Navigation Links
Discovery of the cell's water gate may lead to new cancer drugs
Date:6/17/2009

The flow of water into and out from the cell may play a crucial role in several types of cancer. Scientists at the University of Gothenburg, Sweden, have now found the gate that regulates the flow of water into yeast cells. The discovery, which will be published in the journal PLoS Biology, raises hopes of developing a drug that inhibits the spread and growth of tumours.

All living organisms must be able to regulate the flow of water into and out from cells, in order to maintain cell form and size. This regulation is carried out by special proteins known as "aquaporins". These act as water channels and control the flow of water into and out from the cell.

Involved in cancer diseases

Aquaporins are found in most organisms, and are believed to be involved in several diseases, including cancer. Research on mice has shown that inhibiting the function of aquaporins can dramatically reduce the spread and growth of tumours.

Important for research

It is therefore extremely important for cancer research to increase our knowledge of aquaporins. Scientists at the University of Gothenburg have recently achieved a minor breakthrough in the field. Karin Lindkvist at the Department of Cell and Molecular Biology and Richard Neutze at the Department of Chemistry, University of Gothenburg have determined the three-dimensional structure of the yeast aquaporin. The results will be published in the journal PLoS Biology.

Highest resolution

The structure has been determined using X-ray crystallography and is the highest resolution structure that has been determined for a membrane protein. The unique high resolution has enabled the scientists to answer one of the unsolved mysteries of biology. The aquaporins in yeast have long "tails", known as amino-terminal extensions. The function of these tails has, until now, been unknown.

"Our study shows that the amino-terminal extensions in
'/>"/>

Contact: Krister Svahn
krister.svahn@science.gu.se
46-031-786-4912
University of Gothenburg
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Discovery may help defang viruses
2. Stomach stem cell discovery could bring cancer insights
3. Symposium marks 30th anniversary of discovery of third domain of life
4. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
5. Natural product discovery by Cleveland medical researchers blocks tissue destruction
6. Researchers discovery may lead to hypertension treatment
7. Yale discovery suggests protein may play a role in severe asthma
8. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
9. Profound immune system discovery opens door to halting destruction of lupus
10. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
11. New discovery could reduce the health risk of high-fat foods
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of the cell's water gate may lead to new cancer drugs
(Date:6/16/2015)... June 16, 2015 Fingerprint Cards has ... sensors in the company,s portfolio from one of its module ... to mainly take place during the third quarter 2015. The ... Asia . Jörgen Lantto, CEO of FPC, ... the   growing interest from smartphone OEMs in integrating touch ...
(Date:6/15/2015)... June 16, 2015 According to ... by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, ... 2020" published by MarketsandMarkets, The Natural Language Processing Market ... CAGR of 18.4% for the forecast period 2015-2020. ... 46 F igures spread   through 155 P ...
(Date:6/15/2015)... --NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") ... market, announces that its leading payment security technology, the Wocket® ... @ NYC June 18th. Digital Experience! @ NYC ... technology to over 300 of the top media covering the ... in New York City from 6:00 ...
Breaking Biology News(10 mins):FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2Natural Language Processing Market Worth $13.4 Billion by 2020 2Natural Language Processing Market Worth $13.4 Billion by 2020 3Natural Language Processing Market Worth $13.4 Billion by 2020 4Natural Language Processing Market Worth $13.4 Billion by 2020 5Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 2Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 3
... that predict rapid onset of liver damage in hepatitis ... appeared soon after transplant and well before clinical evidence ... susceptibility to hepatitis C virus-induced liver injury could lead ... transplant. Also, because the markers stem from an ...
... believe is the key to understanding why the human ... other animals. The human brain, with its unequaled ... to know why," says James Sikela, PhD, who headed ... University of Colorado School of Medicine, Baylor College of ...
... sediments in Egypt,s Nile Delta document the region,s ancient ... ago associated with the demise of Egypt,s Old Kingdom, ... have a long history of having to deal with ... U.S. Geological Survey. "Along with other research, this study ...
Cached Biology News:Molecular and protein markers discovered for liver transplant failure from hepatitis C 2Molecular and protein markers discovered for liver transplant failure from hepatitis C 3Molecular and protein markers discovered for liver transplant failure from hepatitis C 4Evolutionary increase in size of the human brain explained 2Climate and drought lessons from ancient Egypt 2
(Date:7/1/2015)... 1, 2015  Axovant Sciences Ltd. (NYSE:  AXON), ... treatment of dementia, today announced that the company ... at 5:45 p.m. EDT following its presentation of ... Conference 2015 (AAIC). The event ... Dr. Lawrence Friedhoff , Chief Development Officer, ...
(Date:7/1/2015)... ... 2015 , ... NEMA 4 (IP66) Medical Joysticks can be ... have an impermeable molecular barrier protection against bio-hazardous agents. Original Equipment Manufacturers ... healthcare worker safety and reduce financial costs. , CTI Electronics announces a new ...
(Date:6/30/2015)... (PRWEB) , ... June 30, 2015 , ... ... is hosting a webinar to provide advanced scientific research into new classes of ... science and energy. Touted as 'the wonder material of the 21st Century' ...
(Date:6/30/2015)... ... June 30, 2015 , ... With its latest polyacrylonitrile (PAN) ... achieve faster flow rates in comparison to nylon or polyethersulfone (PES). Its ... allow easy liquid flow while trapping particulates as small as 0.2 micron in ...
Breaking Biology Technology:Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 3Sanitized Medical Joysticks for a Safer and Healthier Work Environment 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 3How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 4New Nanofiber Membrane Provides Fast, Efficient Filtration 2
... CLARKSVILLE, Md.., Sept. 15 Ne u r ona ... ., a privately-held biotechnology company developing novel, neurogenic small-molecule drugs for the treatment ... and Chief Scientific Officer, will present at the Life Sciences Summit 2009 -- S ... Inno v ation, Pr o ...
... , , ATLANTA, ... Bulletin Board: EAUI), a leading provider of electrolyzed water for ... a trial with a leading international beverage bottling company enabling ... a sanitation process for CIP (Clean-in-Place) applications. EAU,s electrolyzed ...
... , , , , ... makers of the patented probiotic strain GanedenBC30(R) , today ... The new thin strip product is the latest in a number of ... , , The recent popularity of thin strips as ...
Cached Biology Technology:Neuronascent to Present at Life Sciences Summit 2009 2EAU Completes Approval Process for Electrolyzed Water as Sanitation Process for Industrial Clean-in-Place Application 2EAU Completes Approval Process for Electrolyzed Water as Sanitation Process for Industrial Clean-in-Place Application 3EAU Completes Approval Process for Electrolyzed Water as Sanitation Process for Industrial Clean-in-Place Application 4Ganeden Biotech Introduces the First Probiotic Thin Strip 2Ganeden Biotech Introduces the First Probiotic Thin Strip 3
... The Sub-Cell Model 192 and PowerPac basic power ... of nucleic acids in agarose gels. This Model ... x 15 cm UV-transparent gel tray with fluorescent ... power supply, 100-120 and 220-240 V, provides output ...
The imaging screen-K (Kodak), tritium, is a 20 x 25 cm storage phosphor screen that is used for the quantitation and imaging of 32P, 33P, 35S, 14C, and 3H....
The filter 695RDF55 Reflect 635 for the Molecular Imager FX is a band pass filter for Cy5 and Alexa Fluor 635 dyes....
The filter 605DF50 for the Molecular Imager FX is a band pass filter for ethidium bromide, SYPRO Red, SYPRO Ruby, Alexa Fluor 532 and 546, and Cy3 dyes when using the 635 nm laser....
Biology Products: