Navigation Links
Discovery of pathway leading to depression reveals new drug targets
Date:12/6/2012

Scientists have identified the key molecular pathway leading to depression, revealing potential new targets for drug discovery, according to research led by King's College London's Institute of Psychiatry. The study, published today in Neuropsychopharmacology, reveals for the first time that the 'Hedgehog pathway' regulates how stress hormones, usually elevated during depression, reduce the number of brain cells.

Depression affects approximately 1 in 5 people in the UK at some point in their lives. The severity of symptoms can range from feelings of sadness and hopelessness to, in the most severe cases, self-harm or suicide. Treatment for depression involves either medication or talking treatment, or usually a combination of the two.

Recent studies have demonstrated that depression is associated with a reduction in a brain process called 'neurogenesis'- the ability of the brain to produce new brain cells. However, the pathway responsible for this process has, until now, remained unknown.

In this study, Dr Christoph Anacker from King's Institute of Psychiatry and his team studied human stem cells, which are the source of new cells in the human brain, to investigate the effect of stress hormones on brain cell development. The study was funded by the National Institute for Health Research Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College London and the Medical Research Council UK.

Stress hormones, such as cortisol, are generally elevated in stress and depression. The team studied stem cells in a laboratory and found that high concentrations of cortisol damaged these stem cells and reduced the number of newborn brain cells. They discovered that a specific signalling mechanism in the cell, the 'Hedgehog pathway', is responsible for this process. Then, using an animal model, the team confirmed that exposure to stress inhibited this pathway in the brain.

Finally, in order to test the findings, the researchers used a compound called purmorphamine, which is known to stimulate the Hedgehog pathway. They found that by using this drug, they were able to reverse the damaging effects of stress hormones, and normalise the production of new brain cells.

Dr Christoph Anacker, lead author of the study from King's Institute of Psychiatry says: "By decreasing the number of new-born cells in the human brain, stress hormones damage many important brain functions and may contribute to the development of depression after a period of chronic stress. By inhibiting the Hedgehog signalling pathway, stress hormones reduce the development of immature 'stem' cells into mature 'brain' cells."

Dr. Anacker continues: "With as much as half of all depressed patients failing to improve with currently available treatments, developing new, more effective antidepressants still remains a great challenge, which makes it crucial to identify new potential mechanisms to target. The discovery of antidepressants has so far been mainly by serendipity. Developing a drug with a defined effect on the brain, such as increasing the number of new-born brain cells, and with a clear target, such as Hedgehog signalling, will allow us to develop much more specific antidepressants in the future."


'/>"/>

Contact: Seil Collins
seil.collins@kcl.ac.uk
44-207-848-5377
King's College London
Source:Eurekalert

Related biology news :

1. Discovery of 100 million-year-old regions of DNA shows short cut to crop science advances
2. Discovery of molecular pathway of Alzheimers disease reveals new drug targets
3. The Journal of Biological Chemistry commemorates an important 1987 discovery
4. GW Research chosen as paper of the week for blood coagulation discovery
5. NIH-funded genetic sequencing tool speeds drug discovery, disease diagnostics
6. Discovery of reprogramming signature may help further stem cell-based regenerative medicine research
7. King Richard III search in new phase after discovery has potential to rewrite history
8. New discovery related to gum disease
9. Cant smell anything? This discovery may give you hope
10. Chemicals today, drugs tomorrow: U-Ms new Center for Drug Discovery
11. Molecular movies may accelerate anti-cancer drug discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... 2017  Hunova, the first robotic gym for the rehabilitation and functional ... in Genoa, Italy . The first 30 robots will ... USA . The technology was developed and patented at ... IIT spin-off Movendo Technology thanks to a 10 million euro investment from ... click: ...
(Date:5/16/2017)... 16, 2017  Veratad Technologies, LLC ( www.veratad.com ), ... and identity verification solutions, announced today they will participate ... May 15 thru May 17, 2017, in ... Trade Center. Identity impacts the lives ... today,s quickly evolving digital world, defining identity is critical ...
(Date:5/16/2017)...   Bridge Patient Portal , an enterprise ... EMR Systems , an electronic medical record solutions ... established a partnership to build an interface between ... Centricity™ products, including Centricity Practice Solution (CPS), Centricity ... new integrations will allow healthcare delivery networks using ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... ... May 25, 2017 , ... Activate Healthcare, a leading ... of America’s fastest growing private companies, has selected Twine for its Employee Health ... through its transformative model that empowers deep collaboration and behavior change. In randomized ...
(Date:5/26/2017)... Yorba Linda, Ca (PRWEB) , ... May 25, ... ... a number of Terumo BCT case studies, describing how process development ... learn from new results of T-cell expansion using a hollow-fiber bioreactor system, along ...
(Date:5/26/2017)... ... May 25, 2017 , ... Studying biological events ... occurrence. Live cell imaging using fluorescence microscopy is the perfect approach to explore ... microscopy methods will be discussed, from small animal models and tissues to individual ...
(Date:5/26/2017)... ... May 25, 2017 , ... LabRoots , the ... and scientists from around the world, is announcing a new textbook scholarship, the second ... undergraduate and graduate students, 17 years or older, pursuing a degree in one of ...
Breaking Biology Technology: