Navigation Links
Discovery of key pathway interaction may lead to therapies that aid brain growth and repair
Date:9/16/2010

WASHINGTON, DCResearchers at the Center for Neuroscience Research at Children's National Medical Center have discovered that the two major types of signaling pathways activated during brain cell developmentthe epidermal growth factor receptor pathway and the Notch pathwayoperate together to determine how many and which types of brain cells are created during growth and repair in developing and adult brains. This knowledge may help scientists design new ways to induce the brain to repair itself when these signals are interrupted, and indicate a need for further research to determine whether disruptions of these pathways in early brain development could lead to common neurodevelopmental disorders such as epilepsy, cerebral palsy, autism, Down syndrome, ADHD, and intellectual disabilities.

"By understanding how these cellular signaling pathways operate in the brain, we may be able to develop genetic or molecular approaches that target those signals to facilitate or induce regeneration of the brain from neural stem cells," said Vittorio Gallo, PhD, director of the Center for Neuroscience Research at Children's National. "These signaling pathways, normally activated during brain development, work in concert through the cellular microenvironment and through interactions with existing brain cells to determine how many of each type of brain cell are required for proper brain function."

These findings will be published in the September issue of Nature.

Dr. Gallo and the research team used an approach in a laboratory setting that modified genes involved in the two signaling pathways. This approach induced gain or loss of function, allowing researchers to change the properties of neural stem cells as they developedincluding altering the size of the pool of neural stem cells in the brain, the number of viable neural stem cells, and types of brain cells these stem cells ultimately become.

Neural stem cells can develop into all major cell types of the brain. The discovery of the interaction between the two types of cellular signaling pathways is a critical step toward understanding, and potentially impacting, the molecular networks that regulate the cellular microenvironments, or niches, in which these neural stem cells operate.

"Children's National provides an ideal setting for pursuing this research, because we are able to use a multidisciplinary approach to our studies," Dr. Gallo said. "Investigators and clinical fellows work together in the labs to tackle important questions that have great clinical importance for children with neurodevelopmental disabilities, and tap resources and expertise at other institutions as well. This environment allows us to translate our findings into the design of specific therapeutic approaches, working together with neuroscientists, child neurologists, neurosurgeons, and neuro-oncologists."


'/>"/>

Contact: Jennifer Stinebiser
jstinebi@cnmc.org
202-476-4500
Children's National Medical Center
Source:Eurekalert

Related biology news :

1. Biofuel from inedible plant material easier to produce following enzyme discovery
2. Discovery offers hope of saving sub-Saharan crops from devastating parasites
3. Gene discovery holds key to growing crops in cold climates
4. First discovery of bilirubin in a flower announced
5. Report: Discovery networks hostage-taking a rare terror event
6. New discovery suggests our lungs are innately prone to silicosis and related diseases
7. A plan to promote sustainable US scientific discovery and innovation in the 21st century is proposed in OMICS
8. Discovery opens door to therapeutic development for FSH muscular dystrophy
9. Possible discovery of earliest animal life pushes back fossil record
10. Discovery of possible earliest animal life pushes back fossil record
11. Huntingtons disease discovery provides new hope for treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... N.Y. , June 23, 2017  IBM (NYSE: ... dairy research, today announced a new collaboration using next-generation ... chances that the global milk supply is impacted by ... Cornell University has become the newest academic institution to ... a food safety initiative that includes IBM Research, Mars, ...
(Date:6/14/2017)... , June 15, 2017  IBM (NYSE: IBM ) ... international tech event dedicated to developing collaboration between startups and ... on June 15-17. During the event, nine startups will showcase ... value in various industries. France ... the international market, with a 30 percent increase in the ...
(Date:5/23/2017)... robotic gym for the rehabilitation and functional motor sense evaluation of lower ... . The first 30 robots will be available from June in ... The technology was developed and patented at the IIT laboratories and has ... to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
Breaking Biology News(10 mins):
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... Biova, LLC., ... Ph.D. has joined Biova’s Board of Directors. Dr. Henig will bring a wealth of ... Henig has served as the Chief Technical and Scientific Officer of four major global ...
(Date:6/23/2017)... Frederick, MD (PRWEB) , ... June 23, 2017 ... ... laboratory software solutions provider, announced the latest version of LimitLIS®, its rapidly growing ... designed to speed up user adoption, ensure installation integrity, and provide more customization ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ken Hanson, a medical imaging ... Instrumente USA, have been selected as this year’s recipients of two top awards from ... been invited along with other honorees to accept their awards at a banquet in ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... website for all six of their healthcare job boards. As the largest ... and occupational therapists, and biotechnicians, DocCafe.com and the MedJobCafe.com Health Network work ...
Breaking Biology Technology: