Navigation Links
Discovery of taste receptors in the lungs could help people with asthma breathe easier
Date:10/24/2010

Taste receptors in the lungs? Researchers at the University of Maryland School of Medicine in Baltimore have discovered that bitter taste receptors are not just located in the mouth but also in human lungs. What they learned about the role of the receptors could revolutionize the treatment of asthma and other obstructive lung diseases.

"The detection of functioning taste receptors on smooth muscle of the bronchus in the lungs was so unexpected that we were at first quite skeptical ourselves," says the study's senior author, Stephen B. Liggett, M.D., professor of medicine and physiology at the University of Maryland School of Medicine and director of its Cardiopulmonary Genomics Program.

Dr. Liggett, a pulmonologist, says his team found the taste receptors by accident, during an earlier, unrelated study of human lung muscle receptors that regulate airway contraction and relaxation. The airways are the pathways that move air in and out of the lungs, one of several critical steps in the process of delivering oxygen to cells throughout the body. In asthma, the smooth muscle airways contract or tighten, impeding the flow of air, causing wheezing and shortness of breath.

The taste receptors in the lungs are the same as those on the tongue. The tongue's receptors are clustered in taste buds, which send signals to the brain. The researchers say that in the lung, the taste receptors are not clustered in buds and do not send signals to the brain, yet they respond to substances that have a bitter taste.

For the current study, Dr. Liggett's team exposed bitter-tasting compounds to human and mouse airways, individual airway smooth muscle cells, and to mice with asthma. The findings are published online in Nature Medicine.

Most plant-based poisons are bitter, so the researchers thought the purpose of the lung's taste receptors was similar to those in the tongue to warn against poisons. "I initially thought the bitter-
'/>"/>

Contact: Sharon Boston
sboston@umm.edu
410-328-8919
University of Maryland Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Discovery may help scientists boost broccoli’s cancer-fighting power
2. Discovery of a mechanism that controls the expression of a protein involved in numerous cancers
3. OGI invests in drug discovery at InDanio Bioscience
4. T cell discovery shows promise for Type 1 diabetes treatment: UBC-CFRI study
5. Research breakthrough hailed on the anniversary of gene discovery
6. Discovery of a cell that suppresses the immune system
7. Census of Marine Life celebrates decade of discovery
8. Discovery of key pathway interaction may lead to therapies that aid brain growth and repair
9. Biofuel from inedible plant material easier to produce following enzyme discovery
10. Discovery offers hope of saving sub-Saharan crops from devastating parasites
11. Gene discovery holds key to growing crops in cold climates
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of taste receptors in the lungs could help people with asthma breathe easier
(Date:8/19/2014)... supermarkets to encourage healthier spending habits? A new study ... question by tracking the purchasing records in a supermarket ... the nutritional value of foods for sale. , The ... PhD, and Brian Wansink PhD, author of Slim by ... Hannaford Supermarkets in the Northeastern United States between January ...
(Date:8/19/2014)... at retail seafood counters in 10 different states ... consumers to unexpectedly high levels of mercury, a ... a fish of the same species, but from ... offense, according to new research by University of ... seafood is essential to allow consumers to choose ...
(Date:8/19/2014)... during warm phases and became extinct during cold phases, ... link between marine crocodilian diversity and the evolution of ... million years. , The research, led by Dr ... formerly from the University of Bristol, UK is published ... are ,cold-blooded, animals that mainly live in fresh waters ...
Breaking Biology News(10 mins):Seafood substitutions can expose consumers to unexpectedly high mercury 2Seafood substitutions can expose consumers to unexpectedly high mercury 3Evolution of marine crocodilians constrained by ocean temperatures 2
... new information about a key protein,s role in the ... work could one day lead to new treatments for ... The University of Texas at Dallas, School of Behavioral ... student Francisco Garcia on a series of papers that ...
... Research!America Annual Advocacy Awards reception and dinner ... research including Senator Barbara Mikulski, D-(MD), winner of the ... other honorees: Sanjay Gupta, MD, the Emmy-Award winning chief ... of the National Library of Medicine; Margaret Foti, ...
... technology, satellite mapping, and ground-based plot surveys, a team ... of carbon stocks in remote and fragile Madagascar. The ... carbon stocks in rugged geographic regions and that this ... support conservation and climate-change mitigation under the United Nations ...
Cached Biology News:Study looks at possible link to hyper-excitability factors in epilepsy, autism and more 2Super high-resolution carbon estimates for endangered Madagascar 2
(Date:8/20/2014)... Resources Group finds that the vascular access device market in ... India and China (BRIC) was ... size of the United States market that ... growth as a result of strong economic expansion, improving access to ... Decision Resources Group,s coverage of the BRIC vascular access device market: ...
(Date:8/20/2014)... 2014 Not long ago, it was ... be performed late in the development cycle – even ... regulatory trends suggest that, like many things GxP, expectations ... recent years, multiple drug sponsors have been required by ... questions during phase I/II. It’s not only clinical trial ...
(Date:8/20/2014)... WriteResult®, a leading provider of Electronic ... expanded its myPROpad™ ePRO tablet with the addition of ... the most widely used and well-respected Patient Reported Outcome ... EQ-5D is used during clinical trials and in other ... be used to demonstrate Health-Related Quality of Life outcomes ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 Shimadzu ... chromatography systems, Prominence-i and Nexera-i, adding to the ... Combining excellent functionality, an intuitive operating environment, and ... a more efficient workflow for conventional to ultra-high-speed ... innovative, intuitive and intelligent design so users can ...
Breaking Biology Technology:BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 3Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2EQ-5D™ Assessment Now Available for iPad 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3
... February 8 /PRNewswire-FirstCall/,-- Evotec AG (Frankfurt Stock Exchange: EVT) today announced ... & Investor Conference,in New York., Date: ... 11.45 am EST (05.45 pm ... City, The presentation slides will be available on the Evotec ...
... AND FULL YEAR 2007 FINANCIAL RESULTS, 2008 OUTLOOK AND, ... ON CONFERENCE CALL AND WEBCAST, HAYWARD, Calif., Feb. ... discuss its fourth quarter and full year,2007 financial results, ... matters related to the company,s business on Thursday, February,28, ...
... CHAPEL HILL, N.C., Feb. 7 Falling stock prices,devaluing ... market,are just a few of the symptoms of the ... all industries, it may have a deeper impact,on pharma ... with,increasing pricing and regulatory pressures and decreasing numbers of ...
Cached Biology Technology:Kosan Announces February 28, 2008 Conference Call and Webcast 2Pharmaceutical Budget and Staffing: Powerful New Metrics-Based Study 2
OmniSlide Heated Wash Module. 2 independent chambers with precise temperature control from ambient of 5C to 70C. Each chamber holds 1 slide rack (20 slides). Includes 2 x Wash Sleeves, 1 x Slide R...
... bioassays for interferons are cytopathic effect inhibition assays, ... Sample types include; tissue culture supernatents; serum from ... assays, one unit is defined as the quantity ... cytopathic effect of viral infection by 50%. ...
... interferons are cytopathic effect inhibition assays, also known ... include; tissue culture supernatents; serum from PK studies ... unit is defined as the quantity of interferon ... of viral infection by 50%. All ...
OmniSlide thermal Cycler for slide applications. 20 slide capacity. Humidity Chamber. Slide Rack can be transferred directly to Wash Module to avoid handling individual slides....
Biology Products: