Navigation Links
Discovery points to new approach for diabetes therapy
Date:7/12/2010

CORVALLIS, Ore. Nutrition experts at Oregon State University have essentially "cured" laboratory mice of mild, diet-induced diabetes by stimulating the production of a particular enzyme.

The findings could offer a new approach to diabetes therapy, experts say, especially if a drug could be identified that would do the same thing, which in this case was accomplished with genetic manipulation.

Increased levels of this enzyme, called fatty acid elongase-5, restored normal function to diseased livers in mice, restored normal levels of blood glucose and insulin, and effectively corrected the risk factors incurred with diet-induced diabetes.

"This effect was fairly remarkable and not anticipated," said Donald Jump, a professor of nutrition and exercise sciences at Oregon State, where he is an expert on lipid metabolism and principal investigator with OSU's Linus Pauling Institute.

"It doesn't provide a therapy yet, but could be fairly important if we can find a drug to raise levels of this enzyme," Jump said. "There are already some drugs on the market that do this to a point, and further research in the field would be merited."

The studies were done on a family of enzymes called "fatty acid elongases," which have been known of for decades. Humans get essential fatty acids that they cannot naturally make from certain foods in their diet. These essential fatty acids are converted to longer and more unsaturated fatty acids. The fatty acid end products of these reactions are important for managing metabolism, inflammation, cognitive function, cardiovascular health, reproduction, vision and other metabolic roles.

The enzymes that do this are called fatty acid elongases, and much has been learned in recent years about them. In research on diet-induced obesity and diabetes, OSU studied enzyme conversion pathways, and found that elongase-5 was often impaired in mice with elevated insulin levels and diet-induced obesity
'/>"/>

Contact: Donald Jump
donald.jump@oregonstate.edu
541-737-4007
Oregon State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. DNA discovery opens new door to develop tools, therapies for hereditary cancers
2. Discovery of a hepatitis C-related virus in bats may reduce outbreaks in humans
3. Discovery of how coral reefs adapt to global warming could aid reef restoration
4. Discovery of controlled swarm in bacteria
5. Molecular discovery suggests new strategy to fight cancer drug resistance
6. New discovery could aid development of elusive bovine mastitis vaccine
7. Medical researchers discovery may explain how certain cancers develop
8. Discovery may lead to safer drinking water, cheaper medicine: Queens University researchers
9. Discovery: Yeast make plant hormone that speeds infection
10. Discovery of stem cell illuminates human brain evolution, points to therapies
11. Covance Establishes New Discovery & Translational Services Group
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... the human retinoblastoma protein gene are a leading cause ... turned to fruit fly eyes to unlock the secrets ... paper featured on the cover of the current issue ... State University researchers provide the first detailed examination of ... the human cancer gene, said Irina Pushel, MSU undergraduate ...
(Date:9/17/2014)... decline, grasses have returned to some once-denuded patches of ... those places seems healthy again, but a new study ... coastal protection remains diminished. , "We,ve got ... back," said ecologist Mark Bertness, professor of biology at ... journal Biological Conservation . "The metric of a ...
(Date:9/17/2014)... a great deal about complex social behavior by studying ... to teach too. , With their unusually large brains ... live in a complex social environment---not merely in a ... ants, but in a dynamic setting of alliances and ... mammals: dolphins, whales, primates, and social carnivores, like hyenas ...
Breaking Biology News(10 mins):Abnormal properties of cancer protein revealed in fly eyes 2Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3Being social: Learning from the behavior of birds 2
... life on earth, yet freshwater animals and plants are ... The dominant causes are the many stressors that affect ... by alien species, dams, over-abstraction, many forms of pollution ... sensitive to climate change which now exacerbates all these ...
... in the September 2008 issue of BioScience ... and Its Use in Basic and Applied Insect Science. ... genomes and comparative genomics are providing new insights into ... to a variety of biotechnological applications to pest management, ...
... have been diagnosed with Parkinson,s disease, could benefit from ... Craig from Queen,s School of Psychology is researching the ... have difficulty controlling their movements. The work is ... European Research Council. Dr Craig is the only ...
Cached Biology News:Water: stressed-out and overheated 2BioScience tip sheet, September 2008 2New sensory devices will aid Parkinson's and stroke patients 2
(Date:9/17/2014)... 17, 2014 Veracyte, Inc. (Nasdaq: ... the field of molecular cytology, today announced the promotion ... Mr. Hall joined Veracyte in 2010 as chief ... endocrinology. Since 2012, he has led sales, marketing, laboratory ... and billing functions. As chief operating officer, Mr. Hall ...
(Date:9/17/2014)... GLASGOW, Scotland , September 17, 2014 ... a new mode of action from a ... a decade  MGB Biopharma, a ... of anti-infectives, announces today that it has ... of its lead antibacterial, MGB-BP-3, against a ...
(Date:9/16/2014)... -- This report analyzes the worldwide markets for Bioinformatics in ... Biocontent. The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the period 2013 ... these markets. Market data and analytics are derived from primary ...
(Date:9/16/2014)... University scientists who created a deicing film for radar ... a transparent coating for glass. , The new ... could keep glass surfaces from windshields to skyscrapers free ... radio frequencies (RF). , The technology was introduced ... Applied Materials and Interfaces . , The material ...
Breaking Biology Technology:Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 2Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 3Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 4MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 2MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 3MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 4MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 5MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 6MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 7Global Bioinformatics Industry 2Global Bioinformatics Industry 3Global Bioinformatics Industry 4Global Bioinformatics Industry 5Global Bioinformatics Industry 6Global Bioinformatics Industry 7Global Bioinformatics Industry 8Global Bioinformatics Industry 9Global Bioinformatics Industry 10Global Bioinformatics Industry 11Global Bioinformatics Industry 12Global Bioinformatics Industry 13Global Bioinformatics Industry 14Global Bioinformatics Industry 15Global Bioinformatics Industry 16Global Bioinformatics Industry 17Global Bioinformatics Industry 18Global Bioinformatics Industry 19Global Bioinformatics Industry 20Global Bioinformatics Industry 21Global Bioinformatics Industry 22Global Bioinformatics Industry 23Nanoribbon film keeps glass ice-free 2
... The Netherlands, September 26 A consortium of,experts in ... have,joined forces to develop a novel pandemic influenza vaccine ... awarded a grant of,EUR3.5 million from the European Union ... new vaccine. The so-called FluVac project will be,coordinated by ...
... Glycominds Ltd., a biodiagnostics,company specializing in glycan biomarkers ... cancer, announced today that has,entered the Biomolecular Photonic ... the Government of Israel to improve in-vivo imaging ... BMP consortium was,approved for three years and was ...
... NanoBio(R) Corporation, a,biopharmaceutical company developing novel anti-infective topicals ... today announced,the addition of four new scientists to ... Ph.D.; Susan Ciotti, Ph.D.; Robert L. Hagan, Ph.D.,and ... and commercializing,its novel topical anti-infectives and mucosal vaccines. ...
Cached Biology Technology:European Expert Consortium Combines Forces to Develop a Novel Pandemic Influenza Vaccine 2European Expert Consortium Combines Forces to Develop a Novel Pandemic Influenza Vaccine 3Glycominds Joins Biomolecular Photonic (BMP) Consortium to Develop New Molecular Imaging Technique 2NanoBio Expands Drug Development Team for Its Anti-Infective Products 2NanoBio Expands Drug Development Team for Its Anti-Infective Products 3
... I-96 Plate can be used either in ... large-scale (i.e., 96-well) purification of DNA and/or ... unique silica-based matrix make it perfect for ... RNA in = 10 l eluate per ...
AdestaTM Tissue/Cell Preservation Medium Sterile / Non-sterile: Sterility Tested Endotoxin: ...
... is the first all-inclusive collection of key ... Expression System. Methods developed by the leaders ... step-by-step protocols. This book will guide you ... strain construction and analysis, to production of ...
Rad 51C Immunogen: His-tagged human Rad 51C, over-expressed in E. coli Storage: 4 C...
Biology Products: