Navigation Links
Discovery of pathway leading to depression reveals new drug targets
Date:12/6/2012

/p>

Finally, in order to test the findings, the researchers used a compound called purmorphamine, which is known to stimulate the Hedgehog pathway. They found that by using this drug, they were able to reverse the damaging effects of stress hormones, and normalise the production of new brain cells.

Dr Christoph Anacker, lead author of the study from King's Institute of Psychiatry says: "By decreasing the number of new-born cells in the human brain, stress hormones damage many important brain functions and may contribute to the development of depression after a period of chronic stress. By inhibiting the Hedgehog signalling pathway, stress hormones reduce the development of immature 'stem' cells into mature 'brain' cells."

Dr. Anacker continues: "With as much as half of all depressed patients failing to improve with currently available treatments, developing new, more effective antidepressants still remains a great challenge, which makes it crucial to identify new potential mechanisms to target. The discovery of antidepressants has so far been mainly by serendipity. Developing a drug with a defined effect on the brain, such as increasing the number of new-born brain cells, and with a clear target, such as Hedgehog signalling, will allow us to develop much more specific antidepressants in the future."


'/>"/>

Contact: Seil Collins
seil.collins@kcl.ac.uk
44-207-848-5377
King's College London
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery of 100 million-year-old regions of DNA shows short cut to crop science advances
2. Discovery of molecular pathway of Alzheimers disease reveals new drug targets
3. The Journal of Biological Chemistry commemorates an important 1987 discovery
4. GW Research chosen as paper of the week for blood coagulation discovery
5. NIH-funded genetic sequencing tool speeds drug discovery, disease diagnostics
6. Discovery of reprogramming signature may help further stem cell-based regenerative medicine research
7. King Richard III search in new phase after discovery has potential to rewrite history
8. New discovery related to gum disease
9. Cant smell anything? This discovery may give you hope
10. Chemicals today, drugs tomorrow: U-Ms new Center for Drug Discovery
11. Molecular movies may accelerate anti-cancer drug discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... , April 2, 2015 ... Q1 2015 attributed to somewhat higher than 125 MSEK. ... the year-end report 2014 that revenues for Q1 2015 ... the company reported for Q4 2014. The operating result ... be negative. The complete interim report will as previously ...
(Date:3/31/2015)... March 31, 2015  Elephant Talk Communications Corp. (NYSE ... provider of Software Defined Network Architecture (ET Software DNA® ... revenue of approximately $20.4 million for the year ended ... million for the year ended December 31, 2013. ... Company had completed its multi-year transition away from its ...
(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ... of the "Global Iris Recognition Market 2015-2019" ... the Global Iris Recognition market to grow at a ... This report covers the present scenario and the ... the period 2015-2019. To calculate the market size, the ...
Breaking Biology News(10 mins):Fingerprint Cards Revises Revenues for Q1 2015 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2
... Following an agreement between ESA, Krunichev Space Centre and ... and a secondary payload, the technology demonstrator Proba-2 satellite, ... new November launch date follows a rescheduling of the ... Moisture and Ocean Salinity (SMOS) satellite and the secondary ...
... heat shock protein 90 gets steroid receptors into shape ... to targeted therapies for hormone-driven cancers, such as breast ... of Georgia researchers say. "We are trying to ... conformation so they work," says Dr. Ahmed Chadli, biochemist ...
... In the fruit fly,s developing brain, stem cells called ... cell that has a different fate. But neuroblast growth can ... Researchers at Duke-NUS Graduate Medical School in Singapore ... a counterpart in mammals, that can apparently prevent brain tumors ...
Cached Biology News:SMOS and Proba-2 launch rescheduled for November 2Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease 2Tumor suppressor gene in flies may provide insights for human brain tumors 2
(Date:4/20/2015)... 20, 2015 Global Stem Cells ... Meeting 2015, an annual gathering of aesthetic medicine experts ... is scheduled to introduce the company’s brand new training ... adipose-derived stem cell techniques. , The course is ... in the aesthetic field, including facial aging caused by ...
(Date:4/17/2015)... 2015 Reed Technology and Information ... data management, preparation, and submission to the U.S. Food ... a new Lot Distribution Report (LDR) service for manufacturers ... compliant with the FDA’s new rule on electronic submission ... monitor the volume and timing of particular biologics introduced ...
(Date:4/17/2015)... drug discovery company, Novogen, today announced that it ... Feinstein Institute for Medical Research (,Feinstein Institute,) of ... with the objective of developing effective treatments for ... the drug discovery expertise of Novogen and the ... in neurosciences and oncology. At the ...
(Date:4/16/2015)... 17, 2015 Spirax Sarco, the ... released their newly designed, state-of-the-art website in the ... website effectively promotes the Spirax Sarco brand, company ... information that a site visitor might be looking ... capabilities, industries serviced, the latest company news, careers, ...
Breaking Biology Technology:Global Stem Cells Group to Host Featured Speaker at The Aesthetic Meeting 2015 in Montreal 2Global Stem Cells Group to Host Featured Speaker at The Aesthetic Meeting 2015 in Montreal 3Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 2Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 4Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 5Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 6Spirax Sarco website has a new look 2
... Doug Valentine aka "DoctorLoopy" Wins Grand Prize with One-of-a-kind Video ... Viewers Watched and Voted for the Best Video Response to: "What Do ... The National Park Foundation and Olympus ... teacher from Melissa, TX, is the grand prize winner of the " ...
... ... and cGMP manufacturer, announced that the company is in the initial phases of a ... Pharmaceutical Ingredient (API) manufacturing facility located in Riverview, Michigan. Expansions will include a new ... ...
... ... with the first PDSS Leadership Award at the 3rd Annual Pacific Drug Safety Summit, which ... outcomes researcher, was the moderator of the event and serves as Chairman of BioSoteria,s Board ... Emeryville, CA ...
Cached Biology Technology:The National Park Foundation and Olympus Announce Winner of the First-Ever 'Your Parks' Video Challenge 2The National Park Foundation and Olympus Announce Winner of the First-Ever 'Your Parks' Video Challenge 3The National Park Foundation and Olympus Announce Winner of the First-Ever 'Your Parks' Video Challenge 4Ash Stevens Plans $6 Million Facility Expansion to Bolster CMC Capabilities 2Hugh Tilson Receives Leadership Award at Pacific Drug Safety Summit 2Hugh Tilson Receives Leadership Award at Pacific Drug Safety Summit 3
... shaking and rocking for maximal fluid movement. This ... stainless steel or acrylic platform, it is perfect ... The platform angle is easily adjusted from 0 ... and rotation speed of platform is adjusted from ...
...
Monoclonal Anti-Cystatin A tissue culture supernatant Solution containing 15 mM sodium azide human cystatin A ...
... are a line of pre-integrated and ... and reliable automated solutions to specific ... building blocks, Caliper has created compact, ... conventional approaches, take up little lab ...
Biology Products: