Navigation Links
Discovery of key pathway interaction may lead to therapies that aid brain growth and repair
Date:9/16/2010

WASHINGTON, DCResearchers at the Center for Neuroscience Research at Children's National Medical Center have discovered that the two major types of signaling pathways activated during brain cell developmentthe epidermal growth factor receptor pathway and the Notch pathwayoperate together to determine how many and which types of brain cells are created during growth and repair in developing and adult brains. This knowledge may help scientists design new ways to induce the brain to repair itself when these signals are interrupted, and indicate a need for further research to determine whether disruptions of these pathways in early brain development could lead to common neurodevelopmental disorders such as epilepsy, cerebral palsy, autism, Down syndrome, ADHD, and intellectual disabilities.

"By understanding how these cellular signaling pathways operate in the brain, we may be able to develop genetic or molecular approaches that target those signals to facilitate or induce regeneration of the brain from neural stem cells," said Vittorio Gallo, PhD, director of the Center for Neuroscience Research at Children's National. "These signaling pathways, normally activated during brain development, work in concert through the cellular microenvironment and through interactions with existing brain cells to determine how many of each type of brain cell are required for proper brain function."

These findings will be published in the September issue of Nature.

Dr. Gallo and the research team used an approach in a laboratory setting that modified genes involved in the two signaling pathways. This approach induced gain or loss of function, allowing researchers to change the properties of neural stem cells as they developedincluding altering the size of the pool of neural stem cells in the brain, the number of viable neural stem cells, and types of brain cells these stem cells ultimately become.

Neural stem cells can develop into all major cell types of the brain. The discovery of the interaction between the two types of cellular signaling pathways is a critical step toward understanding, and potentially impacting, the molecular networks that regulate the cellular microenvironments, or niches, in which these neural stem cells operate.

"Children's National provides an ideal setting for pursuing this research, because we are able to use a multidisciplinary approach to our studies," Dr. Gallo said. "Investigators and clinical fellows work together in the labs to tackle important questions that have great clinical importance for children with neurodevelopmental disabilities, and tap resources and expertise at other institutions as well. This environment allows us to translate our findings into the design of specific therapeutic approaches, working together with neuroscientists, child neurologists, neurosurgeons, and neuro-oncologists."


'/>"/>

Contact: Jennifer Stinebiser
jstinebi@cnmc.org
202-476-4500
Children's National Medical Center
Source:Eurekalert

Related biology news :

1. Biofuel from inedible plant material easier to produce following enzyme discovery
2. Discovery offers hope of saving sub-Saharan crops from devastating parasites
3. Gene discovery holds key to growing crops in cold climates
4. First discovery of bilirubin in a flower announced
5. Report: Discovery networks hostage-taking a rare terror event
6. New discovery suggests our lungs are innately prone to silicosis and related diseases
7. A plan to promote sustainable US scientific discovery and innovation in the 21st century is proposed in OMICS
8. Discovery opens door to therapeutic development for FSH muscular dystrophy
9. Possible discovery of earliest animal life pushes back fossil record
10. Discovery of possible earliest animal life pushes back fossil record
11. Huntingtons disease discovery provides new hope for treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/29/2016)... , Nov. 29, 2016   Neurotechnology ... and object recognition technologies, today released FingerCell ... fingerprint recognition solutions that run on low-power, ... template using less than 128KB of memory, ... devices that have limited on-board resources, such ...
(Date:11/22/2016)... According to the new market research report "Biometric ... Signature, Voice), Multi-Factor), Component (Hardware and Software), Function (Contact and Non-contact), Application, ... is expected to grow from USD 10.74 Billion in 2015 to reach ... and 2022. Continue Reading ... ...
(Date:11/17/2016)... 17, 2016 Global Market Watch: Primarily ... Banks, Population-Based Banks and Academics) market is to witness a ... Biobanks shows the highest Compounded Annual Growth Rate (CAGR) of ... during the analysis period 2014-2020. North America ... followed by Europe at 9.56% respectively. ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... -- Research and Markets has announced the addition ... Companies" to their offering. ... , , This report ... technologies such as proteomics and metabolomics. Molecular diagnostics technologies are used ... on biomarker. Currently the most important applications of biomarkers ...
(Date:12/5/2016)... , Dec. 5, 2016 /PRNewswire/ - Resverlogix ...  that the independent Data and Safety Monitoring Board ... in high-risk cardiovascular disease (CVD) patients has completed ... the study should continue as planned without any ... noted that no safety or efficacy concerns were ...
(Date:12/4/2016)... ... December 02, 2016 , ... A proposed ... businesses in federally funded research and development is welcome news for the photonics ... photonics . , As part of the National Defense Authorization Act (NDAA) compromise ...
(Date:12/2/2016)... Dec. 2, 2016 More than $4.3 million was ... Medals dinner ( DHMD ). The gala was held at the ... York City and honored Alan Alda ... to health and medicine and the public understanding of science. ... 2006, the event has raised $40 million for the Laboratory,s ...
Breaking Biology Technology: