Navigation Links
Discovery of therapeutic peptides affecting mitochondria
Date:11/9/2011

In 2010, after more than 10 years of basic research, Dr. Peter W. Schiller, a world-renowned peptide chemist and Director of the Chemical Biology and Peptide research unit at the Institut de recherches cliniques de Montral (IRCM), and his international collaborators were the listed inventors on two U.S. patents awarded to the institute and covering different uses of a unique class of peptide compounds initially synthesized in Dr. Schiller's laboratory at the IRCM.

A total of five U.S. patents have been awarded to the IRCM to date involving these new peptide compounds. Patent applications have also been filed in many other countries, including Canada, Europe, Japan, India, Australia, and China. The IRCM co-owns these patent families with Cornell University, located in New York state.

Stealth Peptides International Inc. (Stealth), a privately held biopharmaceutical company developing innovative therapies, has exclusively licensed commercial rights to the compounds and their various applications. Stealth plans to develop new treatments for metabolic, ophthalmologic, neurologic and cardio-renal diseases using these and other compounds.

Stealth's lead clinical candidate is BendaviaTM, a novel compound from this class of peptides that targets cell mitochondria to treat several acute and chronic diseases.

The first clinical program for Bendavia is for the treatment of ischemia reperfusion injury, a common complication of interventional procedures for acute myocardial infarction, a leading cause of death worldwide, as reported by the World Health Organization. An Investigational New Drug application for Bendavia was filed with the U.S. Food and Drug Administration and U.S. Phase I clinical trials began in May 2010. The initial U.S. Phase I clinical trial was designed to evaluate the clinical safety, tolerability and pharmacokinetics of Bendavia in healthy volunteers. In September 2010, Stealth's U.S. affiliate announced the completion of the U.S. Phase I study. The preliminary results from this clinical trial demonstrated that Bendavia appeared to be well tolerated at the doses evaluated, with no serious adverse events reported. A Phase II clinical trial has already begun in several countries.

In the "Top Ten"

Windhover, a company owned by Elsevier that plays a major role in the production of health industry analyses, chose Bendavia as one of the "Top 10" projects to watch for in 2011 in the development of therapies for cardiovascular and metabolic diseases.


'/>"/>
Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Related biology news :

1. Chemical equator discovery will aid pollution mapping
2. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
3. Groundbreaking discovery may lead to stronger antibiotics
4. Discovery of natural compounds that could slow blood vessel growth
5. Nanoscopic screening process to speed drug discovery
6. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
7. New $11 million center to speed production of new compounds for drug discovery
8. Discovery of giant roaming deep sea protist provides new perspective on animal evolution
9. New discovery may enhance MRI scans, lead to portable MRI machines
10. Kidney function discovery sheds light on genetic complexity of disease
11. Discovery of new gene associated with diabetes risk suggests link with body clock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/10/2016)... , March 10, 2016   Unisys Corporation ... and Border Protection (CBP) is testing its biometric identity ... San Diego to help identify certain non-U.S. citizens ... . The test, designed to help determine the efficiency and ... began in February and will run until May 2016. ...
(Date:3/9/2016)... , March 9, 2016  Crossmatch ® ... and enrollment solutions, today announced the addition of ... Altus multi-factor authentication platform. New contextual ... managers to step-up security where it,s needed most ... Washington, DC . --> ...
(Date:3/3/2016)... March 3, 2016  2016FLEX, organized by FlexTech, ... highlighting advancements in flexible, hybrid and printed electronics. ... attendance - have gathered for short courses, technical ... of electronics. The Flex Conference celebrates its 15 ... companies, R&D organizations, and universities contributing to the ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... April 27, 2016 , ... Cambridge Semantics, the leading ... today announced that it has been named to The Silicon Review’s “20 Fastest Growing ... other markets, Cambridge Semantics serves the needs of end users facing some of the ...
(Date:4/27/2016)... VANCOUVER, British Columbia , April 27, 2016 ... "Gesellschaft" oder "NanoStruck") (CSE: NSK) (OTCPink: NSKQB) ( ... sie im Anschluss an ihre Pressemitteilung vom 13. ... Inc. erhalten hat, ihre Finanzen um zusätzliche 200.000.000 ... auf 4.000.000 Kanadische Dollar zu bringen. Davon wurden ...
(Date:4/27/2016)... , ... April 27, 2016 , ... ... PhD to its Scientific Advisory Board. Dr. Lamka will assist PathSensors in expanding ... detection. , PathSensors deploys the CANARY® test platform for the detection of ...
(Date:4/27/2016)... 27, 2016 MedDay, a biotechnology company ... the appointment of Catherine Moukheibir as Chairman of its Board ... Jean Jacques Garaud , who contributed to the rapid ... immediately. Catherine started her career in strategy consulting ... London .  She held C-Suite level roles ...
Breaking Biology Technology: