Navigation Links
Discovery of the cell's water gate may lead to new cancer drugs
Date:6/17/2009

The flow of water into and out from the cell may play a crucial role in several types of cancer. Scientists at the University of Gothenburg, Sweden, have now found the gate that regulates the flow of water into yeast cells. The discovery, which will be published in the journal PLoS Biology, raises hopes of developing a drug that inhibits the spread and growth of tumours.

All living organisms must be able to regulate the flow of water into and out from cells, in order to maintain cell form and size. This regulation is carried out by special proteins known as "aquaporins". These act as water channels and control the flow of water into and out from the cell.

Involved in cancer diseases

Aquaporins are found in most organisms, and are believed to be involved in several diseases, including cancer. Research on mice has shown that inhibiting the function of aquaporins can dramatically reduce the spread and growth of tumours.

Important for research

It is therefore extremely important for cancer research to increase our knowledge of aquaporins. Scientists at the University of Gothenburg have recently achieved a minor breakthrough in the field. Karin Lindkvist at the Department of Cell and Molecular Biology and Richard Neutze at the Department of Chemistry, University of Gothenburg have determined the three-dimensional structure of the yeast aquaporin. The results will be published in the journal PLoS Biology.

Highest resolution

The structure has been determined using X-ray crystallography and is the highest resolution structure that has been determined for a membrane protein. The unique high resolution has enabled the scientists to answer one of the unsolved mysteries of biology. The aquaporins in yeast have long "tails", known as amino-terminal extensions. The function of these tails has, until now, been unknown.

"Our study shows that the amino-terminal extensions in
'/>"/>

Contact: Krister Svahn
krister.svahn@science.gu.se
46-031-786-4912
University of Gothenburg
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Discovery may help defang viruses
2. Stomach stem cell discovery could bring cancer insights
3. Symposium marks 30th anniversary of discovery of third domain of life
4. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
5. Natural product discovery by Cleveland medical researchers blocks tissue destruction
6. Researchers discovery may lead to hypertension treatment
7. Yale discovery suggests protein may play a role in severe asthma
8. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
9. Profound immune system discovery opens door to halting destruction of lupus
10. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
11. New discovery could reduce the health risk of high-fat foods
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of the cell's water gate may lead to new cancer drugs
(Date:7/22/2014)... that mutations in prickle genes cause epilepsy, which ... repeated seizures over time. However, the mechanism responsible ... new University of Iowa study, published online July ... Academy of Sciences , reveals a novel pathway ... identified the basic cellular mechanism that goes awry ...
(Date:7/22/2014)... fires started on July 14, 2014, by lightning from a ... Complex consists of four fires: Stokes Fire, Gold Hikes Fire, ... Gold Hikes fires are now one larger fire. The fires ... is currently over 243,000 acres in size. The present ... fire danger. Public and firefighter safety is the priority on ...
(Date:7/22/2014)... ,1000 Bull Genomes Project, aims to accelerate breeding for ... improving animal health and welfare. Results of the project,s ... of 234 individual bulls whose direct descendants number in ... journal Nature Genetics . , According to the ... or eliminate hereditary diseases and to improve the efficency ...
Breaking Biology News(10 mins):UI study finds potential genetic link between epilepsy and neurodegenerative disorders 2Whole-genome sequencing of bulls in key beef and dairy breeds 2
... Evolution is not a steady march towards ever more ... links" is pointless, according to findings published by a team ... de Montral,s Department of Biochemistry. "Aristotle was the first to ... Darwin,s theory of evolution continued this idea, with the concept ...
... Research presented today at the 31st Annual meeting of the ... found that three proteins known as XIAP, BID, and Bcl-2 ... in the prevention of preterm labor. They may also ... The proteins prevent preterm birth by hindering apoptosis ...
... 2011 -- Research presented today at the 31st Annual meeting ... Meeting has found that three proteins known as XIAP, BID, ... progesterone treatments in the prevention of preterm labor. They ... The proteins prevent preterm birth by hindering ...
Cached Biology News:New evolutionary research disproves living missing link theories 2New research helps explain how progesterone prevents preterm birth 2New research helps explain how progesterone preventspreterm birth 2
(Date:7/22/2014)... Two new members were elected to ... its annual Shareholders Meeting on June 13: Kerry R. ... PFM Group, and Stephen T. Zarrilli, President and CEO ... election of Michael A. DiPiano, Managing General Partner of ... P. Jaffe, Esq., of Duane Morris LLP, as Director ...
(Date:7/22/2014)... CAMBRIDGE, Massachusetts og SHENZHEN ... BGI Tech Solutions Co., LTD, (BGI Tech), et ... globale lancering af en ny human whole exome-sekvenseringstjeneste ... Complete Genomics, højt anset i branchen for ... og højfølsom registrering af alle typer varianter, blev ...
(Date:7/22/2014)... SHENZHEN, China , July 22, ... (BGI Tech), a subsidiary of BGI, the world,s ... of a new human whole exome sequencing service ... offered service includes in-depth bioinformatics analysis and SNP ... December 31, 2014. Complete Genomics, ...
(Date:7/22/2014)... July 22, 2014  Semler Scientific, Inc. (Nasdaq: ... risk assessment company that develops patented products that ... chronic diseases, today announced that it will report ... of U.S. financial markets on July 25, 2014. Doug Murphy-Chutorian, ... a conference call at 11 a.m. EDT, July 25, 2014. ...
Breaking Biology Technology:Two New Members Elected to University City Science Center Board of Directors 2Two New Members Elected to University City Science Center Board of Directors 3BGI Tech lancerer Human Whole Exome-sekvenseringstjeneste på Complete Genomics avancerede platform 2BGI Tech Launches Human Whole Exome Sequencing Service on Complete Genomics' Advanced Platform 2BGI Tech Launches Human Whole Exome Sequencing Service on Complete Genomics' Advanced Platform 3Semler to Report Second Quarter 2014 Financial Results and Host Conference Call on July 25, 2014 2
... Inc., a biotechnology corporation working on innovations for humane ... Siegel as Vice President of Business Development. , ... experience in executive management positions. He has served ... Information Technology Group, Inc., Director of ILINC Communications, Inc., ...
... from an alga so that it resembles the extremely efficient ... determine the structure of these light antennae. This is the ... leaf. The researchers will be publishing an article on their ... PNAS journal in the week starting 29 June. Leiden ...
... PROMOTIONAL SYSTEMS, INC. (Pink Sheets: VGPR) today announced it has ... to assist the Company in building a biomass production facility ... its intention to build a biomass plant in Georgia to ... State,s Bioenergy Corridor. Georgia ranks third in the nation ...
Cached Biology Technology:SenesTech Announces New Vice President of Business Development 2First step to converting solar energy using 'artificial leaf' 2Vega Picks Tennessee Firm to Assist with Construction of Biomass Plant in Georgia 2
... AccuPrime™ Pfx DNA Polymerase is ... fragments for downstream applications such as ... is provided by a proprietary enzyme ... Pyrococcus sp. with proofreading (3'Cut Site5' ...
... precision beveling of micropipette tips ... unique abrasive plate drive system ... control of the beveling process. ... rapidly and produces consistent tip ...
... 2 mM sodium phosphate buffer, pH 6.5. ... is a major lysosomal aspartyl protease in ... proenzyme. Overexpression of cathepsin D in human ... of relapse and metastasis. Cathepsin D degrades ...
Rat Hepatocytes (RH) (>3,000,000 cells)...
Biology Products: