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Discovery of stem cell illuminates human brain evolution, points to therapies
Date:5/25/2010

tand how the new stem cells compare to radial glial cells and how the two sets of neurons they produce integrate in the neocortex. "Neurons are probably being generated in both the SVZ and OSVZ at once," he says. "They likely end up in the same layer of the neocortex as they migrate into position and start forming circuits.

"This suggests to us that there may be a mosaic of cell types in the human neocortex, in which there are cells that originate in the traditional zone and cells produced in the newer zone that intermix in the cortex. The complexity of primate neocortex may be significantly increased by the interaction of the evolutionarily-speaking 'younger' neurons with those originating in the more primitive zone."

The massive number of cells within the OSVZ of humans "tells us we have to be careful when modeling human brain diseases in mice," says Kriegstein. "Especially in the neocortex -- the most highly developed part of the brain in primates and humans there are going to be important differences between rodents and humans."


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Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

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