Navigation Links
Discovery of key pathway interaction may lead to therapies that aid brain growth and repair
Date:9/16/2010

WASHINGTON, DCResearchers at the Center for Neuroscience Research at Children's National Medical Center have discovered that the two major types of signaling pathways activated during brain cell developmentthe epidermal growth factor receptor pathway and the Notch pathwayoperate together to determine how many and which types of brain cells are created during growth and repair in developing and adult brains. This knowledge may help scientists design new ways to induce the brain to repair itself when these signals are interrupted, and indicate a need for further research to determine whether disruptions of these pathways in early brain development could lead to common neurodevelopmental disorders such as epilepsy, cerebral palsy, autism, Down syndrome, ADHD, and intellectual disabilities.

"By understanding how these cellular signaling pathways operate in the brain, we may be able to develop genetic or molecular approaches that target those signals to facilitate or induce regeneration of the brain from neural stem cells," said Vittorio Gallo, PhD, director of the Center for Neuroscience Research at Children's National. "These signaling pathways, normally activated during brain development, work in concert through the cellular microenvironment and through interactions with existing brain cells to determine how many of each type of brain cell are required for proper brain function."

These findings will be published in the September issue of Nature.

Dr. Gallo and the research team used an approach in a laboratory setting that modified genes involved in the two signaling pathways. This approach induced gain or loss of function, allowing researchers to change the properties of neural stem cells as they developedincluding altering the size of the pool of
'/>"/>

Contact: Jennifer Stinebiser
jstinebi@cnmc.org
202-476-4500
Children's National Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biofuel from inedible plant material easier to produce following enzyme discovery
2. Discovery offers hope of saving sub-Saharan crops from devastating parasites
3. Gene discovery holds key to growing crops in cold climates
4. First discovery of bilirubin in a flower announced
5. Report: Discovery networks hostage-taking a rare terror event
6. New discovery suggests our lungs are innately prone to silicosis and related diseases
7. A plan to promote sustainable US scientific discovery and innovation in the 21st century is proposed in OMICS
8. Discovery opens door to therapeutic development for FSH muscular dystrophy
9. Possible discovery of earliest animal life pushes back fossil record
10. Discovery of possible earliest animal life pushes back fossil record
11. Huntingtons disease discovery provides new hope for treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... 24, 2015 Research and Markets ( ... "Global Iris Recognition Market 2015-2019" report to their ... Recognition market to grow at a CAGR of 23.5 ... covers the present scenario and the growth prospects of ... To calculate the market size, the report considers the ...
(Date:3/24/2015)... NexID Biometrics LLC, whose spoof-mitigation technology boosts protection ... beginning of shipments of version 2.0 of its industry ... in Potsdam, N.Y. , is making ... here today at the Walter E. Washington Convention Center. ... boosts the accuracy rate range to 96.5 to 99.5 ...
(Date:3/23/2015)... 23, 2015 SoundView Technology Group issues a new ... NXTD ) Wocket smart wallet. SoundView was one of the selected ... experience with the Wocket in multiple scenarios and outlets. ... and other retailers, making both debit and credit card payments.  ... says, "If the company meets their plans in 2015, it ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4
... The bubbles in your champagne that appear to jump out ... quite similar to the tiny bubbles found throughout the world,s oceans, ... the champagne bubbles are likely to raise your spirits, those in ... "Bubbles are little packets of gases that rise or fall ...
... in the American diet by as little as one-half teaspoon ... attacks and 92,000 deaths each year, according to a new ... from reductions in smoking and could save the United States ... A team from the University of California, San Francisco, ...
... PHILADELPHIA - Biologists at the University of Pennsylvania studying ... longstanding conundrum: How can organisms be robust against the ... changes? The short answer, according to University ... two requirements are often not contradictory and that an ...
Cached Biology News:Bubble physicist counts bubbles in the ocean to answer questions about climate, sound, light 2Bubble physicist counts bubbles in the ocean to answer questions about climate, sound, light 3Even small dietary reductions in salt could mean fewer heart attacks, strokes and deaths 2Even small dietary reductions in salt could mean fewer heart attacks, strokes and deaths 3Penn biologists explain how organisms can tolerate mutations, yet adapt to environmental change 2
(Date:4/21/2015)... PROVO, Utah , April 21, 2015  Tute Genomics, ... the hiring of Josh Forsythe as VP of ... that has witnessed a significant expansion in its commercial operations ... " Josh Forsythe is a ... Robison , MD MBA, CEO of Tute Genomics. "Josh,s vast ...
(Date:4/21/2015)... RESEARCH TRIANGLE PARK, N.C. , April 21, 2015 ... announced today that it will release its first quarter ... 28, 2015. United Therapeutics will host a ... a.m. Eastern Time.  The teleconference is accessible by dialing ... the teleconference will be available for one week and ...
(Date:4/21/2015)... Whether it’s used for troubleshooting in a ... a Kessler CineDrive in a cinematic studio setting, ... TS3-H is designed to help any shooter create vivid ... sensor, the TS5-H offers the same convenient touchscreen controls and ... , According to Tom Boldt for Fastec, “We believe that ...
(Date:4/20/2015)... (PRWEB) April 20, 2015 PMG ... its 12th clinical research site: PMG Research of Christie ... operation of the clinical research department at Christie ... the Southeast to a second region within the United ... physician practice enhances PMG’s access to an additional 80,000 ...
Breaking Biology Technology:Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 2Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 3Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 4Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 2Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 3PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 2PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 3
... N.Y., March 24 China,s State Food ... the pioneering Lucid VivaScope(R),reflective confocal microscope in ... CEO of Lucid, a Rochester, New York-based ... improved care for dermatology,patients., Lucid,s VivaScope(R) ...
... CMPMedica has expanded,SearchMedica.com to include a number ... conditions. SearchMedica.com was co-,developed with Convera Corporation ... , a,leading provider of vertical search services ... ), SearchMedica.com has been serving primary ...
... 24 An information technology,revolution is improving ... (PROs), according to Supportive Oncology Services, Inc. ... TN. PROs are self-,assessments that measure any ... from the patient without any interpretation by ...
Cached Biology Technology:Lucid's VivaScope(R) Reflective Confocal Microscope Approved for Sale in China 2Lucid's VivaScope(R) Reflective Confocal Microscope Approved for Sale in China 3CMPMedica Expands SearchMedica.com with Multiple Additional Vertical Search Applications co-developed with Convera(R) 2CMPMedica Expands SearchMedica.com with Multiple Additional Vertical Search Applications co-developed with Convera(R) 3Patient-Reported Outcomes (PROs) Improve Cancer Treatment -- Experts Agree 2Patient-Reported Outcomes (PROs) Improve Cancer Treatment -- Experts Agree 3
...
...
...
... Radiolabeled Ligands\n\nReceptor-related research has long been enabled ... ligands selected to keep pace with new ... products and services for receptor research and ... If you do not find exactly what ...
Biology Products: