Navigation Links
Discovery of key pathway interaction may lead to therapies that aid brain growth and repair
Date:9/16/2010

WASHINGTON, DCResearchers at the Center for Neuroscience Research at Children's National Medical Center have discovered that the two major types of signaling pathways activated during brain cell developmentthe epidermal growth factor receptor pathway and the Notch pathwayoperate together to determine how many and which types of brain cells are created during growth and repair in developing and adult brains. This knowledge may help scientists design new ways to induce the brain to repair itself when these signals are interrupted, and indicate a need for further research to determine whether disruptions of these pathways in early brain development could lead to common neurodevelopmental disorders such as epilepsy, cerebral palsy, autism, Down syndrome, ADHD, and intellectual disabilities.

"By understanding how these cellular signaling pathways operate in the brain, we may be able to develop genetic or molecular approaches that target those signals to facilitate or induce regeneration of the brain from neural stem cells," said Vittorio Gallo, PhD, director of the Center for Neuroscience Research at Children's National. "These signaling pathways, normally activated during brain development, work in concert through the cellular microenvironment and through interactions with existing brain cells to determine how many of each type of brain cell are required for proper brain function."

These findings will be published in the September issue of Nature.

Dr. Gallo and the research team used an approach in a laboratory setting that modified genes involved in the two signaling pathways. This approach induced gain or loss of function, allowing researchers to change the properties of neural stem cells as they developedincluding altering the size of the pool of
'/>"/>

Contact: Jennifer Stinebiser
jstinebi@cnmc.org
202-476-4500
Children's National Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biofuel from inedible plant material easier to produce following enzyme discovery
2. Discovery offers hope of saving sub-Saharan crops from devastating parasites
3. Gene discovery holds key to growing crops in cold climates
4. First discovery of bilirubin in a flower announced
5. Report: Discovery networks hostage-taking a rare terror event
6. New discovery suggests our lungs are innately prone to silicosis and related diseases
7. A plan to promote sustainable US scientific discovery and innovation in the 21st century is proposed in OMICS
8. Discovery opens door to therapeutic development for FSH muscular dystrophy
9. Possible discovery of earliest animal life pushes back fossil record
10. Discovery of possible earliest animal life pushes back fossil record
11. Huntingtons disease discovery provides new hope for treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... MOUNTAIN VIEW, Calif. , Dec. 4, 2014 ... and safety has boosted investments in new testing ... products has also given rise to a range ... driven by the requirements of Generation Y, which ... digital technologies. As a result, product development strategies ...
(Date:12/3/2014)... -- As part of our commitment to offering the ... announce the release of a new reader that will ... data that they need. The Atlas 2000 ... readers. Many such devices have serious shortcomings when it ... models force users to navigate numerous complicated steps in ...
(Date:11/21/2014)... Wash. , Nov. 20, 2014 C-Labs ... for the Internet of Things (IoT), today announced the ... of chief operating officer. Previously a strategic advisor to ... finance, and operations. Mr. Traynor is based out of ... . He reports to Chris Muench , Chief ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Inception Technologies to Release New Biometric Reader 2C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... play a bigger role than food alone, when it comes ... evidence over the past 150 years found that the effects ... override the effects of food alone on tooth decay. The ... Obesity Reviews . Professor Monty Duggal, an author ...
... Space Biomedical Research Institute (NSBRI) has selected Daniela ... one of four young investigators in the nation ... is a postdoctoral fellow in Georgetown,s Lombardi Comprehensive ... and Molecular & Cellular Biology. In the ...
... Sawyer will use a $120,000 grant from the Foundation for ... the cells it attacks have evolved together over time. The ... drugs. When HIV infiltrates cells, the virus hijacks its ... It has been recently found that the retrovirus hijacks about ...
Cached Biology News:GUMC young scientist selected postdoc Fellow at National Space Biomedical Research Institute 2Evolutionary biologist will study HIV with grant from AIDS research foundation 2
(Date:12/24/2014)... December 23, 2014 Pipette.com announces their ... Twitter followers can submit their #HolidayInTheLab pictures for a ... lab mates. , For those struggling to think of ... Pipette.com Holiday in the Lab Contest provides the ideal ... followers to send pictures of their chemistree, holiday ...
(Date:12/24/2014)... , December 23, 2014 ... Algeria , out today and available for free download ... actors driving change and growth in the sector today. ... scored notable successes has been in developing a homegrown pharmaceutical ... percent local production still remains some way off. A cursory ...
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014 ... pilot study of mazindol in children with attention deficit/hyperactivity ... in December 2014 . The paper, ... with attention deficit/hyperactivity disorder" ( Konofal et al, ... 1;8:2321-2332. eCollection 2014 ) shows that mazindol might ...
(Date:12/22/2014)... , Dec. 22, 2014 /PRNewswire/ - RepliCel Life Sciences ... medicine company focused on the development of autologous cell ... of the University of Calgary in conjunction with co-authors ... which further validates the company,s ongoing clinical research using ... of pattern baldness. The paper entitled " ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5
... LEXINGTON, Mass., June 24 Instrumentation Laboratory,(IL) today ... Premier 4000,critical care analyzer. The recipient for this ... IL began shipping the new GEM Premier 4000,analyzers ... The remarkable,commercial success of this breakthrough analyzer underlines ...
... IRVINE, Calif., June 24 Stason Pharmaceuticals, ... announced,today that it has appointed Diana Wood ... be responsible for all business development,functions, including ... is a senior executive with extensive experience ...
... British Columbia researchers has developed a technique that controls ... superconductors, a procedure considered impossible for the past two ... the team deposited potassium atoms onto the surface of ... the scientists to continuously manipulate the number of electrons ...
Cached Biology Technology:Instrumentation Laboratory Ships 1000th GEM Premier 4000 Analyzer to Scripps Health 2Instrumentation Laboratory Ships 1000th GEM Premier 4000 Analyzer to Scripps Health 3Stason Pharmaceuticals, Inc. Appoints Diana Wood as Vice President, Business Development 2UBC physicists develop 'impossible' technique to study and develop superconductors 2
... useful for routine procedures. Hollandes contains formaldehyde ... will decalcify small bone specimens. Tissue that ... successfully with most stains, and the cupric ... cell membranes and cosinophil and endocrine cell ...
... CHEMICON's In Vitro Osteogenesis Assay Kit ... MC3T3-E1cells to a mature osteoblastic lineage, as ... this kit provides all the necessary reagents ... a standard plate reader. This product is ...
... gold standard for automated bioresearch: Developed ... applications • Based on decades of ... accessories designed for bioresearch • Holographic ... Versatility, reliability and ease-of-use • Pulsed ...
... Using information-rich MSn data, the patent-pending ... multiple levels of fragmentation, isotope pattern ... to accurately determine the correct formula ... approaches for deducing empirical formulae from ...
Biology Products: