Navigation Links
Discovery of taste receptors in the lungs could help people with asthma breathe easier
Date:10/24/2010

taste receptors in the lungs would prompt a 'fight or flight' response to a noxious inhalant, causing chest tightness and coughing so you would leave the toxic environment, but that's not what we found," says Dr. Liggett.

There are thousands of compounds that activate the body's bitter taste receptors but are not toxic in appropriate doses. Many are synthetic agents, developed for different purposes, and others come from natural origins, such as certain vegetables, flowers, berries and trees.

The researchers tested a few standard bitter substances known to activate these receptors. "It turns out that the bitter compounds worked the opposite way from what we thought," says Dr. Liggett. "They all opened the airway more profoundly than any known drug that we have for treatment of asthma or chronic obstructive pulmonary disease (COPD)." Dr. Liggett says this observation could have implications for new therapies. "New drugs to treat asthma, emphysema or chronic bronchitis are needed," he says. "This could replace or enhance what is now in use, and represents a completely new approach."

Quinine and chloroquine have been used to treat completely different diseases (such as malaria), but are also very bitter. Both of these compounds opened contracted airways profoundly in laboratory models. Even saccharin, which has a bitter aftertaste, was effective at stimulating these receptors. The researchers also found that administration of an aerosolized form of bitter substances relaxed the airways in a mouse model of asthma, showing that they could potentially be an effective treatment for this disease.

Dr. Liggett cautions that eating bitter tasting foods or compounds would not help in the treatment of asthma. "Based on our research, we think that the best drugs would be chemical modifications of bitter compounds, which would be aerosolized and then inhaled into the lungs with an inhaler," he says.

Another paradoxical aspect of the
'/>"/>

Contact: Sharon Boston
sboston@umm.edu
410-328-8919
University of Maryland Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Discovery may help scientists boost broccoli’s cancer-fighting power
2. Discovery of a mechanism that controls the expression of a protein involved in numerous cancers
3. OGI invests in drug discovery at InDanio Bioscience
4. T cell discovery shows promise for Type 1 diabetes treatment: UBC-CFRI study
5. Research breakthrough hailed on the anniversary of gene discovery
6. Discovery of a cell that suppresses the immune system
7. Census of Marine Life celebrates decade of discovery
8. Discovery of key pathway interaction may lead to therapies that aid brain growth and repair
9. Biofuel from inedible plant material easier to produce following enzyme discovery
10. Discovery offers hope of saving sub-Saharan crops from devastating parasites
11. Gene discovery holds key to growing crops in cold climates
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of taste receptors in the lungs could help people with asthma breathe easier
(Date:7/29/2014)... brings together two of the major disciplines behind Jurassic ... fossils through stunning photographs and unique illustrations. , Fossil ... details the incredible preservation and diversity of fossilised insects ... these remarkable fossils can tell us about the ancient ... planet. Like the mosquito in Jurassic Park, many of ...
(Date:7/29/2014)... study from UC San Francisco is the first to ... overtime and accelerate cellular aging, these negative effects may ... sleeping well. , "The study participants who exercised, ... than the ones who didn,t maintain healthy lifestyles, even ... author Eli Puterman, PhD, assistant professor in the department ...
(Date:7/28/2014)... Amundsen reached the South Pole in 1911, but new ... any human. , Using data from 16 ice cores ... including the South Pole, a group led by Joe ... Nevada, created the most accurate and precise reconstruction to ... new record, described in an article published today in ...
Breaking Biology News(10 mins):Unique images bring fossil insects back to life 2Healthy lifestyle may buffer against stress-related cell aging, study says 2Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3
... time when research funding is hard to come by, a ... landed almost $5.5 million in National Institutes of Health highly ... $3.6 million over five years is aimed at determining whether ... of hemophilia A more effective. The second grant worth $2 ...
... will be floating high above the Gulf of Mexico ... DNA analysis instrument developed at Tech that could benefit ... of mechanical engineering, and Collin Tranter, a graduate student ... instrument could be used to monitor the health of ...
... to react when their animals start behaving abnormally. The ... the symptoms are so variable. In some cases the ... which is generally considered to be how most cats spend ... is followed by twitching of facial muscles, chewing and swallowing ...
Cached Biology News:Hemophilia research gets NIH boost to a tune of $5.5 million 2Hemophilia research gets NIH boost to a tune of $5.5 million 3Louisiana Tech University researchers, NASA partner to conduct zero-gravity experiments 2Seizing the opportunity: treating epilepsy in cats 2
(Date:7/29/2014)... “PharmaSphere: Emerging Biotech Investment Report ... Funding” report provides in-depth analysis of the current ... venture capital segments of the financial industry, bearing ... significant impact on the future of emerging biotechnology ... report identifies regions of the world that are ...
(Date:7/29/2014)... Cat: Can a particle be separated from its properties? ... , published the results of the first Cheshire Cat ... by Chapman University in Orange, CA, and Vienna University ... cat without a grin," thought Alice in Wonderland, "but ... thing I ever saw in my life!" Alice,s surprise ...
(Date:7/29/2014)... 29, 2014 Second generation biofuels are a ... fossil fuels. However, as natural gas is very cheap, this ... are not as valuable as they could be in comparison ... financing projects, has made it difficult for renewable energy developers ... off the ground. For these reasons, certain companies have shifted ...
(Date:7/29/2014)... COLORADO SPRINGS, Colo. , July 29, 2014 ... Company specializing in cannabis formulation-based drug development and ... New York Times for taking a strong position ... in its Sunday, July 27, 2014 publication.  The ... upcoming editorials and articles this week exploring the ...
Breaking Biology Technology:Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 2Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 3Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 4The quantum Cheshire cat: Scientists separate a particle from its properties 2The quantum Cheshire cat: Scientists separate a particle from its properties 3The quantum Cheshire cat: Scientists separate a particle from its properties 4Renewable Waste Intelligence: Could Renewable Chemicals Be the Future for the Renewable Energy Industry? 2Cannabis Science, Inc. (CBIS) Applauds New York Times Editorial Board Stance on 'Repealing Prohibition, Again'; NYT Editorial Is Bell Weather of Change 2Cannabis Science, Inc. (CBIS) Applauds New York Times Editorial Board Stance on 'Repealing Prohibition, Again'; NYT Editorial Is Bell Weather of Change 3
... research team co-led by scientists from the J. Craig Venter ... of Maryland School of Medicine, today published the sequence and ... in Nature Biotechnology . Agnes P. Chan, Ph.D., JCVI, ... paper describing the 4.5X coverage of this important oilseed crop. ...
... In Vitro Toxicology Services -- MACCLESFIELD, England, August 20, 2010 ... ... var shortURL ... longUrl, so we need to grab the first one. for (var r in data.results) { first_result = ...
... SLN), a leading international RNAi therapeutics company, is pleased ... has announced the grant of an option to Novartis ... commercialise QPI-1002, a p53 temporary inhibitor siRNA drug which ... conducting a Phase II clinical trial of QPI-1002 for ...
Cached Biology Technology:Castor Bean Genome Published by Research Team Including Scientists from the Venter Institute 2Castor Bean Genome Published by Research Team Including Scientists from the Venter Institute 3Cyprotex Adds In Vitro Toxicology Services 2Cyprotex Adds In Vitro Toxicology Services 3Cyprotex Adds In Vitro Toxicology Services 4Cyprotex Adds In Vitro Toxicology Services 5Cyprotex Adds In Vitro Toxicology Services 6Silence Therapeutics' Partner Quark Signs Exclusive Option Agreement With Novartis for Development and Commercialisation of QPI-1002 2
Request Info...
... Universal Amplicon Detection Assay (ADA) ... the qualitative detection and quantitation ... in vitro nucleic acid amplification. ... to be used in diagnostic ...
{3,8-diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodide}. ,250 ug/ml Propidium Iodide (PI) in PBS....
... ready-to-use reagents for the isolation of genomic ... for the isolation of genomic DNA from ... for the isolation of genomic DNA from ... can be used for restriction endonuclease digestion ...
Biology Products: