Navigation Links
Discovery of natural antibody brings a universal flu vaccine a step closer
Date:7/7/2011

LA JOLLA, CA July 7, 2011 Annually changing flu vaccines with their hit-and-miss effectiveness may soon give way to a single, near-universal flu vaccine, according to a new report from scientists at The Scripps Research Institute and the Dutch biopharmaceutical company Crucell. They describe an antibody that, in animal tests, can prevent or cure infections with a broad variety of influenza viruses, including seasonal and potentially pandemic strains.

The finding, published in the journal Science Express on July 7, 2011, shows the influenza subtypes neutralized with the new antibody include H3N2, strains of which killed an estimated one million people in Asia in the late 1960s.

"Together this antibody and the one we reported in 2009 have the potential to protect people against most influenza viruses," said Ian Wilson, who is the Hansen Professor of Structural Biology and a member of the Skaggs Institute for Chemical Biology at Scripps Research, as well as senior author of the new paper with Crucell's chief scientific officer Jaap Goudsmit.

Tackling a Major Shortcoming

Wilson's laboratory has been working with Crucell scientists since 2008 to help them overcome the major shortcoming of current influenza vaccines: They work only against the narrow set of flu strains that the vaccine makers predict will dominate in a given year, so their effectiveness is temporary. In addition, current influenza vaccines provide little or no protection against unforeseen strains.

These shortcomings reflect a basic flu-virus defense mechanism. The viruses come packaged in spherical or filamentous envelopes that are studded with mushroom-shaped hemagglutinin (HA) proteins, whose more accessible outer structures effectively serve as decoys for a normal antibody response. "The outer loops on the HA head seem to draw most of the antibodies, but in a given strain these loops can mutate to evade an antibody response within mon
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Life Sciences Discovery Fund helps launch 3 programs to advance health research and development
2. Trudeau Institute announces new discovery in battle against plague and bacterial pneumonias
3. UC Riverside neuroscientists discovery could bring relief to epilepsy sufferers
4. New discovery -- copepods share divers weight belt technique with whales
5. Cancer protein discovery may aid radiation therapy
6. Quantum sensor tracked in human cells could aid drug discovery
7. Discovery of canine hepatitis C virus opens up new doors for research on deadly human pathogen
8. Social network helps in discovery of a species of plant lice for the first time in Europe
9. Discovery of DNA silencing mechanism reveals how plants protect their genome
10. Serendipity leads to lifesaving discovery
11. Discovery demonstrates potential MS therapy could kill brain cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... or simply cli-fi, is a newly coined term for novels ... New research from University of Copenhagen shows how these fictions ... the potential consequences of climate change and imagine other living ... data on changes in the atmosphere; it is also a ... books we read and the films we see. And there ...
(Date:4/23/2014)... HOUSTON, April 23, 2014 A biomedical engineer at ... highly innovative technology to make blood transfusions safer. His ... the National Institutes of Health (NIH). , Blood ... one of modern medicine,s absolute necessities. Without them, for ... mean transfusions are perfect, however. There,s strong evidence that ...
(Date:4/22/2014)... to get your child to behave at the dinner tablecut ... study published in Eating Behaviors , found that when ... with their front teeth such as drumsticks, whole apples, or ... these foods had been cut. "They were twice as ... kids," said Brian Wansink, Professor and Director of the Cornell ...
Breaking Biology News(10 mins):Fiction prepares us for a world changed by global warming 2Fiction prepares us for a world changed by global warming 3UH biomedical engineer works to make blood transfusions safer 2UH biomedical engineer works to make blood transfusions safer 3Biting vs. chewing 2
... our genomes can be traced back to strange rogue sequences known ... mammals. But Johns Hopkins researchers report they have identified a new ... its class found to be active in mammals. The discovery, described ... Proceedings of the National Academy of Sciences , offers a ...
... new research report published in the Journal ... known for causing gum disease-- Porphyromonas gingivalis --manipulates the ... otherwise destroy it. Specifically, the report shows that this ... (IL-10). This, in turn, inhibits the function of T-cells, ...
... carried out at Imperial College London and the University of ... would help prevent miscarriage in women who are particularly vulnerable. ... embed itself in the lining of the uterus. The uterus ... each menstrual cycle, ensuring that embryos can only implant at ...
Cached Biology News:Rare form of active 'jumping genes' found in mammals 2Smile: Gingivitis bacteria manipulate your immune system so they can thrive in your gums 2Scientists pinpoint molecular signals that make some women prone to miscarriage 2
(Date:1/15/2014)... January 15, 2014 The Microcompetition with Foreign ... disease. One of these latent viruses is the Epstein Barr ... (RA). Rheumatoid arthritis (RA) is a chronic inflammatory disease that ... study found that RA patients have high concentrations of EBV ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 AudioNotch is ... new therapy for the treatment of tinnitus. Patients listen ... frequency, and over a period of weeks to months, their ... Therapy in two forms: Notched Music and Notched White Noise. ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Histogen, Inc., ... products of cells grown under simulated embryonic conditions, today ... agreement with Suneva Medical, Inc. for physician-dispensed aesthetic products ... , This agreement is an amendment to the ...
(Date:1/14/2014)... The largest international professional organization of scientists ... derivatives thereof has endorsed an educational program that ... challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural Product ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8
... remotes are catching on in large University of Wisconsin-Madison ... mean students are kicking back and watching Comedy Central ... buttons, let them respond instantly to multiple-choice questions posed ... some students who might feel embarrassed to raise their ...
... is an integral place of business, the online reality is ... Web sites. , ,Many Internet surfers often believe they ... intuition is based on a number of surface-level factors. For ... it appears in the natural results of a search engine ...
... says it has bought a new copy machine for $57,000. ... "enlarge" feature than the typical office copier: It makes three-dimensional ... and the Anthrax virus. , ,Using white polymer powder and ... tall one layer at a time. Z-Corp is headquartered in ...
Cached Biology Technology:Many still distrust Web sites is yours credible enough? 2Many still distrust Web sites is yours credible enough? 3
... (Ribonuclease inhibitor) is a 50 ... inhibit RNase activity. It does ... activity. , Inhibits RNase ... template , Lacks DNA ...
... of GC-rich nucleic acids ,The GC-RICH ... Polymerase and a proofreading polymerase, powers through ... amplify with other polymerases and other blends ... blend and the unique GC-RICH Resolution Solution ...
... For nucleofection of optimized cell lines in ... the nucleofection parameters. Nucleofector Kits are only ... Different cell lines can be transfected with ... are given in brackets in percent (Efficiency ...
... PCR Workstation brings together UV irradiation and ... environment against PCR contamination! Quickly inactivate ... Maintain a clean environment with antimicrobial coated ... reagents within minutes with built-in 30-minute timer ...
Biology Products: