioneering work on how ... the components of a regulatory mechanism that cells use ... proteins. Dr. Walter is a professor of biochemistry at ... the groundwork for treating a range of human diseases ...
(Date:3/27/2015)... March 27, 2015  CASI Pharmaceuticals, Inc. (Nasdaq: ... development and commercialization of innovative therapeutics addressing cancer and ... a commercial focus on China , ... months ended December 31, 2014.  The ... ($0.05) per share, for the three months ended December ...
(Date:3/26/2015)... PRC Clinical, a Silicon-Valley based ... and executive appointments effective immediately. , Mike Catelani will ... member of the Board of Directors. Daniel Head is ... Dowden will assume the position of Senior Director of ... Officer (COO), has been appointed to the position of ...
Breaking Biology Technology:Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 3Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 4German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 3CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 2CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 3CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 4CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 5CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 6PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 2PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 3
... organic,growth continued in Q2 2008 supported by new research product ... profiling remains on track for year end launch., ... year-earlier period to DKK 28 million, totaling DKK 44.5 ... Product sales in Q2 2008 increased by 239% on the ...
... inspired by historic,Philadelphia, Pa. and revel in the ... room rate while you discover best practices and ... Hewlett-Packard,Johnson & Johnson, Motorola, Nortel, Roche, Sanofi-Aventis and ... Excellence Conference: How Process,Improvement Leaders Produce Profits in ...
... 28 Students attending US,colleges that require tuberculosis ... (IGRA) such as QuantiFERON(R)-TB Gold,(QFT(TM)), with the release ... Health Association (ACHA). In the past, students would,have ... which is known to,suffer from false-positive results due ...
Cached Biology Technology:Exiqon A/S: Interim Report for the Period 1 January - 30 June 2008 (Unaudited) 2Early-Bird Registration Ends this Week for 10th Annual Quality Excellence Conference: How Process Improvement Leaders Produce Profits in Recessions 2US College Students Needing TB Testing Now Have the Benefit of QFT(TM) 2US College Students Needing TB Testing Now Have the Benefit of QFT(TM) 3
ImageQuant 400, 1 EA. Category: ImageQuant CCD Imagers....
ImageQuant 100 UV, 1 EA. Category: ImageQuant CCD Imagers....
IMAGEQUANT 300 IQTL, 1 EA. Category: ImageQuant CCD Imagers....
Recombinant Rat PTX2/SAP...
Biology Products: