Navigation Links
Discovery of natural antibody brings a universal flu vaccine a step closer
Date:7/7/2011

uses in lab-dish tests and in mice. The affected viruses include H3 and H7, two subtypes of great concern for human health that have already caused a pandemic (H3) or sporadic human infections (H7).

As with the CR6261 project, Ekiert and colleagues were able to grow crystals of the new antibody bound to an HA protein from a deadly strain of H3N2, and to use X-ray crystallography techniques to determine the antibody's structure and its precise epitope on the viral HA protein.

"It's even lower on the HA stalk than the CR6261 epitope; in fact it's closer to the viral envelope than any other influenza antibody epitope we've ever seen," said Ekiert.

Crucell is about to begin initial clinical trials of CR6261 in human volunteers, and the company expects eventually to begin similar trials of CR8020. If those trials succeed, aside from a vaccine the two antibodies could be combined and used in a "passive immunotherapy" approach. "This would mainly be useful as a fast-acting therapy against epidemic or pandemic influenza viruses," said Wilson. "The ultimate goal is an active vaccine that elicits a robust, long-term antibody response against those vulnerable epitopes; but developing that is going to be a challenging task."


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Life Sciences Discovery Fund helps launch 3 programs to advance health research and development
2. Trudeau Institute announces new discovery in battle against plague and bacterial pneumonias
3. UC Riverside neuroscientists discovery could bring relief to epilepsy sufferers
4. New discovery -- copepods share divers weight belt technique with whales
5. Cancer protein discovery may aid radiation therapy
6. Quantum sensor tracked in human cells could aid drug discovery
7. Discovery of canine hepatitis C virus opens up new doors for research on deadly human pathogen
8. Social network helps in discovery of a species of plant lice for the first time in Europe
9. Discovery of DNA silencing mechanism reveals how plants protect their genome
10. Serendipity leads to lifesaving discovery
11. Discovery demonstrates potential MS therapy could kill brain cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... 27, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces that ... customers the first week of May, 2015 and will ... May. Gino Pereira , Chief ... the company as Wocket® enters the consumer market. We ...
(Date:4/21/2015)... High crime rate, increasing ... access control systems market in Saudi Arabia ... published report by TechSci Research " Saudi Arabia Access Control ... systems market in Saudi Arabia ... control systems market in the Kingdom is growing at ...
(Date:4/20/2015)... April 20, 2015 The announcement ... Glenbeigh Records Management (GRM), Ireland,s ... Islamic Bank. Having built up an impressive track record of ... leading player within the records management sector in ... double is GCC staffbase and employ a further eight staff ...
Breaking Biology News(10 mins):Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... A tissue-repair-and-regeneration pathway in the human body, including wound ... properly. Genetically engineered mice fail to develop lungs ... are knocked out. The findings are described this week ... know the answer to a seemingly simple question: What ...
... and city officials recently signed a memorandum of understanding ... temperate rainforest education and research center in Juneau. The ... will stimulate and develop temperate rainforest education and research. ... of the University of Alaska Southeast, University of Alaska ...
... NOAA Fisheries scallop survey off the northeastern U.S. coast ... "recruit" sea scallops and ocean quahogs on Georges Bank ... Mid-Atlantic for 2009. This survey, which included the first ... underwater imaging system from the same vessel, also shows ...
Cached Biology News:How to make a lung 2New collaborative center to provide education, research on temperate rainforests 2Annual survey shows high numbers of seed scallops on Georges Bank, low numbers in Mid-Atlantic 2Annual survey shows high numbers of seed scallops on Georges Bank, low numbers in Mid-Atlantic 3Annual survey shows high numbers of seed scallops on Georges Bank, low numbers in Mid-Atlantic 4
(Date:5/28/2015)... , May 28, 2015 RXi Pharmaceuticals Corporation ... discovering and developing innovative therapeutics, primarily in the areas ... a public offering of 26 million units at a ... gross proceeds of approximately $10.4 million. Each unit consists ... 13-month overallotment purchase right to purchase 0.50 of a ...
(Date:5/28/2015)... New York and London (PRWEB) May 28, 2015 ... CFD-focused provider of Computer Aided Engineering software, announced ... Solid Research, Inc. (PSRI). CD-adapco will provide state-of-the-art ... PSRI members will share their expertise and experiences ... chemical and refining industry members and advance the ...
(Date:5/28/2015)... 2015 Whitehouse Laboratories is excited to ... term partnership with PTI Inspection Systems. Whitehouse Labs and ... with custom-tailored method development and validation programs using ... The agreement includes a more formal program that facilitates ... lines. This enables a more effective team approach, especially ...
(Date:5/28/2015)... Virginia (PRWEB) May 28, 2015 ... LLC announced today that Roger L. Williams, MD, ... consultant. NDA Partners Premier Experts are top tier ... to bring extraordinary value to the company’s clients. ... solutions to help clients successfully develop their medical ...
Breaking Biology Technology:RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 3CD-adapco and PSRI Chartering New Course in Particle Flow Simulations 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 3Former CEO and Chair of the Council of Experts at the USP, Roger L. Williams, MD, Joins NDA Partners as a Premier Expert Consultant 2
... store all the films ever made on a device the ... few metallic atoms could make it possible to build radically ... components for spintronics devices. There,s just one obstacle on the ... temperatures a few hairs above absolute zero. Now a chemistry ...
... Ga., March 28, 2011 MiMedx Group, Inc.  (OTC ... manufacturer and marketer of patent protected biomaterial-based products and ... results for the year ended December 31, 2010. ... changed its fiscal year to coincide with the calendar ...
... DRIVE4COPD, the nation,s single largest awareness campaign for ... Healthcare Campaign of the Year 2011.  The ... honors in the public relations industry, given each year ...  Boehringer Ingelheim Pharmaceuticals, Inc. is the founding sponsor of ...
Cached Biology Technology:Heavy metals open path to high temperature nanomagnets 2MiMedx Group Announces 2010 Results 2MiMedx Group Announces 2010 Results 3MiMedx Group Announces 2010 Results 4MiMedx Group Announces 2010 Results 5MiMedx Group Announces 2010 Results 6MiMedx Group Announces 2010 Results 7DRIVE4COPD Wins PRWeek Healthcare Campaign of the Year 2011 2DRIVE4COPD Wins PRWeek Healthcare Campaign of the Year 2011 3DRIVE4COPD Wins PRWeek Healthcare Campaign of the Year 2011 4
... Luminescent Detection System is intended for use ... generated by an in-house validated method for ... selected target of interest. • ... is a hybridization capture assay designed to ...
... for cell culture scale-up, these culture chambers ... - 10 9 range and are ... spinner flasks. • High mechanical • strength ... prior to shipping • Certified nonpyrogenic and ...
Mouse monoclonal [7B9] to beta II Tubulin ( Abpromise for all tested applications). Antigen: Synthetic peptide, CEEEEGEDEA found at the c-terminus of beta II tubulin. Entrez GeneID: 10383 ...
...
Biology Products: