Navigation Links
Discovery of key pathway interaction may lead to therapies that aid brain growth and repair
Date:9/16/2010

WASHINGTON, DCResearchers at the Center for Neuroscience Research at Children's National Medical Center have discovered that the two major types of signaling pathways activated during brain cell developmentthe epidermal growth factor receptor pathway and the Notch pathwayoperate together to determine how many and which types of brain cells are created during growth and repair in developing and adult brains. This knowledge may help scientists design new ways to induce the brain to repair itself when these signals are interrupted, and indicate a need for further research to determine whether disruptions of these pathways in early brain development could lead to common neurodevelopmental disorders such as epilepsy, cerebral palsy, autism, Down syndrome, ADHD, and intellectual disabilities.

"By understanding how these cellular signaling pathways operate in the brain, we may be able to develop genetic or molecular approaches that target those signals to facilitate or induce regeneration of the brain from neural stem cells," said Vittorio Gallo, PhD, director of the Center for Neuroscience Research at Children's National. "These signaling pathways, normally activated during brain development, work in concert through the cellular microenvironment and through interactions with existing brain cells to determine how many of each type of brain cell are required for proper brain function."

These findings will be published in the September issue of Nature.

Dr. Gallo and the research team used an approach in a laboratory setting that modified genes involved in the two signaling pathways. This approach induced gain or loss of function, allowing researchers to change the properties of neural stem cells as they developedincluding altering the size of the pool of
'/>"/>

Contact: Jennifer Stinebiser
jstinebi@cnmc.org
202-476-4500
Children's National Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biofuel from inedible plant material easier to produce following enzyme discovery
2. Discovery offers hope of saving sub-Saharan crops from devastating parasites
3. Gene discovery holds key to growing crops in cold climates
4. First discovery of bilirubin in a flower announced
5. Report: Discovery networks hostage-taking a rare terror event
6. New discovery suggests our lungs are innately prone to silicosis and related diseases
7. A plan to promote sustainable US scientific discovery and innovation in the 21st century is proposed in OMICS
8. Discovery opens door to therapeutic development for FSH muscular dystrophy
9. Possible discovery of earliest animal life pushes back fossil record
10. Discovery of possible earliest animal life pushes back fossil record
11. Huntingtons disease discovery provides new hope for treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... Canadian wildfires have been raging this summer and some of ... U.S. In this image collected by the Moderate Resolution ... 2014 a swath of smoke has descended over the Great ... interesting is the fire image from July 23, 2014 (first ... smoke as it drifts off southeastward. In the image, ...
(Date:7/25/2014)... Birla, associate professor of biomedical engineering at the ... on tissue engineering and artificial organ development., "Introduction ... comprehensive guide to entering into the field of ... professor of biomedical engineering at UH, served as ... that while there are other published books on ...
(Date:7/25/2014)... Spina bifda (SB) is a complex congenital central ... incomplete closing of the neural tubes during the ... spasticity, urinary and fecal incontinence and neurocognitive retardation. ... their quality of life. Researchers at Ankara Physical ... investigate the functional performance in children with SB, ...
Breaking Biology News(10 mins):University of Houston researcher publishes textbook on tissue engineering 2
... scientific studies of the effects on wildlife of large-scale ... assess their impact, especially in the desert Southwest, according ... Geological Survey and published in the journal BioScience ... the paper, USGS scientist Jeffrey Lovich and Maryville College ...
... oil spill in the Gulf of Mexico, the U.S. ... Engineering and National Research Council to convene a committee ... disaster and identify measures for preventing similar harm in ... IMPROVING OFFSHORE DRILLING SAFETY, the committee,s final report, analyzes ...
... believe decision making mechanisms in the human brain could mirror ... similarities have been found in decision making systems between humans ... bees could teach us about how our brains work. ... an often paralysing thought process in humans, with scouts who ...
Cached Biology News:Literature review on solar energy and wildlife impacts research 2Swarms of bees could unlock secrets to human brains 2
(Date:7/24/2014)... 24, 2014 -- A novel combination of microscopy and ... Energy,s Oak Ridge National Laboratory an unprecedented look at ... physical and electrochemical properties. , The research team ... the surface of a perovskite manganite, a complex material ... avenue to understand surface behavior could benefit researchers who ...
(Date:7/24/2014)... 24, 2014  Now available is a stem cell ... Regenerative Therapies , located in Guadalajara, Mexico ... people a new health option: stem cell therapies ... countless patients suffer from joint and muscle injuries due ... tears, torn rotator cuff, tennis elbow, and knee injuries. ...
(Date:7/24/2014)... Calif. , July 24, 2014  ECC West ... Denver, Colorado with University College Hospital (UCH) ... a development project to finance, design, construct, and operate ... Nigeria . Under the first of ... prepare scoping documents and funding applications. UCH Ibadan intends ...
(Date:7/24/2014)... A research team led by group leader Yung-Eun ... technology to synthesize sulfur-doped and nitrogen-doped graphenes which ... secondary batteries and fuel cells. Yung-Eun Sung is ... Nanoparticle Research at Institute for Basic Science* (IBS) ... , This achievement has great significance with regards ...
Breaking Biology Technology:ORNL study reveals new characteristics of complex oxide surfaces 2Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2
... present the 2011 "ALBERT EINSTEIN" World Award of Science ... Distinguished University Professor University of Toronto, Canada. ... Ozin as the winner of the 2011 "ALBERT EINSTEIN" ... the field of nanochemistry that have helped to define ...
... Pharmaceuticals, Inc. (Nasdaq: ANDS ) is updating the ... Nicolaus Healthcare Conference to Thursday, September 8, 2011 at 4:25 ... at the Four Seasons Hotel in Boston.  Steve Worland, Ph.D., ... overview of Anadys and its clinical development programs, setrobuvir and ...
... ALCLS), the French genome engineering specialist, will present at the UBS ... 2011, and at the MidCap Event in Paris on September 22 ... the activities and the development strategy of the Cellectis group at ... York hotel on Tuesday, September 20, 2011 at 11:30 am ET. ...
Cached Biology Technology:2011 Awards of World Cultural Council 22011 Awards of World Cultural Council 32011 Awards of World Cultural Council 42011 Awards of World Cultural Council 5Anadys Pharmaceuticals Updates Its Presentation Date at the Stifel Nicolaus Healthcare Conference 2
Can be used for the quantitative recovery of small amounts of nucleic acids within dilute solutions. 5mg/ml...
APOPTAG® Plastic Coverslips are designed to be custom fitted to the specific APOPTAG® kit application. Each coverslip has 2.5 x 1 dimensions....
Human VEGF-D Biotinylated MAb (Clone 78923)...
Recombinant Mouse TGF-beta RII/(human) Fc Chimera, CF...
Biology Products: