Navigation Links
Discovery of key pathway interaction may lead to therapies that aid brain growth and repair
Date:9/16/2010

WASHINGTON, DCResearchers at the Center for Neuroscience Research at Children's National Medical Center have discovered that the two major types of signaling pathways activated during brain cell developmentthe epidermal growth factor receptor pathway and the Notch pathwayoperate together to determine how many and which types of brain cells are created during growth and repair in developing and adult brains. This knowledge may help scientists design new ways to induce the brain to repair itself when these signals are interrupted, and indicate a need for further research to determine whether disruptions of these pathways in early brain development could lead to common neurodevelopmental disorders such as epilepsy, cerebral palsy, autism, Down syndrome, ADHD, and intellectual disabilities.

"By understanding how these cellular signaling pathways operate in the brain, we may be able to develop genetic or molecular approaches that target those signals to facilitate or induce regeneration of the brain from neural stem cells," said Vittorio Gallo, PhD, director of the Center for Neuroscience Research at Children's National. "These signaling pathways, normally activated during brain development, work in concert through the cellular microenvironment and through interactions with existing brain cells to determine how many of each type of brain cell are required for proper brain function."

These findings will be published in the September issue of Nature.

Dr. Gallo and the research team used an approach in a laboratory setting that modified genes involved in the two signaling pathways. This approach induced gain or loss of function, allowing researchers to change the properties of neural stem cells as they developedincluding altering the size of the pool of
'/>"/>

Contact: Jennifer Stinebiser
jstinebi@cnmc.org
202-476-4500
Children's National Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biofuel from inedible plant material easier to produce following enzyme discovery
2. Discovery offers hope of saving sub-Saharan crops from devastating parasites
3. Gene discovery holds key to growing crops in cold climates
4. First discovery of bilirubin in a flower announced
5. Report: Discovery networks hostage-taking a rare terror event
6. New discovery suggests our lungs are innately prone to silicosis and related diseases
7. A plan to promote sustainable US scientific discovery and innovation in the 21st century is proposed in OMICS
8. Discovery opens door to therapeutic development for FSH muscular dystrophy
9. Possible discovery of earliest animal life pushes back fossil record
10. Discovery of possible earliest animal life pushes back fossil record
11. Huntingtons disease discovery provides new hope for treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... University (ANU), have developed a new way to ... the past 5.3 million years., The findings will ... ages over the past two million years, and ... levels, global temperatures and sea levels., The team ... the National Oceanography Centre (NOC) in the United ...
(Date:4/16/2014)... species of yellow-shouldered bats have been unearthed by scientists at the ... History and described in the open access journal ZooKeys ... are part of a recent discovery of three bats hidden ... to be officially announced. , Up until recently the genus ...
(Date:4/16/2014)... Doucet of the Centre INRSInstitut Armand-Frappier has just received a ... the amount of nearly US$600,000. The 5-year grant is to ... RNases and to explore their biomedical potential in the field ... , "Receiving a grant at this level is an ...
Breaking Biology News(10 mins):Ancient sea-levels give new clues on ice ages 2Two new species of yellow-shouldered bats endemic to the Neotropics 2High-level NIH grant goes to professor Nicolas Doucet of INRS 2
... Embryonic stem cells, prized for their astonishing ability to apparently ... their identities in part by interacting with their surroundings - ... laboratory dish, University of Florida scientists report. , Using an ... McKnight Brain Institute have begun to answer one of the ...
... fact, beneficial microbes could represent the future of medicine, ... in humans and animals from diarrhea and eczema to ... released by the American Academy of Microbiology, Probiotic Microbes: ... used to treat a range of clinical conditions that ...
... have discovered a new gene that could lead to ... diabetes. , The gene, called SLIRP, was discovered by ... Research's (WAIMR) Laboratory for Cancer Medicine, led by Professor ... at Baylor College of Medicine in Texas. , "When ...
Cached Biology News:Birds going extinct faster due to human activities 2Birds going extinct faster due to human activities 3Report focuses on the role good microbes play in future medicine 2Gene discovery opens door to tackling disease 2
(Date:1/15/2014)... January 15, 2014 Two champions of ... their sponsorship of an annual competition for middle and ... access to, innovative STEM study. The competition presents students ... Tests of Engineering Aptitude, Mathematics, and Sciences is ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched Sound ... Patients listen to sound therapy that is tailor-made for ... to months, their tinnitus volume decreases. , AudioNotch has previously ... Notched White Noise. Now, AudioNotch is pleased to announce to ...
(Date:1/14/2014)... Communications, a leading provider of strategic communications services to corporations and ... the United States and Europe ... JD, is returning to the firm,s Washington, D.C. ... more than two years of service as Associate Commissioner for the ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management software, today ... In this role, Michelle will work with current and potential ... development of iLab products. Her main goal will be to ... scientific community by offering the most advanced, user-friendly, and high-impact ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... (Frankfurt Stock Exchange: EVT) today announced that Jörn,Aldag, President & CEO, ... Date: Tuesday, ... 11.45 am EST (05.45 pm CET/04.45 pm GMT) Location: ... will be available on the Evotec website at, http://www.evotec.com - ...
... . , ANN ARBOR, Mich.---A new energy-capturing knee ... a portable GPS locator, a cell phone, a motorized ... University of Michigan shows. , A report on the ... the journal Science. Authors include researchers from Simon Fraser ...
... BRISBANE, Calif., Feb. 7 InterMune, Inc.,(Nasdaq: ITMN ) ... ended December 31, 2007. The company also provided 2008,financial guidance ... the Fourth Quarter 2007, InterMune reported a net loss ... per share, compared with a net loss of $21.5 million, ...
Cached Biology Technology:Knee brace generates electricity from walking 2InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 2InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 3InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 4InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 5InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 6InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 7InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 8InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 9InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 10InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 11
... protein ribonuclease inhibitor that noncovalently binds and inactivates ... seen with RNase 1, T1, T2, H, U1, ... placental ribonuclease inhibitor in that it has a ... release active RNase in the absence of DTT ...
... (Chemical Inkjet Printer) is a revolutionary ... and Protein Macroarray Analysis, developed in ... The strategy compliments established protocols in ... the proteins isoelectric point and apparent ...
... The BIOLASE Core Kit ... to perform polymerase assays on ... templates. In addition to dNTPs, ... on our widely used BIOLASE ...
Canine Aortic Smooth Muscle Cells (CnAOSMC) (>500,000 cells)...
Biology Products: