Navigation Links
Discovery of protein that alters nutrition of breast cancer cells
Date:4/5/2011

This release is available in Spanish.

Research published in the Cancer Cell journal in March was a significant step in knowing the causes of cancer better, especially breast cancer, revealing that the lack or loss of a protein in the cells known as SIRT3, induces the proliferation of this disease and thereby, this protein can be an may be a therapeutic target in the development of effective therapies for cancer. The research was led by Dra. Marcia Haigis of the Harvard Medical School, with the participation of Dr. Arkaitz Carracedo, from the Proteomics Laboratory at CIC bioGUNE.

One of the grand aims of the scientific community is to identify the characteristics that differentiate normal cells from cancerous ones in order to subsequently develop therapies that wipe out the aberrant cells without affecting the normal ones. One 100 years ago, a researcher named Otto Warburg observed that cancerous cells feed in a singular manner: instead of using nutrients to produce energy, it seems they waste part of the food through a less efficient metabolism. Warburg maintained the hypothesis that cancer cells have an "aberrant", i.e. different metabolism; which he attributed to a technical defect in these cells. They did not use food to generate energy (ATP) but to generate biomass and build more cells, divide, proliferate, etc.

"In recent years, we have come to understand this phenomenon better. Paradoxically, the cancer cells obtain sufficient energy from nutrients - equivalent to the electricity for supplying all the appliances in our house while what is limiting for them is material to build more cells or what we can imagine as the bricks to build more houses, explained Dr. Carracedo. To this end, they modify their metabolism in order to create more of these building blocks (cell membrane, ADN, proteins, and so on). This change in the metabolic behaviour of the tumour cell is known as the Warburg Effect, in honour of the researcher".

With this precedent, it is clear that if the way the metabolism of tumour cells is reprogrammed can be understood, more powerful and specific therapies can be designed. This was the target of this research. Dr. Haigis's team focused their research on new proteins that regulate the metabolism of the cells and known as Sirtuins, and detected that if a protein of this family of Sirtuins (known as SIRT3) were eliminated from the cells, these modified their mode of feeding on and processing of nutrients, showing a remarkable similarity with a cancerous cell.

"We discovered that a loss of SIRT3 triggered the Warburg Effect. SIRT3 acts as a 'guardian' in the cell, ensuring that the metabolic processes function correctly. Nevertheless, with loss of SIRT3, another very important protein for the cell, known as HIF1α and which has to be strictly controlled, goes out of control and alters the metabolism", stated Dr. Carracedo.

According to this hypothesis, a cancerous cell will benefit from the elimination of SIRT3 protein. "We confirmed this idea after observing that cells in mice without SIRT3 generated cancers that developed more", stated Br Carracedo. "These genes are fighting constantly. When we lose the SIRT3 gene, the HIF1α protein increases, it destabilises. This promotes tumour growth".

In order to undertake the most important confirmation the extrapolation of data to the human being, pathologist and bioinformatics experts were included in this project , who helped to demonstrate that, effectively, many cancers and, principally breast cancer, presented reduced levels of SIRT3, together with signs of altered metabolism; arriving at the conclusion that SIRT3 protein is a 'guardian' of the metabolism, and that the design of pharmaceutical drugs for promoting this activation could be of great interest in the treatment of cancer.


'/>"/>

Contact: Oihane Lakar
o.lakar@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Related biology news :

1. Missouri Botanical Garden makes rare discovery of plant genus
2. Discovery of a biochemical basis for broccolis cancer-fighting ability
3. Discovery of source of glycogen manufacturing errors sheds light on fatal disease
4. MU researchers believe discovery could lead to testing that displaces colonoscopies
5. Discovery of blood proteins that are red flags for ectopic pregnancy
6. Final flight of space shuttle Discovery to carry 2 payloads built by CU-Boulder
7. UCSB chemists make discovery that may lead to drug treatment possibilities for Alzheimers
8. Discovery of jumping gene cluster tangles tree of life
9. Discovery may lead to turning back the clock on ovarian cancer
10. Cell binding discovery brings hope to those with skin and heart problems
11. University of Minnesota discovery suggests a new way to prevent HIV from infecting human cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: