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Discovery of sexual mating in Candida albicans could provide insights into infections
Date:1/30/2013

Like many fungi and one-celled organisms, Candida albicans, a normally harmless microbe that can turn deadly, has long been thought to reproduce without sexual mating. But a new study by Professor Judith Berman and colleagues at the University of Minnesota and Tel Aviv University shows that C. albicans is capable of sexual reproduction.

The finding, published online by Nature January 30, represents an important breakthrough in understanding how this pathogen has been shaped by evolution, which could suggest strategies for preventing and treating the often serious infections that it causes.

The most common fungus that infects humans, C. albicans is part of the large community of microorganisms that live for the most part harmlessly within the human gut. But unlike many of its neighbors, this one-celled yeast can also cause disease, ranging from thrush (an oral infection) and vaginal yeast infections to systemic blood infections that cause organ failure and death and usually occur in people with immune defects related to HIV/AIDS, organ transplantation or chemotherapy. C. albicans is responsible for 400,000 deaths annually.

Most single-celled organisms reproduce by dividing, but others reproduce asexually, parasexually or via sexual mating. Scientists have long believed that C. albicans reproduce without mating.

Organisms that produce asexually or parasexually are diploid, which means they have two sets of chromosomes and thus can reproduce without a mate. Organisms that reproduce sexually are haploid, which means they have one set of chromosomes and need a mate to provide a second set. C. albicans was believed to be diploid, but this study shows that the yeast is sometimes haploid, and that these haploids are capable of sexual reproduction.

Sexual reproduction fuels the evolution of higher organisms because it combines DNA from two parents to create one organism. Th
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Contact: Matt Hodson
mjhodson@umn.edu
612-625-0552
University of Minnesota
Source:Eurekalert

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