Navigation Links
Discovery of new gene associated with diabetes risk suggests link with body clock
Date:12/7/2008

A connection between the body clock and abnormalities in metabolism and diabetes has been suggested in new research by an international team involving the University of Oxford, the Wellcome Trust Sanger Institute and the MRC Epidemiology Unit in Cambridge.

The researchers have identified a gene involved in the way the body responds to the 24 hour day-night cycle that is strongly linked to high blood sugar levels and an increased risk of type 2 diabetes. The results of the genome-wide association scan are published in Nature Genetics.

"We have extremely strong, incontrovertible evidence that the gene encoding melatonin receptor 1B is associated with high fasting glucose levels and increased risk of type 2 diabetes," says Professor Mark McCarthy of the Oxford Centre for Diabetes, Endocrinology and Metabolism at the University of Oxford.

Melatonin is a hormone that is strongly tied to control of our sleep-wake cycles, with concentrations in the blood peaking at night-time and dipping during the day. As a result, melatonin is implicated in conditions like jetlag and sleep disorders.

Disrupted sleep patterns are known to be associated with a range of health problems including metabolic disorders like diabetes, but it is not understood how they are connected. In identifying a link between a melatonin receptor and blood sugar levels, this study provides genetic evidence that mechanisms controlled by our body clock are connected to the machinery that keeps us metabolically healthy. It seems likely that the action of melatonin on the pancreas is being disturbed in this case, the researchers suggest.

The international research collaboration combined ten genome-wide association scans involving a total of over 36,000 individuals of European descent. A variant in the gene encoding melatonin receptor 1B (MTNR1B) showed a rise of 0.07 mmol/l in fasting glucose level on average and a 9% increase in risk of type 2 diabetes for
'/>"/>

Contact: Jonathan Wood
jonathan.wood@admin.ox.ac.uk
44-018-652-80530
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Kidney function discovery sheds light on genetic complexity of disease
2. New discovery may enhance MRI scans, lead to portable MRI machines
3. Discovery of giant roaming deep sea protist provides new perspective on animal evolution
4. New $11 million center to speed production of new compounds for drug discovery
5. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
6. Nanoscopic screening process to speed drug discovery
7. Discovery of natural compounds that could slow blood vessel growth
8. Groundbreaking discovery may lead to stronger antibiotics
9. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
10. Chemical equator discovery will aid pollution mapping
11. Life Sciences Discovery Fund advances latest research proposals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 1 (PS1) absorbs light and its energy is ... to biomass. Photovoltaic devices, mostly build from silicon ... electricity. One approach for the development of cheaper ... with the isolated membrane protein complexes of photosynthesis. ... stable PS1 from thermophilic cyanobacteria that live in ...
(Date:8/19/2014)... made to decrease China,s increasing caesarean section rate, suggests ... BJOG: An International Journal of Obstetrics and Gynaecology (BJOG) ... delivery rates in the world. Of 16 million babies ... the exact rate is not known, the current Chinese ... caesarean rates ranging from 36% to 58%. However, before ...
(Date:8/19/2014)... German . ... If a large amount of electricity is to be produced ... have to be stored during productive periods so that these ... far from adequate for the purpose. Science and industry are ... on battery systems that used to be too expensive or ...
Breaking Biology News(10 mins):A semi-artificial leaf faster than 'natural' photosynthesis 2Is China's 50 percent cesarean section delivery rate too high? 2Is China's 50 percent cesarean section delivery rate too high? 3Asian inventions dominate energy storage systems 2Asian inventions dominate energy storage systems 3
... be the focus of a talk by Upmanu Lall, director of ... at 3 p.m. in the NJIT Campus Center Ballroom. ... world, and the time for taking effective compensating action is growing ... which is part of the NJIT Technology and Society Forum presentation ...
... and conservationists from the Wildlife Conservation Society,s Guatemala Program, ... and other groups report a major conservation victory from ... fledglings that have now taken flight over the forests ... macaws, a big success for conservationists working in the ...
... Imagine a cellphone battery that stayed charged for more ... dream battery could be closer to reality thanks to Northwestern ... an electrode for lithium-ion batteries -- rechargeable batteries such as ... batteries to hold a charge up to 10 times greater ...
Cached Biology News:Wildlife Conservation Society helps scarlet macaws take flight in Guatemala 2Better batteries 2Better batteries 3
(Date:8/18/2014)... with unprecedented efficiency and data storage may ... built-in electric polarizations to read and write ... popular data-driven technology. But ferroelectrics must first ... a curious habit of "forgetting" stored data. ... Department of Energy,s Brookhaven National Laboratory have ...
(Date:8/18/2014)... August 18, 2014 According ... Market Research "Life Science Reagents Market(Products- PCR Reagent ... Chromatography, In-Vitro Diagnostic Reagents and Others; End Users- ... Clinical Laboratories, and Forensic Laboratories)- Global Industry Analysis, ... 2019", the global life science reagents market was ...
(Date:8/18/2014)... Fla. , Aug. 18, 2014 TNI ... biotechnology company pioneering the manufacturing and marketing of innovative ... that the Company is providing a second notice of ... In making the announcement, Noreen Griffin , ... you in advance for your participation in the Annual ...
(Date:8/18/2014)... (PRWEB) August 18, 2014 China ... opportunity for the clinical research industry. Clinicaltrial.gov statistics ... due to its aging population; a high increase ... diseases; a densely populated pool of patients and ... Notwithstanding these positive points, China also presents challenges ...
Breaking Biology Technology:Promising ferroelectric materials suffer from unexpected electric polarizations 2Promising ferroelectric materials suffer from unexpected electric polarizations 3Promising ferroelectric materials suffer from unexpected electric polarizations 4Global Life Science Reagents Market Expected to Reach USD 25.7 Billion in 2019: Transparency Market Research 2Global Life Science Reagents Market Expected to Reach USD 25.7 Billion in 2019: Transparency Market Research 3Global Life Science Reagents Market Expected to Reach USD 25.7 Billion in 2019: Transparency Market Research 4Global Life Science Reagents Market Expected to Reach USD 25.7 Billion in 2019: Transparency Market Research 5TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 2TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 3TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 4China – Land of Opportunities & Challenges for the Clinical Research Industry, New Webinar Hosted by Xtalks 2
... (Nasdaq: KOSN ) will announce its first quarter ... close., The announcement of Kosan,s first quarter 2008 ... live webcast on May 1, 2008 at 1:30,p.m. Pacific ... live,call by dialing 888.680.0878 (US) or 617.213.4855 (international), access,code ...
... the locations of biotech crops. , Access to maps ... give researchers greater ability to analyze the effects of biotech ... insects. , "Since 1996 more than a billion ... said Michelle Marvier of Santa Clara University in Calif. "We ...
... /PRNewswire/ ETEX Corporation, an advanced,biomaterials company, announced ... supply,agreement with AlloSource., (Logo: http://www.newscom.com/cgi-bin/prnh/20080424/NETH117LOGO ... with Demineralized Bone Matrix (DBM),powder to be ... phosphate to form EquivaBone(TM)., This agreement ...
Cached Biology Technology:Kosan Announces May 1, 2008 Conference Call and Webcast of First Quarter 2008 Financial Results 2Scientists call for more access to biotech crop data 2ETEX Announces Supply Agreement with AlloSource 2
... Light Diagnostics Cytomegalovirus (CMV) pp65 Antigenemia Immunofluorescence ... identification of lower matrix protein pp65 of ... Kit Components: Erythrocyte ... bottle containing 220 mL of buffered ammonium ...
... The CultureWell cell culture systems ... preparing cultured cells for staining ... medical-grade silicone gaskets preassembled with ... culture plates. The entire system ...
nuclear cap binding protein subunit 1, 80kDa, mRNA...
GOAT ANTI SLI...
Biology Products: