Navigation Links
Discovery of reprogramming signature may help further stem cell-based regenerative medicine research
Date:9/19/2012

LA JOLLA, CA---- Salk scientists have identified a unique molecular signature in induced pluripotent stem cells (iPSCs), "reprogrammed" cells that show great promise in regenerative medicine thanks to their ability to generate a range of body tissues.

In this week's Proceedings of the National Academy of Sciences, the Salk scientists and their collaborators at University of California, San Diego, report that there is a consistent, signature difference between embryonic and induced pluripotent stem cells. The findings could help overcome hurdles to using the induced stem cells in regenerative medicine.

"We believe that iPSCs hold a great potential for the treatment of human patients," says Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory and the senior author on the paper. "Yet we must thoroughly understand the molecular mechanisms governing their safety profile in order to be confident of their function in the human body. With the discovery of these small, yet apparent, epigenetic differences, we believe that we are now one step closer to that goal."

Embryonic stem cells (ESCs) are known for their "pluripotency," the ability to differentiate into nearly any cell in the body. Because of this ability, it has long been thought that ESCs would be ideal to customize for therapeutic uses. However, when ESCs mature into specific cell types, and are then transplanted into a patient, they may elicit immune responses, potentially causing the patient to reject the cells.

In 2006, scientists discovered how to revert mature cells, which had already differentiated into particular cell types, such as skin cells or hair cells, back into a pluripotent state. These "induced pluripotent stem cells" (iPSCs), which could be developed from the patient's own cells, would theoretically carry no risk of immune rejection.

However, scientists found that iPSCs had molecular differences from embryonic stem c
'/>"/>

Contact: Andy Hoang
ahoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. King Richard III search in new phase after discovery has potential to rewrite history
2. New discovery related to gum disease
3. Cant smell anything? This discovery may give you hope
4. Chemicals today, drugs tomorrow: U-Ms new Center for Drug Discovery
5. Molecular movies may accelerate anti-cancer drug discovery
6. Gene discovery could improve treatment for acute myeloid leukemia
7. New discovery of how carbon is stored in the Southern Ocean
8. Gene discovery set to help with mysterious paralysis of childhood
9. 3-D tumor models improve drug discovery success rate
10. OHSU discovery may lead to new treatment for ALS
11. Groundbreaking discovery of mechanism that controls obesity, atherosclerosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of reprogramming signature may help further stem cell-based regenerative medicine research
(Date:9/17/2014)... Researchers at the Catalan Institute of Oncology-Bellvitge Biomedical ... identified 5 genes differentially expressed in normal accompanying ... could be used to classify colorectal tumors, predict ... appropriate clinical decisions to prevent relapses. , ... most common in our population considering both sexes. ...
(Date:9/17/2014)... decades of decline, grasses have returned to some once-denuded ... marsh in those places seems healthy again, but a ... the marsh coastal protection remains diminished. , ... hasn,t come back," said ecologist Mark Bertness, professor of ... in the journal Biological Conservation . "The metric ...
(Date:9/17/2014)... including MRSA and MSSA could be curbed by ... the scaly surface of shark skin, according to ... Antimicrobial Resistance and Infection Control . , The ... spread of human disease bacteria through touching, sneezes ... arrangement of ridges formulated to resemble shark skin. ...
Breaking Biology News(10 mins):Five genes to predict colorectal cancer relapses 2Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3Sharks' skin has teeth in the fight against hospital superbugs 2
... of a shift in U.S. demographics and importance of ... how do those growing toward majority acquire representation in ... that mentor and move minorities forward to majorities in ... that is gaining traction, said Castillo-Chavez, one of a ...
... Bunions bothering you? How about lower back pain, or impacted ... millennia to walk on two legs, grow larger brains and ... experienced some negative consequences on our way to becoming the ... But keeping our evolutionary history in mind can help us ...
... simultaneously to that which is visible and can be subjectively ... hunger is known as ,hidden hunger, or chronic malnutrition. Every ... hidden hunger before they are five years old. Year ... of starvation, which is responsible for the deaths of millions ...
Cached Biology News:Mentoring models to move minorities to majorities in STEM 2Mentoring models to move minorities to majorities in STEM 3Is there a Neanderthal in the house? 2Malnutrition -- Living hungrily ever after 2
(Date:9/18/2014)... Leatherwood Plastics has selected Vycom’s ... stay competitive in the semiconductor, clean room and ... impact product quality and productivity, according to Dwight ... in 1980 in Lewisville, TX, Leatherwood Plastics ... left the business. Much of Leatherwood’s equipment building ...
(Date:9/18/2014)... 2014 /PRNewswire/ - Oncothyreon Inc. (NASDAQ: ONTY ... but separate underwritten offerings of 10,000,000 shares of its ... $2.00 per share, for expected gross proceeds of $20 ... Preferred Stock at a price to the public of ... million. Each share of Series A Convertible Preferred Stock ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 SeqLL ... Sequencing (tSMS™) technology, announced today the closing of ... investment, led by Genomic Diagnostic Technologies, will increase ... diagnostic applications. , Founded in March 2013 by ... Bioinformatics Analyst at Helicos BioSciences, SeqLL has continued ...
(Date:9/18/2014)... at USC have developed a new microscopy technology ... living animals at higher-than-ever resolution. , Dubbed "Complementation ... imaging resolutions that are an order of magnitude ... into the behavior of biomolecules at the nanometer ... 18 by Nature Communications , the researchers ...
Breaking Biology Technology:Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2Scientists pioneer microscopy technique that yields fresh data on muscular dystrophy 2
... (phospho Y1007) ( Abpromise for ... Antigen: Synthesized phosphopeptide derived from ... of tyrosine 1007 (K-E-Y P -Y-K). ... 3717 Swiss ...
... Perm Buffer III is ... fixation of PBMCs (or ... staining for intracellular kinases ... simultaneously. Applications: Intracellular ...
Cytofix/Cytoperm Kit 250 Tests...
The BD PhosFlow Fix Buffer I can be used for the simultaneous fixation and permeabilization of cells prior to intracellular staining. Applications: Intracellular Staining (Flow) Storage Temperature:...
Biology Products: